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2-(E)-(3-甲氧基-4-羟基苯亚甲基)-5-(N-取代胺甲基)环戊酮的合成及抗炎活性研究 总被引:1,自引:0,他引:1
In search for new antiinflammatory agents, a series of 2-(E)-(4-hydroxy-3-methoxybenzylidene)-5-(N-substituted aminomethyl) cyclopentanones was synthesized via Stork reaction, Mannich reaction and amine exchange reaction. All of the fifteen target compounds were characterized by spectral analysis and elemental analysis. Preliminary pharmacological tests showed that several target compounds exerted appreciable effect on xylene-induced ear edema in mice and that alteration of the substituents of anilines showed significant influence on antiinflammatory potency. 相似文献
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本文合成了15种2(E)(3甲氧基4羟基苯亚甲基)环戊酮杂环胺Mannich碱盐酸盐和芳胺Mannich碱,并进行了初步的抗炎活性筛选。所有化合物结构均经波谱分析和元素分析证实。药理试验结果表明:部分化合物对二甲苯致小鼠耳肿胀有较显著的抑制作用;苯胺取代基的变化对芳胺Mannich碱的抗炎活性有显著的影响。 相似文献
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