Effects of antibiotics on reactive oxygen species generation by neutrophils

Antibiotic therapy of patients with exacerbation of chronic obstructive bronchitis exposed and not exposed to ozone did not improve oxidative metabolism in neutrophils. Cefazolin, ceftizoxime, and gentamicin normalized functional biocidal reserves of neutrophils, which correlated with pronounced therapeutic effects.     

The establishment of the maximum permissible concentration of the new plant growth stimulant T-86 in the air of a work area

LD50 of plant growth stimulator T-86 was determined at the levels: 7500 mg/kg for rats, 1475 mg/kg for white mice, and 5000 mg/kg for rabbits. Moderate skin resorptive effect of the agent was revealed. Limac of T-86 is 290 mg/m3, Limch 12 mg/m3, threshold embryotoxic effect 5.2 mg/m3, and MAC for work zone air 0.5 mg/m3.     

Effects of different antibiotics on free radical oxidationIn Vitro andIn Vivo

Effects of naturally occurring and semisynthetic penicillins, cephalosporines, amino-glycosides, tetracyclines, and lincomycin on free-radical oxidation were studied in 4 model systems and in intact Wistar rats. Liver and kidney tissue and blood plasma were examined by chemiluminescence. Antibiotics of all groups in therapeutic concentrations exerted antioxidant effectin vitro andin vivo. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 3, pp. 297–299, March, 1998     

Lipid Peroxidation-Antioxidant Activity System in Erythrocytes of Patients with Chronic Bronchitis Inhaling and Not Inhaling Ozone

Development of chronic bronchitis in individuals chronically exposed to ozone is associated with complex changes in the lipid peroxidation-antioxidant activity system in erythrocytes characterized by intensification of lipid peroxidation and parallel attenuation of antioxidant activity.     

Role of JNK in the Regulation of Xenobiotic Metabolizing Function of Hepatocytes

Bulletin of Experimental Biology and Medicine - We studied the role of JNK in the regulation of the metabolism of xenobiotic venlafaxine by liver cells under in vitro conditions. The inhibitory...