米非司酮配合卡孕栓或米索前列醇抗初孕之早早孕64例临床效果分析

我们对临床应用的米非司酮配合米索前列醇或卡孕检抗初孕之早早孕64例进行分析，从而对口服药物抗早孕情况做进一步探讨。临床资料选择对象：（1）年龄在20－30岁之间，初孕要求终止妊娠自愿选择药物流产者；（2）无米非司团及卡孕检或米索前列醇使用禁忌症者，（3）从本次月经来潮第一天起，直到服用米非司酮时，闭经不超过49天；（4）临床检查确诊为妊娠，子宫大小与闭经天数相符。（5）未回眼避孕药及未带宫内节育器者。方法（1）对决定服药的患者讲情服药的注意事项，做好必要的用药前检查（如妇科检查、血尿常规等实验室检查）。（z）…     

外伤癃闭的可行疗法(摘要)

外伤癃闭的可行疗法（摘要）李芝芹（黑龙江省鹤岗市人民医院１５４１０１）ＡｐｌｉｋｅｂｌａＫｕｒａｃａｄｏｐｅｒＡｋｕｐｕｎｋｔｕｒｏｋａｊＭａｓａ＾ｇｏｐｒｉＵｒｉｎａＲｅｔｅｎｏＫａǔｚｉｔａｄｅＥｋｓｔｅｒａＶｕｎｄｏ（ＬｉＺｈｉｑｉｎ）据有关...     

慢性阻塞性肺疾病的护理

慢性阻塞性肺疾病是由慢性支气管炎、肺气肺引起的气流阻塞且呈进行性加重的一组慢性肺部疾病,其特点为慢性反复咳嗽、咳痰,呼吸困难呈进行性加重。常常并发肺心病和呼吸衰竭,影响生命质量。     

Observation on the therapeutic efficacy of acupuncture plus tuina for cervical vertigo

Objective

To observe the clinical efficacy and action mechanism of Jin’s three-needle acupuncture plus Long’s chiropractic tuina manipulations in treating cervical vertigo.

Methods

By adopting a randomized controlled method, 80 eligible patients were randomized into an observation group of 41 cases and a control group of 39 cases. The control group was intervened by Jin’s cervical three-needle acupuncture plus acupuncture at the vertigo-pain points and Fengchi (GB 20); the observation group was by Long’s chiropractic tuina manipulations in addition to the treatment given to the control. For both groups, the intervention was given once a day, 7 sessions as a treatment course, with a 1-day interval after a course, for 2 courses in total. The therapeutic efficacy was evaluated after the first session and the second treatment course, at the 3-month and 6-month follow-ups.

Results

After the first session, the recovery plus markedly effective rate of the observation group was significantly higher than that of the control group (P<0.01); the rate was markedly higher in the observation group than that in the control group after 2 treatment courses (P<0.01); at the 3-month follow-up, the relapse rate was 2.5% in the observation group versus 13.5% in the control, and the between-group difference was statistically insignificant (P>0.05); the 6-month follow-up study showed that the relapse rate was 5.0% in the observation group versus 21.6% in the control group, and the between-group difference was statistically significant (P<0.05); at the 6-month follow-up, the total relapse rate was 7.5% in the observation group versus 35.1% in the control group, and the inter-group difference was statistically significant (P<0.01).

Conclusion

The two treatment protocols are both effective in treating cervical vertigo. However, due to its more significant efficacy, more efficient action and lower relapse rate compared to acupuncture alone, acupuncture plus tuina can be regarded as a verified protocol for cervical vertigo.

     

支气管镜操作并发症的预防和处理

目的探讨纤维支气管镜(纤支镜)检查的并发症及护理对策。方法回顾分析300例纤支镜检查的并发症发生情况。结果术后咳血痰占首位,其次为术后咽喉不适、低氧血症、气管、支气管痉挛。结论充分的术前准备、熟练的操作技术、针对有可能出现的并发症给有效的防治、术中监测及护理、术后正确的护理是减少并发症发生的主要措施。     

人甲状旁腺激素(1-34)突变蛋白的设计与活性验证

通过对NCBI数据库中不同物种同源序列进行比对protein-protein BLAST,并利用计算机软件DiscoveryStudio3.1进行分子对接和分子动力学模拟,对天然人甲状旁腺激素(1 34)的3个氨基酸R25K26K27进行Q25E26L27置换,并对突变体的生物活性进行了评价。结果显示:突变后PTH(1 34)-(RKK-QEL)和突变前PTH(1 34)多肽主链叠合后均方根偏差RMSD值为2.509 3,说明两者主链结构构象差异不大;PTH(1 34)-(RKK-QEL)与受体蛋白PTH1R的相互作用能为599.253 kcal.mol 1,较天然PTH(1 34)的554.083 kcal.mol 1增强7.5%;氢键数目由32对增加至38对;PTH(1 34)-(RKK-QEL)能显著刺激UAMS-32P细胞RANKL基因的表达(P<0.01),并抑制OPG基因的表达(P<0.01);PTH(1 34)-(RKK-QEL)作用于UAMS-32P和小鼠原代股骨骨髓细胞共培养体系时,能显著刺激破骨细胞的形成(P<0.01),并且活性高于PTH(1 34)标准品。