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目的 防治小学男生外生殖器异常,掌握患病及卫生状况。方法 检查沈阳市7~14岁小学男生外生殖器,了解其异常、卫生状况及给包茎气囊扩张治疗。对二区36 220例资料卡方检验。结果 患病率;包皮过长56.66%、包茎12.64%随增龄而降低,感染率61.07%较其他疾病高(P<0.01),精索静脉曲张0.27%其患病率随增龄而上升。腹股沟斜疝0.81%、隐睾0.13%、鞘膜积液0.06%、尿道下裂0.02%;包茎外有包皮垢54.8%。治疗包茎2 549例,一次性痊愈率97.37%。结论 包皮过长、包茎是小学生多发病,部分随发育转为正常;外生殖器卫生状况差,缺少卫生保健知识。气囊扩张治疗是降低包茎并发症的必要手段。建议小学校实施男生外生殖器发育监测,保健知识教育。本组调查与治疗结合为包茎及时治疗提供了方便。 相似文献
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Tca-8113细胞系单细胞体外增殖的实验观察 总被引:3,自引:1,他引:2
目的:观察舌鳞癌Tca-8113细胞系的单细胞体外增殖能力,寻找肿瘤干细胞存在的依据,从而为鉴定其表面标记物奠定理论基础。方法:采用有限稀释法对舌鳞癌Tca-8113细胞进行单细胞体外培养,了解舌鳞癌细胞(Tca-8113)的分裂、增殖特点。结果:单细胞培养8d后,舌鳞癌Tca-8113细胞株中具有持续增殖能力的细胞占肿瘤细胞的10.85%,12d后,继续分裂增殖的细胞比例为5.23%,16d后,仅有5.09%的细胞继续增殖。结论:舌鳞癌Tca-8113细胞具有异质性,仅有少量细胞具有持续增殖能力,而这部分细胞是否就是舌鳞癌Tca-8113细胞的肿瘤干细胞。还有待进一步的实验研究证实。 相似文献
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【目的】比较血管紧张素转换酶抑制剂(angiotensin converting engyme inhibitor,ACEI)、血管紧张素Ⅱ受体拮抗剂(angiotensinⅡreceptor blocker,ARB)、钙离子阻断剂(calcium channel blocker,CCB)单独及联合使用对肾脏的保护作用及其机制。【方法】将雌性Wistar大鼠50只随机分成5组,每组10只,其中Ⅰ组为阴性对照组,Ⅱ组为5/6肾切除的阳性对照组,Ⅲ~Ⅴ分别为5/6肾切除术后给予氨氯地平(CCB)、贝那普利(ACEI)+氨氯地平(CCB)及贝那普利(ACEI)+氯沙坦治疗组(ARB)。干预时间为10周,观察治疗后大鼠的血压、蛋白尿、血红蛋白、生化指标的差异。【结果】与Ⅱ组比较,Ⅲ~Ⅴ组均能有效的控制大鼠血压,但各治疗组间疗效差异无统计学意义。Ⅴ组在降尿蛋白方面最佳,其次为Ⅳ组;术后10周,Ⅱ~Ⅴ组大鼠血BUN、Cr浓度较Ⅰ组均明显升高,但组间差异无统计学意义。Ⅳ组大鼠肾脏病理改变最轻。【结论】ACEI、ARB和CCB单独或联合治疗对肾脏均有保护作用,但联合治疗组的肾脏保护作用更好,尤以ACEI联合CCB组肾脏病理改变最轻。ACEI联合ARB治疗对减少蛋白尿作用最强。 相似文献
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Objective To compare the efficacy of high and low dose atorvastatin on preventing contrast induced nephropathy (CIN) in patients underwent diagnostic and therapeutic coronary intervention. Methods All patients received atorvastatin 10 mg/d on the basis of hydrated therapy (n =100) and high dose group received additional atorvastatin 80 nag at 12 to 24 hours before procedure (n =50). Scr, Ccr, blood β2-M, urine NAG/Cr, and urine osmolality before and after the procedure were compared between the groups. Results Baseline demographic characteristics and nephropathy risk factors were similar between groups. Cer was significantly reduced while blood β2-M and uric NAG/Cr were significantly increased in low dose group (all P < 0.05) . Blood β2-M in the high dose group was significantly lower than that in the low dose group at day 1 [(2.35±0.52) mg/L vs. (2.67±0.64) mg/L, P =0.008], day 3[(2.49±0.55)mg/L vs. (2.80±0.64) mg/L,P =0.011] and day 5[(2.29±0.53) mg/L vs. (2.56±0.66) nag/L, P = 0.026] post-procedure respectively; urine NAG/Cr in the high dose group was also significantly lower than that in the low dose group at day 1 [(1.19±0.30) U/mmol vs. (1.46±0.34) U/mmol, P < 0.001], day 3 [(1.30±0.30) U/mmol vs. (1.59±0.33) U/mmol, P < 0.001], and day 5 [(1.10±0.30) U/mmol vs. (1.34±0.35) U/mmol, P = 0.001] post-procedure respectively;Cer in the high dose group was significantly higher than that in the low dose group at day 1 [(73.69±20.99) mL/min vs. (65.19±18.72) mL/min,P =0.035], day 3[(64.04±15.82) ml/min vs. (56.79±14.50)ml/min,P =0.019] post-procedure respectively. Conclusion High dose atorvastatin use before angiography is superior than low dose atorvastatin on attenuating contrast induced renal dysfunction. 相似文献
