口腔念珠菌病患者唾液硝酸根分泌能力升高

Objective To observe the alterations of saliva nitrate and nitrite level in patients with oral candidiasis. Methods Parotid saliva and whole saliva were collected from 33 patients and 34 healthy volunteers. Concentrations of nitrate and nitrite in saliva were determined by high-performance liquid chromatography. Follow-up observation was performed on 10 patients after treatment. The data were statistically analyzed with independent-samples t test or paired-samples t test at α=0. 05. Results There was significant increase of the concentrations and secretion rate of parotid saliva nitrate in patient group as compared with controls: (49. 70±0. 50) vs (21.51±0. 60) mg/L (t=2. 692,P=0. 009) and (27.71±0. 50) vs (12. 55±0. 60)μg/min (t=2. 554, P=0. 013), respectively. Significantly increased concentrations and secretion rate of nitrate and nitrite [nitrate: (6. 46±0. 94) vs (1.11±0. 70) mg/L (t=3.792,P=0.000); nitrite: (8.48±0.58) vs (3.39±0.53) mg/L (t=2.888,P=0.005); nitrate secretion rate: (10. 57±0. 91) vs (2. 10±0. 74)μg/min (t=3.464, P=0. 001) ; nitrite secretion rate:(13.91±0.55) vs (6.42±0.58)μg,/min (t=2.397,P=0.020)]were revealed in whole saliva of patients group. Significantly decreased nitrate and nitrite levels were also observed in patients after treatment, especially the changes of parotid saliva nitrate secretion rate [(37. 50±0. 50) vs (14. 34±0. 64)μg/min (t=3. 142, P=0. 012)], whole saliva nitrate [(14.29±1.01) vs (2. 59±1.03) mg/L (t=3.475, P=0. 007)]and whole saliva nitrate secretion rate [(25.97±0. 93) vs (4. 12±1.00)μg/min (t=3. 922,P=0. 003)]. Conclusion The present study revealed the significant increase of salivary nitrate and nitrite level in patients with oral candidiasis is considered to be associated with the host defense reaction.     

近5年国家自然科学基金资助耳鼻咽喉科学研究结题分析及成果简介

This paper reviewed and analyzed the 72 fulfilled projects in the discipline of Otorhinolar-yngology supported in division Ⅱ of basic research of clinical medicine by the National Natural Science Foun-dation of China (NSFC) from year 2002 to 2006, and gave a brief introduction to the part of research a-chievements. The science foundation promotes Otorhinolaryngology to a quick development, and produces some outstanding research achievements with international recognition. Thus, it plays an important role in el-evating the level of discipline and bringing up specialists. According to the retrospection and analysis of the fulfilled projects and their research achievements, we hope it can objective and overall reflect research pro-gress in the field of Otorhinolaryngology, and offer as a reference to the relevant researchers and scientific re-search managers.     

近5年国家自然科学基金资助耳鼻咽喉科学研究结题分析及成果简介

This paper reviewed and analyzed the 72 fulfilled projects in the discipline of Otorhinolar-yngology supported in division Ⅱ of basic research of clinical medicine by the National Natural Science Foun-dation of China (NSFC) from year 2002 to 2006, and gave a brief introduction to the part of research a-chievements. The science foundation promotes Otorhinolaryngology to a quick development, and produces some outstanding research achievements with international recognition. Thus, it plays an important role in el-evating the level of discipline and bringing up specialists. According to the retrospection and analysis of the fulfilled projects and their research achievements, we hope it can objective and overall reflect research pro-gress in the field of Otorhinolaryngology, and offer as a reference to the relevant researchers and scientific re-search managers.     

近5年国家自然科学基金资助耳鼻咽喉科学研究结题分析及成果简介

This paper reviewed and analyzed the 72 fulfilled projects in the discipline of Otorhinolar-yngology supported in division Ⅱ of basic research of clinical medicine by the National Natural Science Foun-dation of China (NSFC) from year 2002 to 2006, and gave a brief introduction to the part of research a-chievements. The science foundation promotes Otorhinolaryngology to a quick development, and produces some outstanding research achievements with international recognition. Thus, it plays an important role in el-evating the level of discipline and bringing up specialists. According to the retrospection and analysis of the fulfilled projects and their research achievements, we hope it can objective and overall reflect research pro-gress in the field of Otorhinolaryngology, and offer as a reference to the relevant researchers and scientific re-search managers.     

