鼻腔鼻窦恶性纤维组织细胞瘤1例报告

患者男,33岁。头痛及鼻出血1个月。头痛以前额较重,夜间明显,不能入眠。右面部及牙龈麻木,右耳阵发性疼痛,右侧眼球突出,眼睑肿胀,复视,睁眼受限。体检:外鼻无畸形,鼻窦区无压痛,鼻黏膜轻度充血,双侧下鼻甲稍肥大。鼻内镜:右侧鼻腔有坏死出血组织,去除坏死组织,见暗红色新生物来自嗅裂,鼻咽大部也有新生物充填。胸部X线检查及心电图无异常,化验检查无异常。影像学检查:(1)CT检查,轴位及冠状位平扫,右侧鼻腔上部软组织密度肿物,CT值49HU,较均匀,向上及向前侵犯同侧后组筛窦、右侧眶尖、蝶窦,蝶骨体及右侧蝶骨大、小翼内侧部分骨质破坏(图1…     

鳞状细胞癌抗原在肺癌诊断和预后方面的意义

在过去几年中,已发现许多具有潜在使用价值的肿瘤标记。就肺癌而言,小细胞肺癌有数种敏感性和特异性都较好的标记,如神经元特异性烯醇化酶、B-B肌酸激酶等。但对非小细胞肺癌,已知的标记物(主要是癌胚抗原,CEA)不够敏感。特异性亦差。最近,一些作者研究了鳞状细胞癌抗原(SCCAg)在肺癌诊断及临床     

脑星形细胞瘤中TIP30、VEGF和CD34的表达及其相关性研究

Objective To investigate the expression and relationship of TIP30(HIV-1 Tat interactive protein 2), vascular endothelial growth factor (VEGF) and MVD (detected by CD34) in the angiogenesis of human brain astrocytomas. Methods Expression of TIP30, VEGF and CD34 in 19 cases of normal brain tissue and 71 cases of astrocytoma were immunohistochemically examined with Elivision plus two-step method. Results The positive expression of TIP30 could be seen in cytoplasm of neuroglial cells and neurons of 19 normal brain tissues. The positive expression rate of TIP30 in 71 cases of astrocytoma was 33.80 % (24/ 71). The positive expression rate of TIP30 in astrocytoma of different grades was 52 % for grade Ⅱ, 34.78 % for grade Ⅲ and 13.04 % for grade Ⅳ. The positive expression rate of TIP30 in high grade (Ⅲ+Ⅳ) of astrocytoma was found significantly lower than that in low grade(Ⅱ) (χ2=5.71, P <0.05); The expression of VEGF and MVD detected by CD34 in astrocytomas were higher than that in normal brain tissue and increased as the tumor grade increased; In astrocytoma, the negtive correlation was found between the expression of TIP30 and VEGF (r=-0.428, P<0.05); no correlation was found between TIP30 and MVD(r=-0.065, P 0.05); the positive correlation was found between VEGF and MVD(r=0.684, P<0.01). Conclusion The positive expression rate of TIP30 in normal brain tissue is significantly higher than that in astrocytoma. The positive expression rate of TIP30 significantly decreases as the pathological grade of the astrocytoma increases; The expression of TIP30 and VEGF is negatively correlated in astrocytoma.     

脑星形细胞瘤中TIP30、VEGF和CD34的表达及其相关性研究

Objective To investigate the expression and relationship of TIP30(HIV-1 Tat interactive protein 2), vascular endothelial growth factor (VEGF) and MVD (detected by CD34) in the angiogenesis of human brain astrocytomas. Methods Expression of TIP30, VEGF and CD34 in 19 cases of normal brain tissue and 71 cases of astrocytoma were immunohistochemically examined with Elivision plus two-step method. Results The positive expression of TIP30 could be seen in cytoplasm of neuroglial cells and neurons of 19 normal brain tissues. The positive expression rate of TIP30 in 71 cases of astrocytoma was 33.80 % (24/ 71). The positive expression rate of TIP30 in astrocytoma of different grades was 52 % for grade Ⅱ, 34.78 % for grade Ⅲ and 13.04 % for grade Ⅳ. The positive expression rate of TIP30 in high grade (Ⅲ+Ⅳ) of astrocytoma was found significantly lower than that in low grade(Ⅱ) (χ2=5.71, P <0.05); The expression of VEGF and MVD detected by CD34 in astrocytomas were higher than that in normal brain tissue and increased as the tumor grade increased; In astrocytoma, the negtive correlation was found between the expression of TIP30 and VEGF (r=-0.428, P<0.05); no correlation was found between TIP30 and MVD(r=-0.065, P 0.05); the positive correlation was found between VEGF and MVD(r=0.684, P<0.01). Conclusion The positive expression rate of TIP30 in normal brain tissue is significantly higher than that in astrocytoma. The positive expression rate of TIP30 significantly decreases as the pathological grade of the astrocytoma increases; The expression of TIP30 and VEGF is negatively correlated in astrocytoma.     

