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目的:探讨喘可治注射液治疗支气管哮喘(简称哮喘)的作用机制.方法:60只雄性Wistar大鼠随机分为正常组、模型组、地塞米松组(0.5 ml·kg-1 ·d-1,肌内注射),高、中、低剂量(10、5、2.5 ml·kg-1·d-1,腹腔注射)喘可治注射液组.以2%卵蛋白为激发液,雾化吸入致敏,建立哮喘模型.治疗后,大鼠肺叶经HE染色后行病理切片,采用酶联免疫吸附(ELISA)法分别测定大鼠外周血中白介素-4(IL-4)和γ-干扰素(IFN-γ)浓度,采用流式细胞仪测定大鼠外周血中CD4+ CD25+T调节细胞和CD3- CD161a+自然杀伤(NK)细胞占淋巴细胞的百分比.结果:各剂量喘可治注射液组大鼠肺叶局部炎症反应均较模型组轻,IL-4浓度均明显下降,与模型组相比差异有显著性(P<0.01),但各治疗组间、治疗组和正常组间IL-4浓度无显著差异.各治疗组IFN-γ的浓度均较模型组有所上升,其中高剂量组上升最为明显,与模型组比较有显著差异(P<0.01).高、中、低剂量喘可治注射液组CD4+ CD25+T调节细胞百分比均明显上升,与模型组相比有显著差异(P<0.05).CD3- CD161.+ NK细胞的百分比各组间比较无显著性差异.结论:喘可治注射液可增加血中IL-4、IFN-γ浓度,及CD4+ CD25+T调节细胞含量,纠正免疫失衡,这可能是其治疗哮喘的机制之一. 相似文献
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Objective To further understand the clinic manifestations of childhood primary Sjogren's Syndrome(pSS) and enhance early diagnosis. Methods Five cases of pSS from Renji Hospital, Shanghai, were reported and their clinical features were analysoed. And literatures from Medline database and Weipu database were reviewed and discussed. Results ①Childhood pSS had various clinic presentations that were non-specific and sicca symptoms were absent or occur late in most cases. ② The most common presentations were recurrent parotiditis and cutaneous manifestations with various locations and forms. ③ American-European Criteria for SS were not suitable for the diagnosis of childhood pSS. Conclusion Recurrent parotiditis and cutaneous manifestations in children can be used as clues for the diagnosis of childhood pSS but needs to be further confirmed by the positive results of salivary gland biopsy and autoantibodies examination, particularly SSA/SSB. 相似文献
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Objective To further understand the clinic manifestations of childhood primary Sjogren's Syndrome(pSS) and enhance early diagnosis. Methods Five cases of pSS from Renji Hospital, Shanghai, were reported and their clinical features were analysoed. And literatures from Medline database and Weipu database were reviewed and discussed. Results ①Childhood pSS had various clinic presentations that were non-specific and sicca symptoms were absent or occur late in most cases. ② The most common presentations were recurrent parotiditis and cutaneous manifestations with various locations and forms. ③ American-European Criteria for SS were not suitable for the diagnosis of childhood pSS. Conclusion Recurrent parotiditis and cutaneous manifestations in children can be used as clues for the diagnosis of childhood pSS but needs to be further confirmed by the positive results of salivary gland biopsy and autoantibodies examination, particularly SSA/SSB. 相似文献
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Objective To further understand the clinic manifestations of childhood primary Sjogren's Syndrome(pSS) and enhance early diagnosis. Methods Five cases of pSS from Renji Hospital, Shanghai, were reported and their clinical features were analysoed. And literatures from Medline database and Weipu database were reviewed and discussed. Results ①Childhood pSS had various clinic presentations that were non-specific and sicca symptoms were absent or occur late in most cases. ② The most common presentations were recurrent parotiditis and cutaneous manifestations with various locations and forms. ③ American-European Criteria for SS were not suitable for the diagnosis of childhood pSS. Conclusion Recurrent parotiditis and cutaneous manifestations in children can be used as clues for the diagnosis of childhood pSS but needs to be further confirmed by the positive results of salivary gland biopsy and autoantibodies examination, particularly SSA/SSB. 相似文献
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大剂量MTX治疗儿童ALL副作用防治研究 总被引:5,自引:0,他引:5
目的研究大剂量甲氨蝶呤(methotrexate,MTX)对急性淋巴细胞性白血病患儿的中枢神经系统白血病的预防,观察其毒副作用。方法13例ALL患儿接受57例次HD-MTX(每次3.0g/m^2)治疗。经综合预防措施后,观察临床症状、体征和实验室指标,总结HD-MTX的副作用发生种类、发生率及临床疗效。结果13例ALL中11例未发生CSNL,2例治疗中出现CNSL,经治疗后CR,现仍处于CCR中。13例平均CCR 31.8个月。结论儿童对HDMTX耐受性好,HD-MTX可以有效预防ALL的CNSL复发,提高长期无病生存率。 相似文献
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Objective To further understand the clinic manifestations of childhood primary Sjogren's Syndrome(pSS) and enhance early diagnosis. Methods Five cases of pSS from Renji Hospital, Shanghai, were reported and their clinical features were analysoed. And literatures from Medline database and Weipu database were reviewed and discussed. Results ①Childhood pSS had various clinic presentations that were non-specific and sicca symptoms were absent or occur late in most cases. ② The most common presentations were recurrent parotiditis and cutaneous manifestations with various locations and forms. ③ American-European Criteria for SS were not suitable for the diagnosis of childhood pSS. Conclusion Recurrent parotiditis and cutaneous manifestations in children can be used as clues for the diagnosis of childhood pSS but needs to be further confirmed by the positive results of salivary gland biopsy and autoantibodies examination, particularly SSA/SSB. 相似文献
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Objective To further understand the clinic manifestations of childhood primary Sjogren's Syndrome(pSS) and enhance early diagnosis. Methods Five cases of pSS from Renji Hospital, Shanghai, were reported and their clinical features were analysoed. And literatures from Medline database and Weipu database were reviewed and discussed. Results ①Childhood pSS had various clinic presentations that were non-specific and sicca symptoms were absent or occur late in most cases. ② The most common presentations were recurrent parotiditis and cutaneous manifestations with various locations and forms. ③ American-European Criteria for SS were not suitable for the diagnosis of childhood pSS. Conclusion Recurrent parotiditis and cutaneous manifestations in children can be used as clues for the diagnosis of childhood pSS but needs to be further confirmed by the positive results of salivary gland biopsy and autoantibodies examination, particularly SSA/SSB. 相似文献
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儿童风湿病是一组自身免疫性疾病,主要累及结缔组织和血管.由于肺脏具有丰富的结缔组织和血管,风湿病常伴有肺间质病变,预后极差.儿童风湿病更易发生肺间质病变,而且以亚临床型多见,但能通过影像学等检查早期发现,及时治疗可改善预后.现主要介绍儿童风湿病相关性肺间质病变的流行病学、临床表现、诊断、影像学表现和病理基础、治疗及预后. 相似文献