阿伐他汀激活wnt/β-catenin信号通路促进骨质疏松模型大鼠移植物的骨整合

BACKGROUND: Atorvastatin has been shown to reduce bone loss and fracture, but its effects on implant osseointegration remain unknown. OBJECTIVE: To investigate the effects of atorvastatin on implant osseointegration in osteoporotic rats and the underlying mechanisms. METHODS: Forty-eight Sprague-Dawley rats were randomized into sham-surgery, ovariectomy, and atorvastatin (10 and 20 mg/kg per day) treatment groups, respectively. All rats received ovariectomy and implant surgery except those in the sham-surgery group. Bone mineral density of the lumbar vertebra, osseointegration ratio and pull-out strength of implants were measured after 12-week treatment. Levels of bone formation and resorption markers in osteoblasts treated with atorvastatin were determined by ELISA. Wnt pathway-related gene expression was detected by RT-PCR. RESULTS AND CONCLUSION: Bone mineral density, osseointegration ratio and pull-out strength of implants were significantly increased in 20 mg/kg per day of atorvastatin treatment group compared with ovariectomy group (P < 0.05). Levels of alkaline phosphatase, osteocalcin and osteoprotegerin were significantly increased in osteoblasts treated with atorvastatin in vitro (P < 0 .05), and the level of osteoclast differentiation factor RANKL was significantly inhibited (P < 0.05). Meanwhile, atorvastatin significantly promoted the mRNA expression of low-density lipoprotein associated protein 5 and β-catenin, and inhibited the mRNA expression of dickkopf Wnt signal pathway inhibitor 1 and sclerostin. Our results suggest that atorvastatin promotes implant osseointegration in osteoporotic rats by activating Wnt/β-catenin signal pathway. 中国组织工程研究杂志出版内容重点：组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程     

自动化智能药柜在神经科病区的应用及效果分析

目的 探讨自动化智能药柜在神经科病区的应用效果,为创建信息化药品管理模式提供参考。方法 对比智能药柜应用前后的使用资料,分析自动化智能药柜在神经科病区的应用效果。结果 应用智能药柜后,药师备药时间、护士执行医嘱时间、退药时间、临嘱摆药次数均明显缩短(P<0.05),但临时医嘱退药次数无明显差异(P>0.05)。在安全性方面,智能药柜有效降低与取药相关错误(P<0.05),且未增加用药差错。在满意度方面,护士及药师对其应用效果的总体满意率达93.18%。在成本方面,总节省成本为6945.72(5556.57～8272.49)元/月。结论 自动化智能药柜的应用可以优化病区的药品管理模式,提高医务人员的工作效率,保证危重患者用药的及时性。     

临床药师参与1例利奈唑胺引发的周围神经炎患者的药学实践

临床药师参与1例利奈唑胺致周围神经炎不良反应的分析和监护,以期引起临床重视,减少严重不良反应发生。临床药师根据药物引发周围神经炎的时间相关性和药物与不良反应因果关系的判断准则,建议临床停用利奈唑胺,患者周围神经炎好转。临床药师积极参与临床治疗实践,可保障患者用药安全,促进临床合理用药。