乙醇摄入对小鼠肝功能及磺胺嘧啶代谢动力学的影响

动态观察了乙醇摄入对小鼠肝功能及磺胺嘧啶（ＳＤ）代谢动力学的影响。结果表明，每天以２５ｇ／ｋｇ乙醇摄入２周，ＳＧＳＴ活性明显升高，随着摄入时间的延长，在一定时间范围内呈进行性增高，同时，ＳＡＬＴ活性也与乙醇摄入时间呈明显正相关，提示长期乙醇摄入对肝脏的不利影响。乙醇对肝匀浆中ＧＳＴ和苯胺羟化酶活性呈双重作用，早期具有诱导酶活性的作用，但诱导的时间和强度不同，后期则可抑制酶的活性。ＳＤ在小鼠体内的代谢符合二房室模型，乙醇对ＳＤ的代谢具有双相作用，早期使ＳＤ代谢加速，后期则使代谢延缓，表明乙醇对代谢ＳＤ的Ｎ乙酰化酶可能具有酶促酶抑双重作用。     

氧化锌软膏含量测定方法的改进

氧化锌软膏含量测定方法的改进汪佩（安徽省淮南市药品检验所２３２００７）氧化锌软膏为收敛药，用于治疗皮炎、湿疹等，疗效显著，是临床上常用药品。本品原料的含量测定《中国药典》（１９９０年版）采用络合量法。络合量法作为经典方法，结果可靠，终点明显。但对于...     

Design and application research of nucleotide sequence analysis system software

INTRODUCTION　　From integrallevel and celllevel,the research of organism and diseasediagnosishave already entered molecular level.Molecular biology is the science to researchstructure and function of organism macromolecule.Based on differentgene code se-…     

牛磺酸防止白内障形成的组织化学研究

目的：研究牛磺酸对晶体氧化损伤的保护作用。方法：将正常兔晶体分为正常条件培养组,Ｆｅｔｏｎ模型组（氧化损伤组）,氧化损伤同时给０．５％和１％牛磺酸保护组体外培养２４ｈ后,检测各组晶体的总抗氧化能力（Ｔ－ＡＯＣ）水平,可溶性蛋白含量,超氧化歧化酶（ＳＯＤ）,过氧化氢酶（ＣＡＴ）及谷胱苷肽过氧化物酶（ＧＳＨ－ＰＸ）活性蛋白含量以及脂质过氧化反应产物丙二醛（ＭＤＡ）含量。结果：和对照组比较,Ｆｅｔｏｎ模     

PBL联合学生讲课教学模式在麻醉科实习带教中的应用

目的 探讨以问题为基础的教学法（problem-based learning,PBL）联合学生讲课教学模式在麻醉科实习带教中的应用效果。方法 选择2021年12月至2023年12月在宁波市医疗中心李惠利医院麻醉科实习的46名麻醉专业本科学生为研究对象,按照随机数字表法将其分为传统组和联合组,每组各23名。传统组实习生采用传统教学模式,联合组实习生采用PBL联合学生讲课教学模式。实习结束后,比较两组实习生的出科考核成绩、带教效果及带教满意度。结果 联合组实习生的理论知识、专业技能、病例分析考核成绩均显著高于传统组（P<0.05）。联合组实习生的学习积极性、自主学习能力、问题分析能力、临床思维、创新能力评分及总分均显著高于传统组（P<0.05）。联合组实习生的带教满意度显著高于传统组（P<0.05）。结论 PBL联合学生讲课教学模式可激发麻醉科实习学生的学习热情,提高自主学习能力,显著提高麻醉科实习学生的综合成绩,且有利于培养学生的临床思维,提升教学满意度。     

Adhesive cryogel particles for bridging confined and irregular tissue defects

Background Reconstruction of damaged tissues requires both surface hemostasis and tissue bridging.Tissues with damage resulting from physical trauma or surgical treatments may have arbitrary surface topographies,making tissue bridging challenging.Methods This study proposes a tissue adhesive in the form of adhesive cryogel particles(ACPs) made from chitosan,acrylic acid,1-ethyl-3-(3-dimethylaminopropyl) carbodiimide(EDC) and N-hydroxysuccinimide(NHS).The adhesion performance was examined by the ...     

Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease

Parkinson’s disease(PD) is the most common neurodegenerative movement disease. It is featured by abnormal alphα-synuclein(α-syn) aggregation in dopaminergic neurons in the substantia nigra. Macroautophagy(autophagy) is an evolutionarily conserved cellular process for degradation of cellular contents, including protein aggregates, to maintain cellular homeostasis. Corynoxine B(Cory B), a natural alkaloid isolated from Uncaria rhynchophylla(Miq.) Jacks., has been reported to promote the clearance ...     

Relationship between glycemic variability and cognitive function in lacune patients with type 2 diabetes

BACKGROUND Lacunes are the manifestations of lacunar infarction which can lead many patients to the clinical outcome of disability or dementia. However, the relationship between lacune burden, cognitive function and blood glucose fluctuation in patients with type 2 diabetes mellitus(T2DM) complicated with lacunes is not very clear.AIM To explore the correlation between glucose variability, lacune burden and cognitive function in patients with lacunes complicated with T2DM.METHODS The clinical an...