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埃索美拉唑静脉滴注治疗非静脉曲张性上消化道出血的疗效观察 总被引:1,自引:0,他引:1
目的:评估埃索美拉唑40mg静脉注射治疗急性非静脉曲张性上消化道出血的疗效和安全。方法:对内镜证实的25例急性非静脉曲张性上消化道出血征象的患者,随机、双盲分为埃索关拉唑组(n=19)和奥美拉唑组(n=6),实验组和对照组分别给予埃索美拉唑和奥美拉唑40mg q12h静脉滴注,治疗5d。观察72h及120h的临床止血疗效及药物不良事件。结果:治疗72h两组临床上无消化道出血征象受试者百分率无显著性差异(P〉0.05)。治疗120h有效率两组均为100%。中位止血时间埃索关拉唑组为41h,奥美拉唑组为20h,两组比较无显著性差异(P〉0.05)。不良事件发生情况两组相似,均无与药物有关的严重不良事件发生。结论:静脉给予埃索美拉唑治疗急性非静脉曲张性上消化道出血疗效不劣于奥美拉唑,和奥美拉唑相比也有很好的耐受性。 相似文献
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Objective To evaluate the possible association between depression and cellular immunologic status in patients with verruca planea. Methods Depression was assessed with the Self-rating Depression Scale (SDS), and the inteleukin-2 (IL-2)produced by peripheral blood mononuclear cells (PBMC) and the activity of natural killer (NK) cells were measured in 68 patients with verruca planea. Results The SDS scores in patients with verruca planea(46. 08 ± 12.76) were significantly higher than those in the controls(41.88 ± 10. 57, t = 3.71, P < 0. 01 ), and 38% of the patients were affected by depression. The mean scores of depression (48.89 ± 11. 52 ) and the rate ( 29% ) of depressive disorder among patients unmarried (single) were significantly higher than those married [(43. 16 ± 10. 17 ), 9%;t = 2. 28, x2 = 4. 86, P < 0. 05] . The mean scores of depression among female patients (49. 01 ± 11.36 )were significantly higher than male patients [(41.96 ± 10.48 ) ,t =2. 21 ,P <0. 05] . In patients affected by depression, the level of the IL-2[(46. 64 ± 12. 28) × 103 U/L] produced by PBMC and the activity of NK cells[( 19. 23 ±5.60)%] were significantly decreased than those in undepressive group[(56. 15 ± 18. 32) ×103 U/L, (24.65 ± 6. 89)%; t = 3.18, 3. 32, P < 0.01] . The differences above were all significant. Conclusions Patients with vermca planea are partly affected by depression and the cellular immunologic status may be abnormal among the patients with depression. 相似文献
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注意缺陷多动障碍儿童的智力结构及社会适应行为特点 总被引:2,自引:0,他引:2
背景注意缺陷多动障碍(
attention deficit hyperactivity disorder,ADHD)患儿注意力不集中常给学习带来困难,影响学习成绩.近年来关于
ADHD儿童的智能发育及社会适应方面的研究不少,但结论不一致. 目的探讨
ADHD儿童智力结构及社会适应行为特点. 设计以诊断为依据的病例对照研究.
方法选取 ADHD 患儿 48例,健康儿童 48例,利用韦氏学龄智力量表和社会适应行为评定量表评定其智力和社会适应能力,比较其智力结构和适应行为特点.
