数字钼靶X线诊断乳腺癌分析

目的探讨数字钼靶X线诊断乳腺癌的临床价值。方法于2015年6月～2018年6月选择我院35例确诊乳腺癌患者与35例确诊乳腺良性病变患者,实施数字钼靶X线检查、彩色多普勒超声检查,以临床确诊结果为参照,比较数字钼靶X线、彩色多普勒超声对乳腺癌的诊断结果,分析诊断结果间的一致性。结果以临床病理确诊结果为参照,数字钼靶X线、彩色多普勒超声对乳腺癌的诊断灵敏度、特异度、准确率比较,差异均无统计学意义(P 0.05)。数字钼靶X线、彩色多普勒超声诊断结果与临床确诊结果间的一致性良好。数字钼靶X线对规则颗粒形、不规则颗粒形、模糊粉尘形等类型钙化病灶的检出率均高于彩色多普勒超声(P 0.05),而二者对环形、蠕虫形等钙化病灶的检出率比较差异无统计学意义(P 0.05)。结论数字钼靶X线检查用于乳腺癌的诊断价值良好,尤其是对乳腺癌钙化病灶。     

胸腺瘤48例临床病理的预后相关性研究

Objective To study the relation of Clinicopathological characteristics and prognostic of thy-mic epithelial tumors. Methods To review and analyze the clinical data about 48 cases with thymic epithelial tumours were treated in surgery of our hospital,, according to the normal sort of WHO (2004 years) thymus tumor classification criteria to classify, according to the results of the clinical and follow-up and Masaoka clinical stage and prognosis, and other factors The relevance of the study. Results 48 cases of histological type of thymoma: A type for 4 cases(8.3%) ,AB type for 3(6.3%) ,B1 type for 9(18.8%) ,B2 type for 8(16.7%) ,B3 type for 11 cases(22.9% ) ,C type for 13 cases(27.1% ). Clinical staging: Ⅰ period of 12 cases(25.0% ), Ⅱ period of4 cases( 8.3% ), Ⅲ period of 13 cases(27.1% ), Ⅳ period of 19 cases(39. 6 percent). The results of follow-up data show that, Ⅰ,Ⅱ,Ⅲ,Ⅳ Thymectomy period after 3-year survival rates were 100% and 100% ,68.3%, 35.8% ;5-year survival rates were 66.5% and 66.5% ,39.7%, 18.6% and the survival rate of patients with Masaoka closely related to the clinical stage, patients with thymoma is the most important independent prognostic indicators. Conclusion Masaoka's clinical stage of survival in patients with thymoma is the most important prognostic parameters,type of tumor is complete excision is the impact on the survival of patients with thymoma an important factor.     

慢性荨麻疹患者过敏源检测分析

目的对慢性荨麻疹患者的血清进行过敏原检测，了解周边地区慢性荨麻疹患者的过敏原情况，供临床治疗作参考。方法采用酶联免疫分析法对慢性荨麻疹患者进行过敏原检测（IVT729，221例；IVT730，164例）。结果总IgE检测阳性率为91．40％。各种主要过敏原：尘螨、粉螨、屋尘占11．76％；蟑螂、飞蛾、蜜蜂占5．88％；菇类占9．15％；虾蟹类占7．32％。结论在周边地区，过敏原对荨麻疹患者的发病有着重要的影响，特别是：尘螨、粉螨、屋尘，蟑螂、飞蛾、蜜蜂、菇类及海产品类。     

阑尾黏液腺癌并阑尾脓肿形成一例

患者女，51岁，因“偶发右下腹部疼痛1个月，再发7h”于2010年9月1日入院。     

胸腺瘤48例临床病理的预后相关性研究

Objective To study the relation of Clinicopathological characteristics and prognostic of thy-mic epithelial tumors. Methods To review and analyze the clinical data about 48 cases with thymic epithelial tumours were treated in surgery of our hospital,, according to the normal sort of WHO (2004 years) thymus tumor classification criteria to classify, according to the results of the clinical and follow-up and Masaoka clinical stage and prognosis, and other factors The relevance of the study. Results 48 cases of histological type of thymoma: A type for 4 cases(8.3%) ,AB type for 3(6.3%) ,B1 type for 9(18.8%) ,B2 type for 8(16.7%) ,B3 type for 11 cases(22.9% ) ,C type for 13 cases(27.1% ). Clinical staging: Ⅰ period of 12 cases(25.0% ), Ⅱ period of4 cases( 8.3% ), Ⅲ period of 13 cases(27.1% ), Ⅳ period of 19 cases(39. 6 percent). The results of follow-up data show that, Ⅰ,Ⅱ,Ⅲ,Ⅳ Thymectomy period after 3-year survival rates were 100% and 100% ,68.3%, 35.8% ;5-year survival rates were 66.5% and 66.5% ,39.7%, 18.6% and the survival rate of patients with Masaoka closely related to the clinical stage, patients with thymoma is the most important independent prognostic indicators. Conclusion Masaoka's clinical stage of survival in patients with thymoma is the most important prognostic parameters,type of tumor is complete excision is the impact on the survival of patients with thymoma an important factor.     

