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排序方式: 共有975条查询结果,搜索用时 0 毫秒
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E S Komarinski? A S Shevchenko B V Romaniv V S Redzi? 《Klinichna khirurhiia / Ministerstvo okhorony zdorov'ia Ukra?ny, Naukove tovarystvo khirurhiv Ukra?ny》1990,(9):21-22
The authors treated 462 patients with acute cholecystitis. Operated on were 220 patients. Of them, 53.6%--at the first 24 hours after admission. In 26.3% of the patients, peritonitis was an indication for the operation. The postoperative lethality was 4.1%. 相似文献
3.
A A Grosu N M Shevchenko S I Zhosan S E Tsurkan A N Testemitsanu 《Terapevticheski? arkhiv》1989,61(4):75-78
A study was made of the clinical importance of atrial fibrillation-flutter (AFF) induced by using different modes of left atrium stimulation via the esophagus. Ninety-eight patients were entered into the study including 40 patients with a history of AFF paroxysms, 24 with risk factors of AFF development, and 27 practically normal persons. The stimulation modes applied permitted reproducing stable paroxysms of AFF in 85 percent of the patients with a history of arrhythmias and in none of the normal persons. As for the patients with risk factors, stable paroxysms of AFF could be induced in 33 percent of the cases. The specificity and sensitivity of transesophageal electrophysiologic stimulation (TEES) with the modes applied were 100 and 82 percent, respectively. The investigations have demonstrated that TEES appeared most effective when applied in the mode of an even increase of the frequency of the set pace up to 300 imp/min. 相似文献
4.
Borisova NP Kostyuk GV Shevchenko NA Boikov PY Rudakova EV Papina RI Terent'ev AA 《Bulletin of experimental biology and medicine》2003,135(3):253-257
Experiments on resting hepatocytes with inactive c-fos gene and active albumin gene. We revealed that DNA of the transcribed gene is less susceptible to the influence of endogenous Ca2+/Mg(2+)-dependent DNases in matrix-associated and highly soluble chromatin fractions. In the fraction of low soluble chromatin active gene was more accessible for DNases. Our results indicate that activity of endogenous DNases can change in the transcribed gene locus. 相似文献
5.
A. N. Smirnov E. V. Pokrovskaya V. P. Shevchenko I. S. Levina A. V. Kamernitskii 《Bulletin of experimental biology and medicine》1998,125(5):471-473
Binding of3H-16α, 17α-cyclopropanoprogesterone (CPG) and3H-progesterone (PG) to progesterone receptors in soluble fraction of rat uterus is studied. It is shown that CPG and PG specifically
bind to the protein with similar affinity and binding capacity. Unlabeled PG competitively inhibits the binding of CPG, and
unlabeled CPG competitively inhibits the binding of PF with the same efficiency. Dissociation of CPG- and PG-receptor complexes
is characterized by the same dissociation constant.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 5, pp. 532–534, May, 1998 相似文献
6.
Anticoagulant Activity of Fucoidan from Brown Algae Fucus evanescens of the Okhotsk Sea 总被引:2,自引:0,他引:2
Kuznetsova TA Besednova NN Mamaev AN Momot AP Shevchenko NM Zvyagintseva TN 《Bulletin of experimental biology and medicine》2003,136(5):471-473
In vitro and in vivo experiments showed that anticoagulant activity of sulfated polysaccharide from Fucus evanescens (brown algae of the Okhotsk Sea) was similar to that of heparin. Anticoagulant properties of fucoidan are determined by thrombin inhibition mediated via plasma antithrombin III. 相似文献
7.
B I Simenach Iu G Polozov E Ia Pankov S D Shevchenko 《Ortopediia travmatologiia i protezirovanie》1990,(3):1-8
The authors consider the problem of pathology of the hip joint from the point of view of the conception "Dysplasia-coxarthrosis". A single system of the ideas concerning dysplastis pathology is presented, which will allow to unify the methods of diagnosis and treatment of dysplasia of the hip joint in children, adolescents and adults with the aim of prevention of crippling diseases of the joint. 相似文献
8.
9.
Zubkov VI Silant'ev VV Deev VA Shevchenko VM Lomonosov SP 《Klinichna khirurhiia / Ministerstvo okhorony zdorov'ia Ukra?ny, Naukove tovarystvo khirurhiv Ukra?ny》2000,(12):43-44
In 22 patients with purulent-septic complications the extracorporal attaching of the xenolien cryopreserved sections was applied together with conventional therapy. Distinct reduction of the endogenic intoxication severity an the immune state of patients normalization were noted. 相似文献
10.
Comparison of d-g3139 and its enantiomer L-g3139 in melanoma cells demonstrates minimal in vitro but dramatic in vivo chiral dependency. 总被引:1,自引:0,他引:1
Johnathan C Lai Bob D Brown Anatoliy M Voskresenskiy Stefan Vonhoff Sven Klussman Wenzhi Tan Marco Colombini Risini Weeratna Paul Miller Luba Benimetskaya Cy A Stein 《Molecular therapy》2007,15(2):270-278
G3139 (Genasense), an 18mer phosphorothioate antisense oligonucleotide targeted to the initiation codon region of the Bcl-2 messenger RNA (mRNA), downregulates Bcl-2 protein and mRNA expression in many cell lines. However, both the in vitro and in vivo mechanisms of action of G3139 are still uncertain. The isosequential L-deoxyribose enantiomer L-G3139, which does not downregulate Bcl-2 expression, was synthesized to study the role of the Bcl-2 protein in melanoma cells. Both D-G3139 and L-G3139 bind nonspecifically to basic fibroblast growth factor with approximately the same K(c), and cause highly effective inhibition of net formation in 518A2 melanoma cells on Matrigel. The uptakes of D-G3139 and L-G3139 in melanoma cells were also similar. However, unlike D-G3139, L-G3139 does not produce poly ADP-ribose polymerase-1 and procaspase-3 cleavage at 9.5 h after the initiation of the transfection, but can activate the intrinsic pathway of apoptosis at approximately 48 h. Furthermore, treatment of A375 melanoma human xenografts in severe combined immunodeficiency (SCID) mice demonstrates that tumor growth is not inhibited by L-G3139, whereas D-G3139 significantly inhibits the rate of tumor growth. Furthermore, the immunostimulatory properties of L-G3139 appear to be nil, which differs dramatically from those of D-G3139. In conclusion, profound differences exist between D-G3139 and L-G3139 in vivo despite their similarities in vitro. 相似文献