序贯疗法治疗十二指肠球部溃疡幽门螺杆菌感染的临床研究

目的观察序贯疗法治疗十二指肠球部溃疡（DU）并幽门螺杆菌（Hp）感染的疗效。方法选择前313内经内镜检查证实为活动性DU,溃疡长径超过3ram;“碳-尿素呼气试验（14C—UBT）确诊Hp（＋）的60例患者,按随机分为两组,传统三联疗法组：奥美拉唑20rag,1日2次,疗程4周,前10天加服克拉霉素0．5g,1日2次,阿莫西林1g,1日2次;序贯疗法组：奥美拉唑20mg,1132次,疗程4周,前5天加用阿莫西林1g,1132次,第6～10天加用克拉霉素0．5g,1日2次,甲硝唑0．4g,1日2次。结果传统三联疗法组溃疡愈合率80％,Hp根除率77％;序贯疗法组溃疡愈合率90％,Hp根除率97％。结论序贯疗法具有溃疡愈合率及Hp根除率高的优点。可作为DU并Hp感染的一线治疗方案。     

序贯疗法治疗十二指肠球部溃疡幽门螺杆菌感染的临床研究

Objective To observe the curative effect of the sequential therapy in the treatment for the duodenobnlbar ulcer with Helicobacter pylori(Hp) infection.Methods 60 activity duodenobulbar ulcer (deer size ≥ 0.3cm in diameter) proved by endosoopy patients with Hp positive who were detected by 14C urea breath test were randomly divided into two groups. Both of these groups were treated with 4-week therapy: Omeprazole(20 mg twice daily) together with either Amoxicillin (0.5g twice daily) and Clarithromyein (1 g twice daily) for the first 10 days (the traditionahriple group) or Amoxicillin(1g twice daily) for the first 5 days, then Clarithromycin (0.5g twice daily) and Metronidazole (0.4g twice daily) at the second five days (the sequential group).Results The ulcer healing rates in the traditional triplegroup and the sequential group were 80% and 90%.The eradication rate of the traditional triple group was77% and that of sequential therapy was 97%.Conclusions Sequential therapy is more effective in ulcer healing and Hp eradication.