RELIEVING EFFECTS OF CHINESE HERBS,EAR-ACUPUNCTURE AND EPIDURAL MORPHING ON POSTOPERATIVE PAIN IN LIVER CANCER

In the evaluation of Chinese berbs(A),ear-acupuncture(B) and epidural morphine(C) to relieve postoperative pain and abdominal distension,sixteen male patients with primary liver cancer were observed.This study was conducted by means of orthogonal experiment and double blind,randomized design.     

二氢埃托啡耐受后小鼠脑内cAMP含量的减少及氨基酸含量的增加

目的：探讨二氢埃托啡（ＤＨＥ）耐受的机制．方法：放免法及反相高效液相色谱荧光检测法测定环腺苷一磷酸（ｃＡＭＰ）及谷氨酸（Ｇｌｕ）、门冬氨酸（Ａｓｐ）、谷氨酰氨（Ｇｌｎ）、ＧＡＢＡ的含量．结果：ＤＨＥ反复ｓｃ８ｄ后产生耐受．小鼠去小脑全脑Ｇｌｕ、Ａｓｐ、ＧＡＢＡ的基础含量分别由对照组的１４１±２１、３０±０４、１８±０８升高至耐受组的１７２±２２、４１±０６、３２±１０μｍｏｌ／ｇ组织，Ｇｌｎ的含量无明显改变．下丘脑及纹状体的ｃＡＭＰ基础含量分别由对照组的２７１±３８、１８９±３１降至耐受组的９６±１５、６５±２１ｎｍｏｌ／ｇ组织，大脑皮层ｃＡＭＰ的含量无明显改变．结论：ＤＨＥ耐受与脑内Ｇｌｕ、Ａｓｐ、ＧＡＢＡ基础含量的升高及下丘脑、纹状体内ｃＡＭＰ的基础含量的降低有关．     

中药葛根、吴茱萸对双氢埃托啡耐受小鼠的影响

目的：探讨中药对延缓ＤＨＥ耐受小鼠脑内的下丘脑以及杏仁核ＣＣＫｍ ＲＮＡ 表达的影响。方法：采用热板法,以添足底反应潜伏期为痛阈。Ｑ５００ＩＷ 软包分析小鼠脑内ＣＣＫｍ ＲＮＡ 表达量。结果：小鼠接受混合中药后,从第３ｄ 开始到第７ｄ 为止,ＡＵＣ值一直保持较高的水平。第７ｄ ＡＵＣ值与单纯ＤＨＥ组比较,前者为（４４５８．４±１３５７．６）,而后者（１７７３．６±１１４４．２）,两者存在差异有显著意义（Ｐ＜ ０．０５）。ＣＣＫｍ ＲＮＡ 原位杂交信号经图像处理结果：下丘脑和杏仁核ＣＣＫｍ ＲＮＡ 表达,耐受组分别为１０３．９２和１８１．１９,明显高于混合中药组和对照组（４５．７２和７０．１３）Ｐ＜ ０．０５,而中药组为５１．０３和９２．２９与对照组相比无明显差异Ｐ＞ ０．０５。结论：ＤＨＥ耐受小鼠,脑内下丘脑和杏仁核ＣＣＫｍ ＲＮＡ 表达的增加,可能是产生ＤＨＥ耐受的原因之一。     

A PRELIMINARY STUDY ON THE MECHANISM OF EAR-ACUPUNCTURE FOR WITHDRAWAL OF SMOKING

The changes of smoking taste and short termeffectiveness for stopping smoking by usingcar-acupuncture in 28 heavy smokers wereobserved.Matched comparative study was per-formed between 16 heavy smokers and 16non-smokers.Four primary sensations of taste,pain tolerance threshold,plasma cortisol and plasmaleucine-enkephalin(PLEK)were measured beforeand after smoking and measured again after smokingsubsequent to ear-acupuncture.Double blind andrandomized tests between two sets of ear-acupointsand ear non-acupoints were employed in this study.The results showed:(1)The threshold for tastes tosour and sweet of smokers have become more sensi-tive after ear-acupuncture.(2)The increased PLEKlike substance(PLELS)induced by smoking couldbe inhibited by ear-acupuncture.(3).The change ofprimary sensations of taste to smoking was correlatedto the change of PLELS.(4)No obvious differencesbetween ear-acupoints and ear non-acupoints foreither parameters mentioned above or short termtherapeutic effect were found.It is suggested thatthe change of primary sensations of taste after car-acupuncture seemed to be one of the reasons forwithdrawal of cigarette smoking;PLELS might playan important role in the development and sustenanceof smoking habit,ear-acupuncture could modulatePLELS accordingly,the cortical response to endogen-ous opium-like substance,and mimicked to the effec-tiveness of naloxone for reducing cigarette smoking.     

中重度癌症疼痛病人心理反应与人格特征的关系

采用艾森克人格调查表，对１２８例中重度疼痛癌症男性患者进行了人格维度测定并与简明疼痛调查表进行相关分析。     

针刺内关对冠心病患者心功能的即刻效应

近年来的流行病学调查资料表明,心血管疾病已经跃居死亡原因的首位,其中占很大比重的冠状动脉粥样硬化性心脏病(简称冠心病)更有逐年增加的趋势,而在中壮年之后表现得尤其突出。因此,积极防治冠心病是我们医务工作者急需解决课题之一。针刺治疗冠心病疗效观察报导较多,但未见用心阻抗检测心脏功能的报导。所以我们以心功能变化作为针刺效应指标,观察针刺冠心病患者内关前后心功能的变化。