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抗肿瘤药物研究Ⅰ:去甲斑蝥素氨基酸衍生物的合成与抗癌活性 总被引:1,自引:0,他引:1
In order to search for new compounds with higher anti-cancer activities and lower toxicities, 19 amino acid derivatives of norcantharidin, of which 16 are unknown compounds, were designed and synthesized. Preliminary screening results revealed that 2-(syn-exo-7-oxabicyclo [2. 2. 1] heptane-2, 3-dicarboxylic imido)-N-phenyl glutaramic acid exhibited a fairly apparent inhibitory activity against human-hepatoma cells in vitro (inhibitory rate 39.4% at 0.025 μtmol/ml). 相似文献
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为确保重组碱性成纤维细胞生长因子 (rbFGF)样品纯度大于 95 % ,本公司利用肝素凝胶与rbFGF的亲和力分离纯化rbFGF ,纯度可达到 95 %以上 ,但肝素凝胶亲和纯化bFGF ,使用次数应大于 2 0次 相似文献
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