近5年国家自然科学基金资助耳鼻咽喉科学研究结题分析及成果简介

This paper reviewed and analyzed the 72 fulfilled projects in the discipline of Otorhinolar-yngology supported in division Ⅱ of basic research of clinical medicine by the National Natural Science Foun-dation of China (NSFC) from year 2002 to 2006, and gave a brief introduction to the part of research a-chievements. The science foundation promotes Otorhinolaryngology to a quick development, and produces some outstanding research achievements with international recognition. Thus, it plays an important role in el-evating the level of discipline and bringing up specialists. According to the retrospection and analysis of the fulfilled projects and their research achievements, we hope it can objective and overall reflect research pro-gress in the field of Otorhinolaryngology, and offer as a reference to the relevant researchers and scientific re-search managers.     

顽固性剥脱性唇炎—附1例报告及文献回顾

剥脱性唇炎(Exfoliative cheilitis)为少见的累及唇红粘膜以脱屑、结痂为主要病损的慢性唇炎.该病以青年女性多见,近年来作者收治一名青年男性,患有反复发作较顽固的剥脱性唇炎,现报告如下.     

警惕:美国猴痘疫情紧急警报

为指导“猴痘”的临床诊治,美国CDC立即制定了诊断试行标准。最新研究发现接触传染源后2周内、尤其是最初4天接种天花疫苗有效,有效率85％,抗病毒药物Cidofovir也正在试用中。文详见第9版《资讯·第一视点》。     

唾液血型物质分泌类型与抗念珠菌IgA荧光抗体关系的研究

本研究对２６例口腔念珠菌患者非刺激性混合唾液进行了抗念珠菌荧光ＩｇＡ抗体及血型物质分泌型的测定，结果为唾液血型物质分泌型２４例（９２．３％），非分泌型２例（７．７％）。分泌型者血型为Ａ型６例，Ｂ型１０例，ＡＢ型２例及Ｏ型６例。唾液血型物质分泌型者与非分泌型者的唾液抗念珠菌光抗体阳性数无显著性差别（Ｐ＝０．７７８），唾液血型物质非分泌型者也可检测到唾液抗念念珠菌ＩｇＡ抗体，本文结果表明唾液抗念珠菌荧     

近25年国家自然科学基金资助内分泌代谢领域基础研究的回顾分析

目的 分析自国家自然科学基金委员会(NSFC)成立以来,资助内分泌代谢领域基础研究对该学科发展的作用.方法 收集1987年至2010年NSFC对内分泌代谢领域的资助项目数量、经费、单位分布、连续资助及获得多次资助情况,对近两年已结题项目的完成情况及资助的研究方向进行分析.结果 1987至2010年共资助内分泌代谢领域研究项目731项,资助总金额为1.78亿元,其中面上项目462项,青年科学基金项目187项,地区基金28项,重点项目9项,国家杰出青年基金项目5项,海外学者合作研究基金2项,创新研究群体项目1项,国际合作项目11项,其他项目26项.对2009年至2010年内分泌代谢领域结题的102项资助项目进行的初步分析表明,结题时在SCI收录杂志上发表论文279篇(平均每项2.74篇),在国内核心期刊发表论文236篇(平均每项2.3篇),培养博士后8名,博士研究生169名,硕士研究生227名.结论近25年来,NSFC对内分泌代谢领域的资助呈持续、稳定增长的态势,尤其是研究类、人才类项目增加较多,获得资助的单位数量逐年增多,取得了较好的研究成果,促进了内分泌代谢领域的基础研究、人才培养和学科发展.     

口腔念珠菌带菌与感染状态分离菌株的RAPD分析

目的 :研究念珠菌种之间及不同来源白念珠菌菌株之间的基因型相关性。方法 :对口腔白念珠菌病原菌、共生菌及非白念病原菌分别进行表型和RAPD分析。结果 :白念珠菌与非白念珠菌的RAPD带型存在差异 ,相似系数在 5 1.7%。共生菌与病原菌RAPD带型未见差异。白念珠菌种内相似系数大于 70 % ,菌株间存在DNA多态性。结论 :共生白念珠菌与病原菌未见RAPD带型差别 ,提示对口腔念珠菌病的防治应重视宿主因素在发病中的作用。