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γ-去氢骆驼蓬碱等咔啉类生物碱的辐射防护作用 总被引:8,自引:0,他引:8
γ- Harmine(Ⅰ),’harmine(Ⅱ )and harmaline(Ⅲ )were isolated from PeganumHarmala L.( Zygophylaceae).Tests were conducted with mice to detect whether γ- harmine( a newcompound), harmine,harmof(Ⅳ)and harmalol(Ⅴ) are effective radioprotective compounds againstγ-ray irradiation, Intraperitoneal injection of the hydrochlorides of the four alkaloids 50~80mg·kg-1×1 in NIH male mice 30~45 minutes before 8.6~9. 7 Gy whole body 60Co irradiationsignificantly increased the survival effects(1. 33~2. 61)and 30-day survivai rate in comparison withcontrol mice.The results indicatethat γ- harmine exhibited relatively good radioprotective effect.γ-harmine is the first alkaloid isolated from a plant having ptotective effects against whole-body lethal irradiation in mice. 相似文献
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