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目的探讨NK细胞活化受体(NKG2D)及调节性T细胞(Treg cells)在食管癌患者外周血中表达水平及其临床意义。方法采用流式细胞术检测140例食管癌患者及51例健康者外周血NKG2D表达率、及调节性T细胞占CD4+T百分比,分析研究各细胞表达与食管癌临床TNM分期及调节性T细胞与NKG2D相关性。结果食管癌外周血NKG2D表达小于健康者(P〈0.001);调节性T细胞表达大于健康者(P〈0.001)。NKG2D与调节性T细胞呈负相关性(r=-0.346,P〈0.001)。NKG2D表达总变异的12%与调节性T细胞有关(R2=0.120)。结论食管癌患者外周血调节性T细胞、NKG2D表达均与临床TNM分期有关。调节性T细胞抑制了NKG2D介导的NK细胞抗肿瘤功能。 相似文献
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目的:探讨医学生志愿者对首发老年脑卒中病人居家康复的支持效果,为构建首发老年脑卒中病人居家康复的支持系统提供参考.方法:采用便利抽样法抽取山西省汾阳市西河社区的32例首发老年脑卒中病人为研究对象,医学生志愿者于首次进行居家访视时采用一般情况调查表、中文版Fugl-Meyer运动功能评定量表(FMA)、Barthel指数(BI)评分量表、综合性医院焦虑抑郁量表(H AD)对研究对象进行全面评估,团队协作制定干预方案,根据病人的实际情况1~2周对其进行1次干预,6个月后再次对其进行评估.结果:干预6个月后32例首发老年脑卒中病人FMA、BI得分均高于干预前,HAD得分低于干预前,差异有统计学意义(P<0.05).结论:医学生志愿者参与首发老年脑卒中病人的居家康复可提高脑卒中病人运动功能及日常生活活动能力,改善其心理状况.建议构建医学生志愿者参与首发老年脑卒中病人居家康复的支持系统,为首发老年脑卒中病人居家康复提供系统的支持. 相似文献
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目的检测不同临床分期肾癌患者外周血CD4+T细胞、CD8+T细胞中细胞因子的表达水平,分析Th1/Th2及Tc1/Tc2漂移对肾癌发生和转移的临床意义。方法用流式细胞仪检测60例不同分期肾癌患者和40例正常对照者外周血CD4+T细胞、CD8+T细胞分泌的IFN-γ、IL-2、TNF-α、IL-4、IL-6和IL-10的表达水平。结果与正常对照组相比,无症状型肾癌患者各细胞因子的表达无明显差异,而局限型患者Th1、Tc1类细胞因子IFN-γ、IL-2和TNF-α分泌水平降低(P<0.01),局部进展型和转移型肾癌患者Th1、Tc1类细胞因子IFN-γ、IL-2和TNF-α分泌水平明显下降(P<0.01);而Th2、Tc2类细胞因子IL-4、IL-6(P<0.05,P<0.01)分泌水平升高。结论 Th1/Th2偏移和Tc1/Tc2偏移促进了晚期肾肿瘤的进展和转移。T淋巴细胞亚群改变导致免疫功能失调,使肿瘤细胞发生免疫逃逸。 相似文献
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目的观察非小细胞肺癌患者外周血淋巴细胞亚群CD3+CD4+和CD3+CD8+及其表面受体NKG2D、NKG2A的表达水平,分析其表达水平与肺癌肿瘤免疫逃逸的相关性。方法采集34例肺癌患者外周血,按照TNM分期分为早期组(Ⅰ期和Ⅱ期)和晚期组(Ⅲ期、Ⅳ期),用流式细胞仪检测外周血,分析淋巴细胞亚群CD3+CD4+和CD3+CD8+及其表面受体NKG2D、NKG2A的表达及相关性。结果晚期组CD3+CD4+的表达水平较早期组降低,而CD3+CD8+的表达水平升高(P<0.05);晚期组肺癌患者CD3+CD4+NKG2D表达率(6.69±3.58%)高于早期组的表达率(2.38±1.13%),CD3+CD4+NKG2A表达率(2.28±0.88%)低于早期组的表达率(5.46±2.09%)(P<0.01);晚期组肺癌患者CD3+CD8+NKG2D表达率(90.57±2.49%)低于早期组的表达率(93.51±3.19%),CD3+CD8+NKG2A表达率(12.32±4.24%)高于早期组的表达率(7.15±3.30%)(P<0.01)。结论非小细胞肺癌病理分期间淋巴细胞亚群CD3+CD4+和CD3+CD8+表达水平的改变,NKG2D、NKG2A在CD3+CD4+和CD3+CD8+表面的表达失衡,可能是肿瘤免疫逃逸的机制之一。 相似文献
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Objective To evaluate the clinical diagnostic application and operative efficacy of the expression of NKG2D in peripheral blood CD+8 NKT cell and its ligand sMICA in patients with esophageal or cardiac carcinoma.Methods The peripheral blood NKG2D positive CD+8 NKT cell percentage was concomitantly determined by flow cytometry in 53 preoperative patients including 29 postoperative patients with esophageal or cardiac carcinoma and 30 healthy controls.The serum sMICA was determined by ELISA.Results The peripheral blood NKG2D positive CD+8 NKT cell percentage in patients was significantly lower than that in controls [(77.632±8.972) % vs (89.053±6.515) %] (t = -6.113,P <0.05); with stage Ⅱ,Ⅲ,Ⅳ,it decreased significantly in order (F = 99.251,P <0.01);with lymph node metastasis lower than that without lymph node metastasis (t = -10.384,P <0.01); squamous carcinoma was higher than adenocarcinoma (t =9.899,P <0.01); postoperative was significantly higher than preoperative (t =-4.319,P <0.01).The level of serum sMICA in patients was significantly higher than that in controls [(326.28±85.407) pg/ml vs (210.00±92.560) pg/ml](t =7.292,P <0.01); with stage Ⅱ,Ⅲ,Ⅳ,it increased significautly in order (F =63.355,P <0.01); with lymph node metastasis higher than that without lymph node metastasis (t =7.770,P <0.01); squamous carcinoma was lower than adenocarcinoma (t =-7.593,P<0.01); postoperative was significantly lower than preoperative (t =7.027,P <0.01).Serum sMICA could inhibit peripheral blood CD+8 NKT cell activation receptor NKG2D (F =142.773,P <0.05),determination coefficient R2 = 0.7368.Conclusion The level of peripheral blood CD+8NKT cell activation receptor NKG2D and serum sMICA in patients could be an assistant indicator for 相似文献