16α-甲基-3β,17α-二羟基-5α-孕甾-20酮-3β-醋酸酯的微生物转化

16 α-Methyl-3 β,17 α-dihydroxy-5 α-pregnane-20-one-3 β-acetate (Ⅰ) was prepared from tigogenin and then incubated with a mixture of Mycobacterium smegmatis (MS₁) and Arthrobacter simplez (A₁) to give 16 α-methyl-17 α-hydroxy-△^{1, 4}-pregnadiene-3,20-dione (Ⅱ) with about 63% yield.Compound (Ⅱ) when incubated with Absidia glauca (AG₁) gave about 55% yield of 16 α-methyl-11 α, 17 α-dihydroxy-pregna-1,4-diene-3,20-dione (Ⅳ).     

16α-甲基-3β,17α-二羟基-5α-孕甾-20酮-3β-醋酸酯的微生物转化

目前我国是以蕃麻皂素(hecogenin)为起始原料合成高效皮质激素(地塞米松)的。但我国两广、福建等省多种植长纤维的“东一号”剑麻,从其叶汁中所制得的是蕃、剑麻皂素的混合物,其中蕃麻皂素仅占20～30%,而剑麻皂素(tigogenin),却占70～80%,且未能