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乌司他丁对普胸患者围手术期免疫功能的影响 总被引:2,自引:1,他引:2
我们通过本研究在围手术期使用乌司他丁 ,与对照组相比较 ,初步评估其对普胸手术患者围手术期免疫功能的影响。一、材料与方法1.一般资料 :我科于 2 0 0 2年 3月~6月 ,将普胸外科手术的患者随机分为乌司他丁用药组和对照组各 2 0例。其中男 2 4例、女 16例 ;年龄 2 2~ 74岁 ,平均年龄 5 3岁 ;术式有肺叶切除术 2 9例、食管癌切除术 5例、纵隔肿瘤切除术 6例。两组患者在性别、年龄、病种和术式等方面差异均无显著性 (P >0 .0 5 )。2 .用药方法 :用药组于手术当天、术后第 1天和第 2天 ,连续 3d采用静脉滴注乌司他丁。方法为 5 %葡萄糖液 … 相似文献
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Objective To study effectiveness and safety of lung volume reduction surgery(LVRS) in treatment for severe chronic emphysema(chronic obstructive pulmonary disease).Methods Clinical data of 24 patients of severe chronic emphysema undergone with LVRS during January 2004 to June 2007 were analyzed retrospectively.LVRS was performed for the patients after respiratory tract preparation based on their pulmonary function,results of blood gas analysis,cardiac function,as well as physical activity capacity.and surgical incision Was selected based on"target"location of emphysema with chest computerized tomography and isotope lung perfusion scanning,22 cases with standard unilateral LVRS via outer post-lateral incision and two with bilateral LVRS via mid-sternal incison.A linear device for cutting and stitching was used in surgical operation to excise the lung tissues of severe emphysema with strips of bovine pericardium to prevent air leakage.Results All the patients were followed-up for 19 months in average and complications occurred in seven of them after operation,including four with leakage of the alveoli.two with cardiac arrhythmia and one with pneumonia,and no death was observed.Pulmonary function and symptoms of dyspnea improved obviously in all the patients after operation,and they all could care for themselves,in general,with scales of dyspnea increased to grade Ⅰ in one case,to grade Ⅱ in 10 cases and to grade Ⅲ in three cases.Conclusions LVRS can improve pulmonary function of selected patients with severe emphysema,to certain extent,and its safety will depend on strict selection of the patients and correct peri-operative care. 相似文献
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Objective To study effectiveness and safety of lung volume reduction surgery(LVRS) in treatment for severe chronic emphysema(chronic obstructive pulmonary disease).Methods Clinical data of 24 patients of severe chronic emphysema undergone with LVRS during January 2004 to June 2007 were analyzed retrospectively.LVRS was performed for the patients after respiratory tract preparation based on their pulmonary function,results of blood gas analysis,cardiac function,as well as physical activity capacity.and surgical incision Was selected based on"target"location of emphysema with chest computerized tomography and isotope lung perfusion scanning,22 cases with standard unilateral LVRS via outer post-lateral incision and two with bilateral LVRS via mid-sternal incison.A linear device for cutting and stitching was used in surgical operation to excise the lung tissues of severe emphysema with strips of bovine pericardium to prevent air leakage.Results All the patients were followed-up for 19 months in average and complications occurred in seven of them after operation,including four with leakage of the alveoli.two with cardiac arrhythmia and one with pneumonia,and no death was observed.Pulmonary function and symptoms of dyspnea improved obviously in all the patients after operation,and they all could care for themselves,in general,with scales of dyspnea increased to grade Ⅰ in one case,to grade Ⅱ in 10 cases and to grade Ⅲ in three cases.Conclusions LVRS can improve pulmonary function of selected patients with severe emphysema,to certain extent,and its safety will depend on strict selection of the patients and correct peri-operative care. 相似文献
