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α-干扰素诱生过程中,诸多因素均可影响到干扰素的产量。我们对诱生条件中的关键因素白细胞分散度及pH进行了探讨。结果表明人血清能有效地分散白细胞,使干扰素效价明显高于对照组(P<0.05)。诱生过程中,定时调节与不调节pH对干扰素效价无明显影响(P>0.05)。 相似文献
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本文报告几年来从合成化合物中筛选抗肿瘤药的结果,在207种合成化合物中,有效药物主要都是氮芥衍生物,计有N-甲酰溶肉瘤素(M2),N-乙酰溶肉瘤素(M3),N-甲酰溶肉瘤素酰苯丙氨酸乙酯(M4),邻苯二甲谷氨酰溶肉瘤秦(M5)及α-硝基-β-双(2-氯乙基)氨基己酸乙酯(M9),α-硝基-β-双(2-氯乙基)氨基-β-(p-二甲苯基氨基)丙酸乙酯(M10)。在其他类型化合物中,只丙烷异硫脲酒石酸锑对吉田腹水肉瘤有一定疗效。有效化合物中以N-甲酰溶肉瘤素(M2),N-乙酰溶肉瘤素(M3),N-甲酰溶肉瘤素酰苯丙氨酸乙酯(M4)及邻苯二甲谷氨酰溶肉瘤素(M5)的疗效比较突出。已经在临床前药理研究的基础上,将N-甲酰溶肉瘤素及N-甲酰溶肉瘤素酰苯丙氨酸乙酯推荐给临床试用。 相似文献
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本文比较了我所合成的N-(4-乙氧羰基苯基)维生素甲酰胺(简称RI)及N-(4-羧酸苯基)维生素甲酰胺(简称RII)与维生素甲酸及其已知衍生物Ro10-9359、Ro 11-1430及Ro 4-3780的毒性。维生素甲酸、Ro10-9359及Ro11-1430可引起维生素甲过多症等毒性。Ro11-1430对精子有抑制作用。Ro4-3780对动物体重增长有影响。RII可导致肝组织损伤和脂肪变性,对精子亦有抑制作用。RI比维生素甲酸、Ro10-9359及Ro11-1430剂量高达4倍以上,比Ro4-3780剂量高33%,比RII剂量高1倍仍未见明显毒性。 相似文献
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Indigofera tinctoria L. (青黛) is effective against chronic granulocytic leukemia. Indirubin isolated from Indigofera tinctoria was found to be an active constituent. Be-cause of the meager content of indirubin and the increasing clinical demand for this compound, the study of synthetic indirubin was carried out in our institute. The anti-neoplastic action and toxicity of synthetic indirubin were studied in animals. Experim-ents showed that at therapeutic dosage synthetic indirubin yielded marked inhibition of Lewis lung carcinoma and Walker carcinosarcoma 256, but the inhibition on the gro-wth of L7212 leukemia and P388 leukemia in mice was not significant. Subacute toxicity tests showed that in rats given synthetic indirubin 100~400 mg/kg orally for 30 cons-ecutive days, no significant untoward effects on the number of leukocytes, liver (BSP retention) and renal (blood NPN) functions were observed. In dogs given synthetic indirubin, 20~40 mg/kg orally for 1 to 3 consecutive months, no significant abnormal-ity was observed. But in one dog synthetic indirubin induced severe anorexia and diar-rhea when the dosage was increased to 80 mg/kg/day. (Two weeks after withdrawal of the drug the GI reaction disappeared.) However, no bone marrow inhibition was obser-ved at the dosage of 40 mg/kg daily for 1 month and 80 mg/kg daily for 26 consecu-tive days. 相似文献
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