结果智力方面 ADHD患儿言语智商 (101.23± 7.45)高于其操作智商 (89.72±
8.00),差异有显著性意义 (t=2.241,P< 0.05), ADHD患儿言语、操作及总智商
(101.23± 7.45 ,89.72± 8.00, 94.12± 10.28)均低于对照组相应智商 (105.46± 8.70,
102.85± 9.36, 104.20± 8.57),差异有显著性意义 (t=2.360,2.547,2.012, P< 0.05);不分心因子和获得因子得分
(16.10± 3.86, 25.47± 5.01)低于对照组 (20.00± 3.94, 29.33± 4.46),差异有显著性意义
(t=2.764, 3.223,P< 0.01),社会适应方面 ADHD患儿独立功能因子得分和认知因子得分
(61.20± 6.14, 56.80± 5.86)高于对照组( 51.66± 5.47 ,48.24± 4.98),差异有显著性意义
(t=2.560, 2.589,P< 0.05 ),而社会 /自制因子得分 (40.32± 6.22)低于对照组
(57.86± 6.03) 差异有显著性意义 (t= 2.412, P< 0.05). 结论 ADHD患儿智力结构和社会适应能力存在缺陷,积极防治对于保证其智力发育和社会适应能力的提高具有重要意义. 相似文献
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性传播疾病 (性病 )是当前社会上流行极为广泛的一类传染性疾病。性病 ,特别是艾滋病的出现与迅速传播 ,已引起世界各国政府的高度重视和社会的广泛关注。性病不仅在经济发达的国家发病率较高 ,而且在许多发展中国家的发病率也在不断增高。近几年来 ,我院性病科门诊每天接诊性病病人少则 3~ 4例 ,多则 10余例 ,就诊病人年龄多在 2 0~5 0岁 ,而老年就诊病人也时有发现。为指导性病病人正确认识性病 ,避免乱求医、滥用药、延误诊治 ,影响性病病人的身体康复 ,以及减少性病在社会上的蔓延 ,除对性病病人进行正常的治疗外 ,还要对他们进行心理… 相似文献
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目的 探讨扁平疣患者抑郁情绪障碍与细胞免疫功能的关系.方法 采用自评抑郁量表(SDS)对68例扁平疣患者抑郁情绪进行评定,并比较分析有无抑郁的扁平疣患者外周血单一核细胞产生白介素-2(IL-2)的能力和天然杀伤(NK)细胞活性.结果 扁平疣患者的SDS标准分显著高于全国常模[(46.08±12.76)分vs(41.88±10.57)分;t=3.71,P<0.01],差异有统计学意义.抑郁障碍的发生率为38%(26例).扁平疣患者中未婚者SDS标准分(48.89±11.52)分,抑郁发生率29%(20例),已婚者SDS标准分(43.16±10.17)分,抑郁发生率9%(6例),差异有统计学意义(t=2.28,x2=4.86,P<0.05).女性患者SDS标准分(49.01±11.36)分,男性(41.96±10.48)分,差异有统计学意义(t=2.21,P<0.05).具有抑郁情绪障碍者外周血单一核细胞产生IL-2的能力、NK细胞活性分别为(46.64±12.28)×103U/L、(19.23±5.60)%,低于无抑郁情绪患者[(56.15±18.32)×103 U/L、(24.65±6.89)%,t=3.18、3.32,P<0.01].结论 部分扁平疣患者存在明显的抑郁情绪障碍,且抑郁者多伴有细胞免疫功能异常.Abstract: Objective To evaluate the possible association between depression and cellular immunologic status in patients with verruca planea. Methods Depression was assessed with the Self-rating Depression Scale (SDS), and the inteleukin-2 (IL-2)produced by peripheral blood mononuclear cells (PBMC) and the activity of natural killer (NK) cells were measured in 68 patients with verruca planea. Results The SDS scores in patients with verruca planea(46. 08 ± 12.76) were significantly higher than those in the controls(41.88 ± 10. 57, t = 3.71, P < 0. 01 ), and 38% of the patients were affected by depression. The mean scores of depression (48.89 ± 11. 52 ) and the rate ( 29% ) of depressive disorder among patients unmarried (single) were significantly higher than those married [(43. 16 ± 10. 17 ), 9%;t = 2. 28, x2 = 4. 