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目的 探讨内外源性β-葡萄糖醛酸酶(β-G)与原发性胆总管结石的关系.方法 应用改良Fishman法检测35例原发性胆总管结石患者(试验组)和11例胆囊息肉患者(对照组)胆总管内胆汁中内外源性β-G活性.结果 试验组和对照组手术当天胆汁中内源性β-G活性分别为(7859.1±738.5)、(2174.9±348.4)U/L(P<0.01);外源性β-G活性分别为(6786.1±544.3)、(1504.7±655.7)U/L(P<0.01);试验组中13例急性患者手术当天与术后第7天胆汁中外源性β-G活性分别为(8935.7±845.9)、(2176.1±956.7)U/L(P<0.05);22例慢性患者分别为(5137.2±540.7)、(1838.8±733.3)U/L(P<0.05);急性患者手术当天胆汁中外源性β-G活性明显高于慢性患者(P<0.05).结论 内、外源性β-G参与原发性胆总管结石的形成.Abstract: Objective To explore the role of endogenous and exogenous β-glucuronidase( β-G) in the development of primary common duct stones.Method Using modified Fishman method to test the activities of the endogenous and exogenous β -G in 35 patients with primary common duct stones(experimental group) and 11 patients with cystic polypus (control group) respectively.Results The activities of endogenous β -G in the bile of experimental group and control group were (7859.1 ± 738.5 ),(2174.9 ± 348.4 ) U/L(P <0.01).While the activities of exogenous β-G in experimental group and control group were (6786.1 ±544.3),(1504.7 ±655.7) U/L (P <0.01).In experimental group,there were significant statistical differences in the activities of the exogenous β -G in the sample obtained on the day of operation and 7 days after operation from 13 cases with the acute inflammation [(8935.7 ± 845.9),(2176.1 ± 956.7) U/L]and from 22 cases with the chronic inflammation [(5137.2 ±540.7),(1838.8 ±733.3) U/L],and there were significant higher in the activities of the exogenous β -G in the sample obtained on the day of operation from the acute inflammation compared to those from the chronic inflammation (P < 0.05 ).Conclusions There is obvious correlation between either endogenous or exogenous β -G with primary common duct stones.And the endogenous β -G might be one of the fundamental cause in the development of primary common duct stones. c inflammation (P < 相似文献
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目的分析术后早期炎性肠梗阻的发病原因及探讨治疗方法。方法回顾分析该院2002年5月到2008年5月六年期间阑尾手术后发生的36例早期炎性肠梗阻病例的临床资料。结果34例患者经过保守治疗获得治愈,2例手术治疗,本组无死亡病人。结论术后早期炎性肠梗阻首选保守治疗,其中绝大多数经过保守治疗可以治愈,手术应相当慎重。 相似文献
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目的探讨经胃镜空肠置管全肠道营养(TEN)对胃癌根治性远端胃切除术后胃瘫的治疗价值。方法 57例胃癌术后胃瘫患者随机分成两组,TEN组经胃镜空肠置管行TEN支持治疗,全肠外营养(TPN)组行TPN支持治疗,评价治疗前后营养状况、免疫功能及治疗效果。结果 57例胃癌术后胃瘫患者经TEN和TPN治疗治愈,TEN组胃功能恢复时间8~23d,平均(13±4.2)d,显著短于TPN组[13~31d,平均(18±5.1)d;P<0.05]。两组支持治疗第8天后患者血清白蛋白、前白蛋白、转铁蛋白较治疗前明显提高(P<0.05),TEN组免疫学指标CD4+、CD4+/CD8+、IgA、IgG、IgM较治疗前显著改善(P<0.05),并显著高于TPN组。结论经胃镜空肠置管TEN能改善机体营养状况,增强免疫功能,促进胃功能恢复,是治疗胃癌术后胃瘫的有效手段。 相似文献
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目的探讨内外源性β-葡萄糖醛酸酶在两类原发性胆总管结石(胆固醇结石与胆色素结石)形成中的作用。方法应用Fishman法检测实验组、对照组胆总管胆汁中内、外源性β-G活性。结果胆红素结石组(PS)、胆固醇结石组(CHS)与对照组(CG)比较,内、外源性β-G活性及总活性均有显著性差异;胆红素结石组与胆固醇结石组之间比较(手术当天)外源性β-G活性差异有显著性,内源性β-G活性差异无显著性。(2)实验组手术当天胆汁中内源性β-G活性与术后第七日的比较差异无显著性;而外源性β-G活性手术前、后比较差异有显著性。结论内、外源性β-G可能是这两类原发性胆总管结石形成与再发的基本原因之一。 相似文献
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