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Objective To compare the efficacy of high and low dose atorvastatin on preventing contrast induced nephropathy (CIN) in patients underwent diagnostic and therapeutic coronary intervention. Methods All patients received atorvastatin 10 mg/d on the basis of hydrated therapy (n =100) and high dose group received additional atorvastatin 80 nag at 12 to 24 hours before procedure (n =50). Scr, Ccr, blood β2-M, urine NAG/Cr, and urine osmolality before and after the procedure were compared between the groups. Results Baseline demographic characteristics and nephropathy risk factors were similar between groups. Cer was significantly reduced while blood β2-M and uric NAG/Cr were significantly increased in low dose group (all P < 0.05) . Blood β2-M in the high dose group was significantly lower than that in the low dose group at day 1 [(2.35±0.52) mg/L vs. (2.67±0.64) mg/L, P =0.008], day 3[(2.49±0.55)mg/L vs. (2.80±0.64) mg/L,P =0.011] and day 5[(2.29±0.53) mg/L vs. (2.56±0.66) nag/L, P = 0.026] post-procedure respectively; urine NAG/Cr in the high dose group was also significantly lower than that in the low dose group at day 1 [(1.19±0.30) U/mmol vs. (1.46±0.34) U/mmol, P < 0.001], day 3 [(1.30±0.30) U/mmol vs. (1.59±0.33) U/mmol, P < 0.001], and day 5 [(1.10±0.30) U/mmol vs. (1.34±0.35) U/mmol, P = 0.001] post-procedure respectively;Cer in the high dose group was significantly higher than that in the low dose group at day 1 [(73.69±20.99) mL/min vs. (65.19±18.72) mL/min,P =0.035], day 3[(64.04±15.82) ml/min vs. (56.79±14.50)ml/min,P =0.019] post-procedure respectively. Conclusion High dose atorvastatin use before angiography is superior than low dose atorvastatin on attenuating contrast induced renal dysfunction. 相似文献
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目的观察丹参酮ⅡA磺酸钠(STS)对UUO小鼠肾间质纤维化(RIF)的影响及其作用机制。方法清洁级雄性CD1小鼠20只,随机分为:A组(单纯对照组)、B组(UUO造模组)、C组(STS低剂量组)、D组(STS高剂量组)。每组各5只,行右侧输尿管结扎术,单纯对照组只找到输尿管并不结扎,STS组小鼠在手术前3天开始腹腔内注射STS,低、高剂量组STS浓度分别为15 mg/kg.d、30 mg/kg.d,其他2组予同等剂量的生理盐水。UUO 7天后处死小鼠提取肾组织,Masson染色观察肾小管间质胶原纤维分布,Realtime PCR观察肾组织中结缔组织生长因子(CTGF)、Ⅰ型胶原、α-SMA的mRNA表达,Western blot观察肾组织中α-SMA蛋白质表达。结果与对照组相比,UUO小鼠Ⅰ型胶原、α-SMA、CTGF的表达增加,RIF明显(P<0.01),STS可明显抑制UUO小鼠肾组织Ⅰ型胶原、α-SMA、CTGF的表达(P<0.05),减轻RIF。结论 STS具有抑制UUO小鼠肾间质纤维化的作用,且这种作用可能与其对CTGF的抑制有关。 相似文献
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我国老年肺结核是指年龄60岁以上的结核病患者,来源有3种:①原发感染后在肺部遗留下的潜在病灶,当机体抵抗力低下时,潜在性病灶“复燃”属内源性发病。②老年机体抵抗力低下而感染,这属于外源性感染发病。③60岁前患病延续到60岁以后的患者,约占6.7%。老年慢性支气管炎和肺结核是临床上的常见病,其诊断并不困难,但慢 相似文献
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闵睿 《中华国际护理杂志》2004,3(3):212-212
卫生员的培训期限为6个月,他们结业后没有学历,不提干,待遇及工作与一般战士没什么区别。因此,有的学员认为学习卫生员不如学习开车等技术实用,所以,学员对卫生员的学习不够重视,学习兴趣不大。那么,教员在教学实施过程中,如何尽快引导学员进入学习状态,使他们能在有限的时间内, 相似文献
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目的探讨丹参酮ⅡA磺酸钠对TGF-1诱导的人肾小管上皮细胞转分化的影响,为防治肾间质纤维化提供有效的途径。方法人近曲小管上皮细胞株(HKC-8),予TGF-1(2ug/mL)刺激48或72h,同时给予丹参酮ⅡA磺酸钠(终浓度分别为0.5、1.0、2.0、4.0mg/mL)进行干预,采用real time PCR、western blot及间接免疫荧光等方法检测平滑肌激动蛋白(α-SMA)、纤维连接蛋白(FN)、ZO-1(zonulaocclundents protein-1)、结缔组织生长因子(CTGF)的表达。结果与对照组比较,TGF-1明显上调α-SMA、FN、CTGF的表达,抑制ZO-1的表达(P〈0.01),丹参酮ⅡA磺酸钠以浓度依赖方式抑制TGF-1介导的α-SMA、FN、CTGF上调,恢复ZO-1的表达(P〈0.05)。结论丹参酮ⅡA磺酸钠能逆转TGF-1诱导的人肾小管上皮细胞转分化,因而具有防治肾间质纤维化的作用。 相似文献