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作者观察单剂量及长期灌饲卡托普利对卒中易感型自发性高血压大鼠(stroke-prone sponta-neously hypertensive rat,SHRsp)的作用。发现它可抑制其高血压的自发形成,明显降低血清血管紧张素转化酶(serum angiotensin convertingenzyme,SACE)活性水平,减少血浆血管紧张素Ⅱ(angiotensinⅠ,AⅠ)浓度,反馈性增加血浆肾素活性(plasma tenin activity,PRA)。提示肾素血管紧张素系统(renin-angiotensin system,RAS)可能在这类大鼠的高血压发生和维持上起一定作用。 相似文献
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钙内流阻滞剂(Calcium Entry Blocker,CEB)是一组不同结构的药物,其唯一共同的特性是选择性地抑制钙的跨膜内流。近年来在高血压治疗中的地位日趋重要,本文重点介绍其作用机制和治疗效果的研究近况。 相似文献
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α-Human atrial natriuretic polypeptide (α-hANP) was applied to 16 clinical patients, 6 patints with essential hypertension, 7 patients with congestive heart failure and 3 patients with cirrhosis. Following intravenous bolus injection of 400 μg of synthetic α-hANP, a hypotensive effect of very rapid onset was found, which was more potent in the hypertensive patients than in the normotensive cases. Cardiac functions were improved significantly in a similar time course as the depressor response in the cases of heart failure or hypertension. Hemodynamic observations showed a marked increase in cardiac output, cardiac index, stroke volume, ejection fraction and ejection rate, and a concomitant decrease of the pressure in the right side of the heart and pulmonary circulation in these subjects. In addition, the renal response to α-hANP induced obvious increases in urine volume, electrolytes and creatinine excretions in all the subjects. Finally, plasma levels of aldosterone, Arg-vasopressin and noradrenal 相似文献
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