Postconditioning’s Protection of THSG on Cardiac Ischemia-reperfusion Injury and Mechanism

Ischemic preconditioning or drug precondition-ing can markedly attenuate the myocardial ischemi-a-reperfusion injury.In recent years,Vinten-Jon-hansenet alreported the phenomenon of ischemiapostconditioning’s protection[1].The differencebetween theischemic pre-and post-preconditioningis that the former makes the myocardia transientischemia beforelong-termischemia to attenuate themyocardial injury following long-term ischemia-reperfusion,while thelatter means a methodto at-tenuate the reperfus…     

麝香祛痛气雾剂的抗炎镇痛作用与毒理学考察

目的:研究麝香祛痛气雾剂局部给药的抗炎镇痛作用及毒性反应。方法:用二甲苯致小鼠耳肿胀和角叉菜胶致大鼠足跖肿胀,考察麝香祛痛气雾剂的抗炎作用;用小鼠醋酸扭体法和热板法,观察麝香祛痛气雾剂的镇痛作用。观察家兔一次性局部给药的急性毒性和皮肤刺激性,观察豚鼠给药的皮肤致敏性。结果:麝香祛痛气雾剂局部皮肤给药,可明显减轻小鼠耳肿胀度,降低角叉菜胶致大鼠足跖肿胀;对小鼠醋酸扭体和热板反应均呈剂量相关性镇痛作用;对家兔和豚鼠无明显急性毒性反应、刺激性和致敏作用。结论:麝香祛痛气雾剂局部给药,具有明显的抗炎镇痛作用,无明显毒性、刺激性和致敏性。