盐酸多西环素肠溶胶囊联合肤痔清软膏治疗中重度寻常痤疮的疗效观察

目的：观察盐酸多西环素肠溶胶囊联合肤痔清软膏治疗中重度痤疮的疗效。方法70例中重度痤疮男性患者随机分为用盐酸多西环素肠溶胶囊联合肤痔清软膏为治疗组及单用盐酸多西环素肠溶胶囊为对照组,各35例,治疗3周及6周后统计疗效。结果治疗组及对照组总有效率于3周及6周分别为73.53%和40.00%;82.35%和77.14%,前者两组比较差异有统计学意义（P〈0.05）,后者两组比较差异无统计学意义（P〉0.05）。结论盐酸多西环素肠溶胶囊联合肤痔清软膏治疗中重度痤疮效果显著,联合应用明显缩短疗程,减少盐酸多西环素肠溶胶囊用量,减少不良反应,值得临床推广。     

大肠平坦型病变靶向活检的病理研究

目的　通过对电子肠镜下大肠平坦型病变的病理学分析,探讨提高大肠早期癌及癌前病变检出率的方法。方法 采用靶向取材活检法,对染色电子肠镜及电子肠镜下黏膜切除术(EMR)送检的标本,进行组织病理诊断,统计学分析,与随机取材组（对照组）作比较。结果 研究组大肠平坦型肿瘤性病变156个, 发现上皮内瘤变和早期癌共53个,检出率为33.33 ％。靶向取材后剩余标本常规包埋切片,相同标本病理诊断相符合共45个,清除病灶8个,病变清除率为 15.09％,p<0.01; 对照组平坦型肿瘤性病变134个 , 发现上皮内瘤变和早期癌14个,检出率为10.4％。两组比较p<0.01。结论 电子肠镜下整体切除靶向活检对发现大肠早期癌及癌前病变,提高检出率具有重要临床意义。     

可变性红斑角化病一例及其家系调查

1病例资料患者男,57岁,因双膝以下皮肤游走性多发红斑50年,加重7年,于2010年8月25日来我院皮肤科就诊。自述7岁时不明诱因双膝以下皮肤出现多个小红点,初如蚊叮咬,皮损逐渐扩大成小片状干燥性红斑,毗邻红斑可融合成片,红斑表面少许鳞屑,边界清晰,自觉痒。皮损呈游走性,曾从踝周延至胫前,并逐渐消退,不留痕迹,     

核因子kB活性与环氧化酶2在胃癌及增生性息肉组织中的表达研究

目的研究胃癌及增生性息肉组织中核因子kB（NF—kB）的DNA结合活性,NF-kBp65及环氧合酶2（COX-2）的表达,通过比较两者表达的差异,从而探讨NF—KB及COX-2在胃癌病程中的意义。方法收集65倒外科手术胃癌及癌旁组织标本,48僦消化内镜下增生性息肉组织标本。采用凝胶迁移滞留试验EMSA检测其NF-kBDNA结合活性,免疫组化SABC法测定其NF—kBp65及COX-2蛋白表达水平。结果胃癌标本NF-kBDNA结合活性更高,可见明显核移位现象,与癌旁组织及增生性息肉组织比较具有统计学差异（P〈0．01）,NF-kBp65在胃癌组织,癌旁组织及增生性息肉中表达阳性率分别为87．7％、10．8％和6．3％,COX-2在胃癌组织,癌旁组织及胃炎中表达阳性率分别为100％,12．3％和10．4％。相关性分析显示胃癌组织中NF-kBp65和COX-2表达呈明显正相关（r=0．6,P〈0．01）。结论NF—kBDNA结合活性及NF—kBp65和COX-2在胃癌组织中阳性表达及DNA显著高于癌旁组织和增生性息肉组织,两者存在明显正相关,推测可能通过干预其活性和表达对胃癌的发生发展过程研究有一定帮助。