抗肿瘤药物研究Ⅰ:去甲斑蝥素氨基酸衍生物的合成与抗癌活性

In order to search for new compounds with higher anti-cancer activities and lower toxicities, 19 amino acid derivatives of norcantharidin, of which 16 are unknown compounds, were designed and synthesized. Preliminary screening results revealed that 2-(syn-exo-7-oxabicyclo [2. 2. 1] heptane-2, 3-dicarboxylic imido)-N-phenyl glutaramic acid exhibited a fairly apparent inhibitory activity against human-hepatoma cells in vitro (inhibitory rate 39.4% at 0.025 μtmol/ml).     

肝素凝胶亲和纯化重组碱性成纤维细胞生长因子时凝胶使用次数研究

为确保重组碱性成纤维细胞生长因子 (rbFGF)样品纯度大于 95 % ,本公司利用肝素凝胶与rbFGF的亲和力分离纯化rbFGF ,纯度可达到 95 %以上 ,但肝素凝胶亲和纯化bFGF ,使用次数应大于 2 0次