全文获取类型
收费全文 | 32篇 |
免费 | 2篇 |
专业分类
妇产科学 | 1篇 |
基础医学 | 6篇 |
临床医学 | 7篇 |
内科学 | 7篇 |
皮肤病学 | 2篇 |
外科学 | 4篇 |
预防医学 | 3篇 |
眼科学 | 2篇 |
药学 | 2篇 |
出版年
2017年 | 1篇 |
2015年 | 1篇 |
2014年 | 2篇 |
2013年 | 2篇 |
2011年 | 1篇 |
2010年 | 1篇 |
2009年 | 1篇 |
2007年 | 1篇 |
2006年 | 1篇 |
1999年 | 1篇 |
1998年 | 2篇 |
1996年 | 2篇 |
1995年 | 3篇 |
1994年 | 2篇 |
1993年 | 2篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1986年 | 1篇 |
1972年 | 1篇 |
1970年 | 1篇 |
1959年 | 1篇 |
1958年 | 1篇 |
1954年 | 1篇 |
排序方式: 共有34条查询结果,搜索用时 15 毫秒
1.
JEFFREY R. FRY JULIA H. FENTEM ALENA SALIM S. P. ANNA TANG MICHAEL J. GARLE DONALD A. WHITING 《The Journal of pharmacy and pharmacology》1993,45(3):166-170
Abstract— The interaction of glutathione (GSH) with coumarin, or one of a series of compounds related to coumarin, was assessed in the absence and presence of liver microsomes (direct reaction and indirect reaction, respectively) to determine the structural requirements for direct and mono-oxygenase-mediated reaction of cyclic α,β-unsaturated carbonyls with GSH. Acrolein was used as a positive control for the direct reaction, and produced complete or nearly complete depletion of GSH under all assay conditions. 5,6-Dihydro-2H-pyran-2-one and 2-cyclohexen-1-one also produced substantial depletion of GSH in the direct reaction, which was not increased by the addition of liver microsomes. Coumarin, 2H-pyran-2-one and precocene I (a substituted pyran lacking the 2-one structure) were not substrates for the direct reaction but did cause depletion of GSH when incubated in the presence of rat or human liver microsomes. These depletions were dependent on a functioning mono-oxygenase system as judged by the effects of omission of cofactors, addition of competitive or inactivating inhibitors of cytochrome P450, and induction. Dihydrocoumarin, ?-valerolactone, cyclohexanone and 4H-pyran-4-one were not substrates for either the direct or indirect reaction. These findings are rationalized on the basis of a direct nucleophilic attack of GSH on the α,β-centre of the α,β-unsaturated carbonyl compounds, which is hindered by benzenoid resonance in coumarin and 2H-pyran-2-one, for which enzyme-mediated reaction with GSH, probably via a 3,4-epoxide, is the favoured mechanism. 相似文献
2.
RICHARD G. LEA JENNY UNDERWOOD KATHY C. FLANDERS HAL HIRTE DALJEET BANWATT SUZETTA FINOTTO ISAO OHNO SALIM DAYA CALVIN HARLEY MAGDY MICHEL JAMES F. MOWBRAY DAVID A. CLARK 《American journal of reproductive immunology (New York, N.Y. : 1989)》1995,34(1):52-64
PROBLEM : To determine if patients with unexplained recurrent miscarriage have a deficiency of decidual immunosuppressor cells that produce transforming growth factor β type 2, as has been found in mice with abortion due to rejection and/or trophoblast failure. METHODS : Decidual biopsy specimens were taken as near to the placental attachment site as possible under ultrasound guidance from first trimester legal termination (control) patients with recurrent miscarriage and non-viable pregnancy, and from patients with sporadic missed abortion. The tissue was tested for TGFβ-2+ suppressor cells by in situ hybridization, immunohistochemistry, and analysis of supernatants. RESULTS : TGFβ-2-related suppressor molecules similar but not identical to those identified in pregnant mice were released by decidual lymphoid cells. Fifty percent of 14 recurrent miscarriage patients showed a lack of suppressor cells and 59% were subnormal in comparison to 20 controls and 5 sporadic miscarriage patients, where 80–85% of the patients had detectable suppressor cells. CONCLUSIONS : Suppressor cell deficiency is compatible with a role for rejection and/or trophoblast failure in some patients with recurrent miscarriage. Presence of suppressor cells in most patients with missed abortion (4/5) is compatible with an alternative cause of fetal death, similar to findings reported in genetic fetal death mice. 相似文献
3.
