丁苯酞注射液治疗频发型TIA疗效观察

目的观察丁苯酞注射液治疗频发短暂性脑缺血发作(TIA)的临床疗效。方法选取46例TIA患者,随机分为治疗组23例和对照组23例,2组在抗血小板聚集等基础治疗上无差异,治疗组另给予丁苯酞氯化钠注射液100mL,2次/d,疗程为14d。结果治疗组疗效明显优于对照组,2组总有效率比较差异有统计学意义(P0.05),且无明显不良反应。结论丁苯酞注射液对治疗频发TIA疗效确切。     

痴呆与颅内动脉血管狭窄相关性分析

目的探讨利用磁共振血管成像(MRA)技术手段分析颅内动脉血管狭窄与痴呆的相关性。方法选择经磁共振血管成像(MRA)检查的痴呆患者118例作为观察组,同时选择120例健康体检者作为对照组,观察比较两组间颅内动脉血管狭窄的发生率。结果观察组共有105例存在颅内动脉血管狭窄,发生率与对照组相比,差异有统计学意义(P0.05)。与对照组相比,观察组颅内血管中度狭窄发生率较高,有统计学意义(P0.05);观察组颅内血管重度狭窄发生率较对照组高,差异有明显的统计学差异(P0.01);观察组颅内血管轻度狭窄发生率与对照组无明显差异(P0.05)。结论痴呆与颅内动脉血管狭窄有关,痴呆患者颅内动脉血管狭窄的发生率较高。     

南阳市外出务工青年脑卒中病因及危险因素分析

目的：分析南阳市外出务工青年脑卒中的病因及危险因素。方法选用南阳市区5家三级医院的中青年住院患者,分析疾病种类、是否外出务工、既往病史、家族史、实验室检测因子、务工情况等。结果南阳市外出务工青年住院病人中脑卒中占18.6％,非外出务工青年住院中脑卒中占14.1％,南阳市青年卒中病例中外出务工青年比例为60.3％,南阳市外出务工青年卒中发病率高于普通人群的危险因素主要为工种及工作环境等。结论外出务工青年脑卒中发病率明显高于普通人群,工作环境污染、长期吸烟、大量饮酒、生活不规律、心理压力等是外出务工青年急性脑卒中的主要发病原因及危险因素。     

39例Loffler综合征临床诊断及误诊分析

Lofffler综合征是1932年由Loffler报道提出的一种特殊肺炎,是由蛔虫感染引起的嗜酸细胞浸润性肺炎[1].由于小儿蛔虫感染率较高,加之小儿肺部发育特点及免疫因素,因而该病并非罕见,足以引起儿科医师的重视.我科自1992～1999年间诊治39例Loffler综合征,从而总结出不少经验,并提高了小儿呼吸系统疾病诊断的正确率.现分析如下.     

复发性脑梗死患者颈动脉狭窄、超敏C反应蛋白含量的观察

脑梗死是中青年人群的常见病、多发病,如何防止其发生及复发一直是医疗界面临的难题.近年研究发现其发生与颈动脉狭窄及超敏C反应蛋白有关,但脑梗死复发与其相关的报道较少.     

