正常人24小时尿钙测定

正常成人体内钙总量约1000～1200g,99%存在于骨髂和牙齿中,细胞外液和软组织含钙总最仅占1%。正常情况下,血浆含钙总量约为300～350mg,平均8～10mg/dl。每日排泄的钙大约20%由尿排出,80%由粪便排出,汗液中也含一定量的钙,但汗液的多少随气温不同变化很大,难以精确     

实验性氟中毒大鼠骨密度和尿钙、磷以及羟脯氨酸的改变

氟中毒以骨骼受累为甚,亦称氟骨症,临床上有骨硬化、骨软化和骨质疏松等表现,从而能在 X 线检查和骨密度测定两方面找到诊断的依据。流行病学的调查表明,在临床症状出现之前,即可发生生物化学的改     

BONE DYNAMIC CHANGES IN EXPERIMENTAL FLUOROSIS OF RATS

Fifteen hybrid rats divided int0 3 groups (A, B and C) were fed for 250 days with distilled, 50 ppm and 80 ppm NaF water respectively. Before exsanguination, doubled tetracycline labelings were made on all of the experimental animals for bone dynamic study. The available data suggest that the primary mineralization and matrix synthesis in group B and C were significantly inhibited, indicating the toxic effects of high fluoride on osteoblasts. For a better understanding of the pathogenesis of osteos clerosis, osteomalacia and osteoporosis in endemic fluorosis, we wou.lld suggest that fluoride be used not only as a stimulator for bone formation as is being recommended in the treatment of postmeno pausal ostcoporosis accompanied somewhat by osteosclerosis, but also as an inhibitor for matrix synthesis and primary mineralization through its toxic effects on osteoblast. We believe that the pathology of fluorosis depends largely on the dose of fluoride intake.