SALIM DAYA DAVID A. CLARK 《American journal of reproductive immunology (New York, N.Y. : 1989)》1986,11(3):98-101
ABSTRACT: Embryonic loss prior to implantation appears to be a significantly frequent phenomenon and this is further reinforced by the very low pregnancy rates reported by in vitro fertilization and embryo transfer programs. Implantation failure may possibly be the result of rejection of the antigenic embryo by the hostile maternal immune system. The mechanism by which embryos in successful pregnancies escape these rejection responses may depend upon their ability to produce factor(s) that suppress in vitro mitogen-induced lymphocyte proliferation. Only 43% of cleaved embryos demonstrated this ability. We postulate that successful pregnancies are dependent upon the production by embryos of immunosuppressor factor(s) that has a direct suppressive effect on the maternal immune response. 相似文献
4.
5.
Twenty-two neuroendocrine tumours of the larynx were investigated using a panel of immunocytochemical markers. Three were small cell carcinomas, eight were large cell neuroendocrine carcinomas and 11 were paragangliomas. Twenty were positive for protein gene product 9.5, 19 for neuron-specific enolase, 15 for chromogranin A, nine for bombesin, eight for substance P, eight for neuropeptide Y, eight for metenkephalin, seven for somatostatin, five for calcitonin, eight for calcitonin gene-related peptide and one for vasoactive intestinal polypeptide. Bombesin immunoreactivity was largely restricted to the small cell carcinomas and large cell neuroendocrine carcinomas and neuropeptide Y, metenkephalin and substance P to the parangangliomas. This comprehensive immunocytochemical analysis of neuroendocrine tumours of the larynx demonstrates that these tumours represent special entities but have similar patterns of immunostaining to those of neuroendocrine tumours in other sites. 相似文献
6.
7.
8.
THOMAS G. DI SESSA M.D. MUBADDA A. SALIM M.D. BRUCE S. ALPERT M.D. 《Echocardiography (Mount Kisco, N.Y.)》1998,15(8):761-768
In infants and children, right heart failure is most frequently a consequence of increased afterload (pulmonary hypertension). However, it is also observed as a sequela of congenital cardiovascular surgery. The purpose of this report is to present the causes of right heart dysfunction in children and to define the echo-Doppler methods used in the evaluation of right heart failure. 相似文献
9.
The distribution of glycoconjugates was examined in the nonsensory regions of the rat cochlea during postnatal development using biotin-conjugated lectins. Temporal bones of rats at postnatal d 1 and at wk 2, 4 and 6 were fixed in 4% paraformaldehyde and 0.1% glutaraldehyde and processed for paraffin wax embedding. The dewaxed sections were incubated with 7 biotinylated lectins, followed by avidin-biotin-peroxidase complex. A different staining pattern was observed in the stria vascularis, spiral ligament and spiral limbus in the age groups examined. The staining intensity varied between lectins and the reaction product exhibited limited disparity. The staining intensity for WGA increased with age in all the 3 nonsensory regions. The staining patterns for the other lectins differed in the various nonsensory regions examined indicating tissue specificity. The limited variations in the lectin binding patterns after 2nd wk of postnatal life also indicate that the changes in the carbohydrate moieties are established during the fetal period of cochlear development and limited changes take place during postnatal maturation of the nonsensory regions. 相似文献
10.
MOHAMMED SALIM AL‐DAMLUJI M.D. M.P.H. SAMEER NAGPAL M.D. ERIK STILP M.D. MICHAEL REMETZ M.D. CARLOS MENA M.D. F.A.C.C. 《Journal of interventional cardiology》2013,26(4):399-410