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Objective To study effectiveness and safety of lung volume reduction surgery(LVRS) in treatment for severe chronic emphysema(chronic obstructive pulmonary disease).Methods Clinical data of 24 patients of severe chronic emphysema undergone with LVRS during January 2004 to June 2007 were analyzed retrospectively.LVRS was performed for the patients after respiratory tract preparation based on their pulmonary function,results of blood gas analysis,cardiac function,as well as physical activity capacity.and surgical incision Was selected based on"target"location of emphysema with chest computerized tomography and isotope lung perfusion scanning,22 cases with standard unilateral LVRS via outer post-lateral incision and two with bilateral LVRS via mid-sternal incison.A linear device for cutting and stitching was used in surgical operation to excise the lung tissues of severe emphysema with strips of bovine pericardium to prevent air leakage.Results All the patients were followed-up for 19 months in average and complications occurred in seven of them after operation,including four with leakage of the alveoli.two with cardiac arrhythmia and one with pneumonia,and no death was observed.Pulmonary function and symptoms of dyspnea improved obviously in all the patients after operation,and they all could care for themselves,in general,with scales of dyspnea increased to grade Ⅰ in one case,to grade Ⅱ in 10 cases and to grade Ⅲ in three cases.Conclusions LVRS can improve pulmonary function of selected patients with severe emphysema,to certain extent,and its safety will depend on strict selection of the patients and correct peri-operative care. 相似文献
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目的:探讨非小细胞肺癌肺内第12和13组淋巴结的转移规律及临床意义.方法:对141例行肺切除和淋巴结清扫术的非小细胞肺癌患者进行临床病理分析.结果:共取得淋巴结2154枚,平均每例15.3枚,转移率为13.1%.141例患者中55例有胸内淋巴结转移,其中N115例,N1+N2 28例,跳跃性N212例,转移率为39.0%.常规病理检测无纵膈及肺内淋巴结转移患者93例中检出单纯第12或13组淋巴结转移者7例,检出率为7.5%.T2期肺内第12和13组淋巴结转移率明显高于T1期(P<0.05),第12和13组淋巴结在低分化及中分化肺癌中的转移率分别为25.0%和8.9%(P<0.05),周围型肺癌肺内第12和13组淋巴结转移率要显著高于中央型肺癌(P<0.05).结论:非小细胞肺癌肺内第12和13组淋巴结转移与原发肿瘤大小、临床病理类型及分化程度均有密切关系.对早期非小细胞肺癌患者第12和13组淋巴结进行病理检测,可以为临床工作提供重要的指导. 相似文献
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目的:观察恶性胸腺瘤患者的手术疗效,并分析其与肿瘤分期、放疗、L/B病理分型及与预后的关系.方法:对63例恶性胸腺瘤患者进行手术治疗并辅以放疗,并按不同术式、Masaoka外科-病理分期、L/B病理分型比较,采用多因素Logistic回归分析其与预后的关系.结果:接受根治性手术,Masaoka外科-病理分期较早的患者3、5年生存率较高(P<0.05).术后加用放射性治疗与否也与3、5年生存率有关系.不同病理(L/B)类型的患者,3、5年生存率差别无统计学意义.结论:恶性胸腺瘤患者早期手术并辅以放疗可提高生存率;Masaoka外科-病理分期和预后密切相关;L/B病理分型与预后无明显相关性. 相似文献
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抗原呈递细胞(AntigenPresentingCel,APC)是能捕捉、加工处理抗原并将抗原呈递给特异性淋巴细胞的一类免疫细胞。它们包括巨噬细胞及树突状细胞(DendriticCels,DC)等,而与食管粘膜上皮关系密切的是DC。DC是一簇来源于骨... 相似文献
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目的:应用脉冲振荡肺阻力测定法(IOS)探讨间歇正压控制性机械通气(IPPV)时呼吸系统黏性阻力变化规律.方法:择期左肺肿瘤切除成年男性患者25例,根据术前肺功能测定指标分为非阻塞性肺病组(NOLD组)15例和阻塞性肺病组(OLD组)10例,所有受试者麻醉后于仰卧位和右侧卧位行双肺及右肺通气测试.应用IOS方法测定Carlen双腔气管导管5 Hz(R5)、10 Hz(R10)和15 Hz(R15)黏性阻力.结果:相同振荡频率双肺通气OLD组黏性阻力显著增加,与NOLD组比较,差异有统计学意义(P<0.05).不同潮气量和呼吸频率侧卧位单肺机械通气时NOLD组患者黏性阻力变化差异无统计学意义.当潮气量≤8 mL·kg-1、呼吸频率≥12次·min-1单肺通气时,组间R5差异有统计学意义(均P<0.05).结论:术前肺通气功能正常或仅轻度损伤的患者,围术期用Carlen双腔管做侧卧位非手术侧单肺通气,潮气量4~10 mL·kg-1,呼吸频率10~18次·min-1,不改变其呼吸动力学特性. 相似文献