转化生长因子β_1基因标签单核苷酸多态性与新疆汉族原发性高血压相关性研究

Objective Essential hypertension (EH) was a complex disease resulted from the interaction of cumulative effect of multiple genetic and environment factors. The relationship between the genetic polymorphisms in the transforming growth factor-β_1 ( TGF-β_1 ), the blood levels and EH have been investigated, but the conclusions were different. Therefore, we investigate the relationship between the tagging single nucleotide polymorphisms (tSNPs) ( rs1800469, rs2241716, rs11466345, rs2241715,rs4803455) in TGF-β_1 gene, blood levels and EH in the Han nationality population in Xinjiang, to clarity the pattern of linkage disequilibrium (LD) and the feature of the structure of haplotype. Methods Based on the case-control study,we selected 732 (365 EH patients,367 controls) Han Chinese population from the Boertonggu countryside of Shawan region in the Xinjiang Uygur Autonomous Region of China by random cluster sampling. After questionnaire and physical examination, we collected blood samples, and the blood levels of TGF-β_1, were quantified using sandwich ELISA. The polymorphisms of TGF-β_1 gene in the study groups were detected with SNaPshot system. The case-control study in a large group was carried out separately for each of the tSNP and followed up by haplotypes analyses to determine the relation between tSNPs of TGF-β_1 gene and EH in the Han population. Results ( 1 ) The frequencies of alleles A, G of rs11466345 of TGF-β_1, gene in EH group and control group were as follows: 69.7%, 30. 3% ,74.4%,25.6%, respectively. It was demonstrated that the G allele of the rs11466345 polymorphism occurred at a significantly higher frequency in EH patients than in healthy controls (30. 3% vs. 25. 6%, P <0. 05). The rs11466345G-allele carriers had a significantly increased risk of EH compared to rs11466345A -allele carrier ( OR = 1. 261 ; P <0. 05). The frequencies of genotypes and alleles of the other tSNPs of TGF-β_1 gene had no difference between EH patients and controls ( P > 0. 05 ). (2) Except the site of rs11466345, the other tSNPs were in strong LD, and no statistical differences were observed in haplotypes distribution in the followup study between case-control groups (P >0. 05). (3) There were no difference of TGF-β_1 levels between the different genotypes and alleles in tSNPs of TGF-β_1 gene ( P > 0. 05 ). Conclusions ( 1 ) These results suggested that TGF-β_1 gene rs11466345 G allele was likely to be a genetic susceptibility factor for EH in the Xinjiang Han population, the other tSNPs perhaps had no association with EH of in the study groups. (2) Except rs11466345, the other tSNPs were in strong LD, and the haplotypes reconsreucted by tSNPs might not be associated with EH in the Han nationality populations. (3) There was no association between the tSNP of TGF-β_1 gene and TGF-β_1 blood levels in the Xinjiang Han nationality population.     

急性低灌注脑梗死影像学特点与颅内动脉狭窄关系分析

目的：总结低灌注脑梗死影像学特点与颅内动脉狭窄关系。方法对52例低灌注脑梗死患者进行影像学特点总结,并对颈内动脉、大脑中动脉、椎基底动脉颅内段病变进行比较。结果（1）低灌注脑梗死病变影像学表现以分水岭脑梗死及多脑叶多发脑梗死为主要表现;（2）52例患者狭窄病变血管中颈内动脉14例,大脑中动脉18例,椎基底动脉7例,大脑前动脉或大脑后动脉狭窄共计7例,无血管病变6例。结论低灌注脑梗死影像学有其特殊性,病因与动脉血管狭窄密切相关。     

胱硫醚β-合成酶基因标签单核苷酸多态性与新疆哈萨克族原发性高血压的关联性

近年研究发现血浆HCY水平升高与EH有着密切的联系.CBS和MTHFR是HCY代谢过程中的2个关键酶,除营养因素外,CBS和MTHFR基因缺陷对血浆总HCY水平的影响[1]可间接导致EH,这已成为研究热点;而CBS作为HCY代谢途径中的关键酶之一,当其缺陷时可导致高同型半胱氨酸血症.目前,许多研究表明,CBS基因多态性与心脑血管疾病发生有关[2].目前,有关SNP与疾病的关联研究,除在SNP位点选择上注意了功能区(启动子和外显子)外,由于不同连锁标记间还存在LD.为增加基因分型的有效性,还需进行tSNP与疾病的关联性研究.     

偏头痛与癫关系的临床观察

目的探讨偏头痛与癫痫的关系。方法收集偏头痛患者及癫痫患者病史、临床表现、脑电图等资料,进行回顾性分析。结果偏头痛组患者及癫痫组患者经对照研究分析,相对危险度（RR）值均位于95％置信区间内。结论偏头痛与癫痫存在双向联系,偏头痛可能是癫痫的病因或危险因素,癫痫也可能引起偏头痛样发作。     

偏头痛与癫(癇)关系的临床观察

目的 探讨偏头痛与癫(癇)的关系.方法 收集偏头痛患者及癫(癇)患者病史、临床表现、脑电图等资料,进行回顾性分析.结果 偏头痛组患者及癫(癇)组患者经对照研究分析,相对危险度(RR)值均位于95%置信区间内.结论 偏头痛与癫(癇)存在双向联系,偏头痛可能是癫(癇)的病因或危险因素,癫(癇)也可能引起偏头痛样发作.