甘草酸单铵对体外培养人和大鼠淋巴细胞前列腺素和DNA合成的影响

本文测定了不同浓度的甘草酸单铵(AG)对体外培养人和大鼠淋巴细胞的~3H胸腺嘧啶核苷(~3HTdR)参入抑制率及PGI_2和TXA_2合成的影响。结果表明:AG在1.5×10~(-7)和3×10~(-7)时增加~3HTdR参入抑制率。利用RIA方法测定了AG对淋巴细胞PGI_2和TXA_2的影响,发现在4×10~(-7)mol/L、4×10~(-8)mol/L和4×10~(-11)mol/L的AG作用下,可显著降低TXA_2的释放,而对PGI_2的释放无显著影响。     

服用他汀少吃葡萄

他汀类药物确实有显著的降血脂作用，但使用时不应像服用一般保健药那样放心，要听医师的指导。西立伐他汀（拜斯亭）引发横纹肌溶解而致死的事件已引起人们的注意。国外最新报道说：一位６７岁女性因服阿托伐他汀出现剧烈头痛、腹泻等严重不良反应。经追访，其原因如下：患者二十多年来每日早餐服葡萄汁，已成了习惯，近来因血脂高，医生嘱咐按常规剂量服用阿托伐他汀（Ａｆｎｏｖａｓａｔａｔｉｎ）。她服药后出现剧烈头痛及腹泻，遵医嘱停服降血脂药后，不良反应即消失。澳大利亚药物不良反应中心专家研究认为，这可能是他汀类药与葡萄汁…     

PHARMACOLOGICAL RESEARCH ON THE EFFECT OF LICORICE

Licorice is extracted from the roots and sto-lons of Glycyrrhiza uralensis Fisch,a plant initial-ly cultivated for its medical value as describedvery early in“Compendium of Materia Medica”(Li Shizhen).In 1760 a certain George Dunhilladded sugar to licorice,creating a popular con-fection.Licorice is widely used as a flavoringagent in foods,beverages,tobacco and some me-dications.Further studies of its effective com-ponents and mechanisms of action have beenmade only recently,however,with the develop-ment of modem medical techniques.