全文获取类型
收费全文 | 34468篇 |
免费 | 3603篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 206篇 |
儿科学 | 1097篇 |
妇产科学 | 964篇 |
基础医学 | 4865篇 |
口腔科学 | 698篇 |
临床医学 | 4138篇 |
内科学 | 6193篇 |
皮肤病学 | 543篇 |
神经病学 | 3024篇 |
特种医学 | 1407篇 |
外国民族医学 | 3篇 |
外科学 | 4404篇 |
综合类 | 757篇 |
一般理论 | 43篇 |
预防医学 | 4240篇 |
眼科学 | 881篇 |
药学 | 2582篇 |
中国医学 | 45篇 |
肿瘤学 | 2004篇 |
出版年
2022年 | 269篇 |
2021年 | 612篇 |
2020年 | 327篇 |
2019年 | 572篇 |
2018年 | 600篇 |
2017年 | 464篇 |
2016年 | 511篇 |
2015年 | 543篇 |
2014年 | 759篇 |
2013年 | 1133篇 |
2012年 | 1628篇 |
2011年 | 1595篇 |
2010年 | 933篇 |
2009年 | 835篇 |
2008年 | 1447篇 |
2007年 | 1531篇 |
2006年 | 1528篇 |
2005年 | 1463篇 |
2004年 | 1430篇 |
2003年 | 1339篇 |
2002年 | 1271篇 |
2001年 | 1186篇 |
2000年 | 1202篇 |
1999年 | 1027篇 |
1998年 | 418篇 |
1997年 | 375篇 |
1996年 | 353篇 |
1995年 | 297篇 |
1994年 | 328篇 |
1993年 | 320篇 |
1992年 | 813篇 |
1991年 | 780篇 |
1990年 | 767篇 |
1989年 | 666篇 |
1988年 | 689篇 |
1987年 | 646篇 |
1986年 | 595篇 |
1985年 | 657篇 |
1984年 | 534篇 |
1983年 | 417篇 |
1982年 | 264篇 |
1981年 | 280篇 |
1979年 | 462篇 |
1978年 | 343篇 |
1977年 | 256篇 |
1976年 | 270篇 |
1975年 | 253篇 |
1974年 | 285篇 |
1973年 | 261篇 |
1972年 | 268篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
2.
3.
4.
5.
Jenny U. Johansson Nathaniel S. Woodling Qian Wang Maharshi Panchal Xibin Liang Angel Trueba-Saiz Holden D. Brown Siddhita D. Mhatre Taylor Loui Katrin I. Andreasson 《The Journal of clinical investigation》2015,125(1):350-364
Microglia, the innate immune cells of the CNS, perform critical inflammatory and noninflammatory functions that maintain normal neural function. For example, microglia clear misfolded proteins, elaborate trophic factors, and regulate and terminate toxic inflammation. In Alzheimer’s disease (AD), however, beneficial microglial functions become impaired, accelerating synaptic and neuronal loss. Better understanding of the molecular mechanisms that contribute to microglial dysfunction is an important objective for identifying potential strategies to delay progression to AD. The inflammatory cyclooxygenase/prostaglandin E2 (COX/PGE2) pathway has been implicated in preclinical AD development, both in human epidemiology studies and in transgenic rodent models of AD. Here, we evaluated murine models that recapitulate microglial responses to Aβ peptides and determined that microglia-specific deletion of the gene encoding the PGE2 receptor EP2 restores microglial chemotaxis and Aβ clearance, suppresses toxic inflammation, increases cytoprotective insulin-like growth factor 1 (IGF1) signaling, and prevents synaptic injury and memory deficits. Our findings indicate that EP2 signaling suppresses beneficial microglia functions that falter during AD development and suggest that inhibition of the COX/PGE2/EP2 immune pathway has potential as a strategy to restore healthy microglial function and prevent progression to AD. 相似文献
6.
7.
José A. Lorente Pablo Cardinal-Fernández Diego Muñoz Fernando Frutos-Vivar Arnaud W. Thille Carlos Jaramillo Aida Ballén-Barragán José M. Rodríguez Oscar Peñuelas Guillermo Ortiz José Blanco Bruno Valle Pinheiro Nicolás Nin María del Carmen Marin Andrés Esteban Taylor B. Thompson 《Intensive care medicine》2015,41(11):1921-1930
8.
Jerome Marley Julia Taylor Jane Brocksom Kath Schubach Andrea Nixon Paula Allchorne Susanne Vahr Lauridsen 《International Journal of Urological Nursing》2020,14(1):5-12
A series of three World Café events centred on the topic of developing an Educational Framework for Urological Nursing [EFUN] were held by the British Association of Urological Nurses [BAUN], the European Association of Urology Nurses [EAUN] and the Australian and New Zealand Urological Nursing Society [ANZUNS] between 2017 and 2019. About 376 urology nurses participated in these “conversations that matter” and generated 1047 individual response items that were grouped into themes to assist the three associations to take the creation of an EFUN to the next level. Areas explored centred on four aspects: what any agreed educational framework for urology nursing should contain; the academic level at which education should be provided; who should be recruited as collaborators on writing an educational framework and, lastly, just how any emergent framework should be used. Analysis of the conversational data indicate that there exists within the urological nursing community a collective wisdom regarding their educational needs and how these needs should be met. 相似文献
9.
10.
La Creis R Kidd K Woodson P R Taylor D Albanes J Virtamo J A Tangrea 《European journal of cancer prevention》2003,12(4):317-320
Glutathione-S-transferase (GST) genes encode a family of detoxification enzymes that offer protection against endogenous and exogenous sources of reactive oxygen species (ROS). Germline variations in GST genes may alter the catalytic efficiency of GST isoenzymes leading to a potential increase in susceptibility to the genotoxic effects of ROS and electrophilic substances. A nested case-control study design was used to examine the association between the polymorphic GST genes and prostate cancer risk among Finnish male smokers of the ATBC Cancer Prevention Study. A case-case analysis was used to determine the association between these genetic polymorphisms and prostate cancer progression. Germline DNA was obtained from 206 prostate cancer cases and 194 controls frequency matched on age, intervention group and study clinic. Cases and controls were genotyped for three GST genes using MALDI-TOF mass spectrometry or multiplex polymerase chain reaction (PCR). Relative to the wild-type genotype, we observed a 36% reduction in prostate cancer risk associated with the GST-M1-null genotype (odds ratio (OR) 0.64, 95% confidence interval (CI) 0.43, 0.95). Unlike GST-M1, GST-T1-null (OR 0.74, 95% CI 0.42, 1.33) and GST-P1*B (OR 1.10, 95% CI 0.72, 1.69) were not strongly associated with prostate cancer risk. We did not observe any significant associations between the selected polymorphic GST genes and tumour grade or stage. In conclusion, we did not observe a direct association between polymorphic GST-T1 or GST-P1 and prostate cancer risk. Our observation of a relatively strong inverse association between the GST-M1-null genotype and prostate cancer risk needs to be confirmed in larger association studies. 相似文献