Artemin在食管癌中表达作用的研究﹡

目的：探讨 Artemin（ATRN）在食管癌中的表达及作用。方法： 采用免疫组化和 real-time PCR 方法检测ATRN 在食管癌组织 126 例、癌旁组织 126 例和正常组织 21 例中的表达水平;应用 siRNA 技术在食管癌 TE11 细胞系中研究ATRN 表达及对肿瘤细胞的凋亡影响。结果： 126 例食管癌中ATRN 的阳性表达率为73.81% （93/126） ,癌旁组织的阳性表达率为44.44% （56/126） ; 21 例正常食管组织中的ATRN 阳性表达率为14.29% （3/21）,正常食管组织与食管癌组织及癌旁组织比较差异均有统计学意义 （字2分别为 32.89、 23.15, 均 P 约 0.01） ; TE11-siRNA 细胞系 ATRN 的mRNA 和蛋白表达水平均低于 TE11-CK细胞系中相应的表达水平。siRNA 抑制食管癌细胞中 ATRN 的表达后, 促进了 TE11 细胞的凋亡。结论： ATRN 与食管癌的生物学行为有关。     

多中心性肠系膜纤维瘤病临床病理分析(附1例报告)

肠系膜纤维瘤病(mesenteric fibromatosis,MF),也称为韧带样型纤维瘤病,是发生在肠系膜的腹腔内纤维瘤的一个非常少见的亚型,以浸润性生长和易于局部复发为特征,但不转移[1]。本文诊断多中心性肠系膜纤维瘤病1例,并复习文献报告如下。患者,女性,38岁。因腹腔肿物11d,在当地医院     

Stat3通路相关基因在散发性大肠管状腺瘤癌变中的表达及意义

目的 探讨Stat3及CyclinD1、Bcl-xL在散发性大肠管状腺瘤癌变过程中的可能作用。方法 采用免疫组化方法检测107例散发性大肠管状腺瘤异型增生及癌变组织中Stat3和CyclinD1、Bcl-xL在蛋白水平的表达情况。结果 腺瘤伴异型增生组和癌变组中的Stat3蛋白的表达明显高于正常大肠黏膜组(P=0.000),且癌变组中Stat3蛋白的表达高于腺瘤伴异型增生组(P=0.003);腺瘤伴异型增生组和癌变组中CyclinD1蛋白的表达均明显高于正常大肠黏膜组(P=0.000),且癌变组中CyclinD1蛋白的表达高于腺瘤伴异型增生组(P=0.000);大肠管状腺瘤伴异型增生组和癌变组中Bcl-xL在蛋白水平的阳性表达率均明显高于正常大肠黏膜组（P=0.000),而且癌变组中Bcl-xL的表达明显高于腺瘤伴异型增生组(P=0.000);Stat3、CyclinD1和Bcl-xL均随腺瘤异型增生程度的增高呈递增趋势。Stat3与CyclinD1、Bcl-xL 的表达存在正相关关系。结论 Stat3、CyclinD1和Bcl-xL可能在散发性大肠管状腺瘤癌变过程中起一定的作用。     

脑星形细胞瘤中TIP30、VEGF和CD34的表达及其相关性研究

Objective To investigate the expression and relationship of TIP30(HIV-1 Tat interactive protein 2), vascular endothelial growth factor (VEGF) and MVD (detected by CD34) in the angiogenesis of human brain astrocytomas. Methods Expression of TIP30, VEGF and CD34 in 19 cases of normal brain tissue and 71 cases of astrocytoma were immunohistochemically examined with Elivision plus two-step method. Results The positive expression of TIP30 could be seen in cytoplasm of neuroglial cells and neurons of 19 normal brain tissues. The positive expression rate of TIP30 in 71 cases of astrocytoma was 33.80 % (24/ 71). The positive expression rate of TIP30 in astrocytoma of different grades was 52 % for grade Ⅱ, 34.78 % for grade Ⅲ and 13.04 % for grade Ⅳ. The positive expression rate of TIP30 in high grade (Ⅲ+Ⅳ) of astrocytoma was found significantly lower than that in low grade(Ⅱ) (χ2=5.71, P <0.05); The expression of VEGF and MVD detected by CD34 in astrocytomas were higher than that in normal brain tissue and increased as the tumor grade increased; In astrocytoma, the negtive correlation was found between the expression of TIP30 and VEGF (r=-0.428, P<0.05); no correlation was found between TIP30 and MVD(r=-0.065, P 0.05); the positive correlation was found between VEGF and MVD(r=0.684, P<0.01). Conclusion The positive expression rate of TIP30 in normal brain tissue is significantly higher than that in astrocytoma. The positive expression rate of TIP30 significantly decreases as the pathological grade of the astrocytoma increases; The expression of TIP30 and VEGF is negatively correlated in astrocytoma.     

原发性阑尾腺癌1例并文献复习

患者,女性,35岁.右下腹疼痛4个月加重10d急诊入院.查体,腹软,右下腹局限性压痛、反跳痛,并可触及6.0cm×5.0cm×2.0cm包块.B超示,阑尾周围脓肿.实验室检查,白细胞11.0×109/L.临床诊断:阑尾周围脓肿.术中探察,大网膜与回盲部紧密包裹,阑尾为盲肠后外侧位,明显增粗,无坏死穿孔,纵行剖开阑尾,可见腔内有一乳头状肿物阻塞管腔,术中冰冻病理回报,阑尾腺癌.行右半结肠切除术.     

重症肌无力患者胸腺CT与病理学检查结果对照

本研究对2000～2003年在我院行胸腺切除手术治疗的29例重症肌无力(MG)患者的胸腺CT与胸腺病理学检查结果进行对比分析,探讨胸腺CT对胸腺病变的诊断价值. 1 临床资料 1.1 一般资料本组男13例,女16例;年龄2～67岁,平均29.8岁;病程10 d～5年,平均9个月.