86, P < 0. 05] . The mean scores of depression among female patients (49. 01 ± 11.36 )were significantly higher than male patients [(41.96 ± 10.48 ) ,t =2. 21 ,P <0. 05] . In patients affected by depression, the level of the IL-2[(46. 64 ± 12. 28) × 103 U/L] produced by PBMC and the activity of NK cells[( 19. 23 ±5.60)%] were significantly decreased than those in undepressive group[(56. 15 ± 18. 32) ×103 U/L, (24.65 ± 6. 89)%; t = 3.18, 3. 32, P < 0.01] . The differences above were all significant. Conclusions Patients with vermca planea are partly affected by depression and the cellular immunologic status may be abnormal among the patients with depression. 相似文献
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胸腺肽对扁平疣患者血清白介素-10和γ干扰素水平的影响及疗效分析 总被引:2,自引:0,他引:2
目的研究胸腺肽对扁平疣患者血清白介素-10(IL-10)、γ干扰素(IFN-γ)水平的影响及疗效.方法采用酶联免疫吸附实验(enzyme-linked immunosorbent assay,ELISA)双抗体夹心技术检测扁平疣患者治疗组、对照组治疗前后及正常人血清IL-10、IFN-γ水平.结果治疗前两组扁平疣患者IL-10水平都明显高于正常人,IFN-γ水平明显低于正常人(P<0.01),两组患者间IL-10、IFN-γ水平相近(P>0.05).治疗后胸腺肽组IL-10水平显著降低,并明显低于对照组,IFN-γ水平显著升高,也明显高于对照组(P<0.01),而对照组治疗前后水平差异无统计学意义(P>0.05),且治疗组的疗效(总有效率80.76%)明显高于对照组的46.15%(P<0.05).结论扁平疣患者存在TH1/TH 2型细胞因子失衡,胸腺肽可通过纠正此种细胞因子失衡而改善患者免疫功能,提高治疗效果. 相似文献
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酒渣鼻是一种常见的损容性皮肤病,其发生与性激素分泌紊乱密切相关。我们以外用自制氯灭酊作对照,采用内服螺内酯并外用氯灭酊对27例女性酒渣鼻患者进行试治,并用放射免疫法测定了其中的20例患者治疗前后血中睾酮和雌二醇水平的变化,现报告如下。 相似文献
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注意缺陷多动障碍儿童的智力结构及社会适应行为特点 总被引:1,自引:0,他引:1
背量:注意缺陷多动障碍(attention deficit hyperactivity disonter,ADHD)患儿注意力不集中常给学习带来困难,影响学习成绩。近年来关于ADHD儿童的智能发育及社会适应方面的研究不少,但结论不一致。目的:探讨ADHD儿童智力结构及社会适应行为特点。设计:以诊断为依据的病例对照研究。方法:选取ADHD患儿48例,健康儿童48例,利用韦氏学龄智力量表和社会适应行为评定量表评定其智力和社会适应能力,比较其智力结构和适应行为特点。结果:智力方面ADHD患儿言语智商(101.23&;#177;7.45)高于其操作智商(89.72&;#177;8.00),差异有显著性意义(t=2.241,P&;lt;0.05),ADHD患儿言语、操作及总智商(101.23&;#177;7.45,89.72&;#177;8.00,94.12&;#177;10.28)均低于对照组相应智商(105.46&;#177;8.70,102.85&;#177;9.36,104.20&;#177;8.57),差异有显著性意义(t=2.360,2.547,2.012,P&;lt;0.05);不分心因子和获得因子得分(16.10&;#177;3.86,25.47&;#177;5.01)低于对照组(20.00&;#177;3.94,29.33&;#177;4.46),差异有显著性意义(t=2.764,3.223,P&;lt;0.01),社会适应方面ADHD患儿独立功能因子得分和认知因子得分(61.20&;#177;6.14,56.80&;#177;5.86)高于对照组(51.66&;#177;5.47,48.24&;#177;4.98),差异有显著性意义(t=2.560,2.589,P&;lt;0.05),而社会/自制因子得分(40.32&;#177;6.22)低于对照组(57.86&;#177;6.03)差异有显著性意义(t=2.412,P&;lt;0.05)。结论:ADHD患儿智力结构和社会适应能力存在缺陷,积极防治对于保证其智力发育和社会适应能力的提高具有重要意义。 相似文献