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目的观察加味温胆汤治疗脑卒中后抑郁焦虑共病(PSCAD)的临床疗效。方法将80名患者随机分组,分为中药组(40例)和对照组(40例)。对照组口服盐酸帕罗西汀片20 mg/d,中药组加服加味温胆汤,一日2次。共治疗6周。治疗前后对2组患者用汉密尔顿抑郁量表(HAMD)24项版、汉密尔顿焦虑量表(HAMA)量表、血清BDNF水平、临床疗效评定,以不良反应量表(TESS)评估安全性。结果治疗2周后,中药组HAMD评分低于对照组(P0.05),治疗4周后,中药组HAMA评分低于对照组(P0.05);治疗6周后,患者血清BDNF水平均较治疗前升高(P0.05),中药组高于对照组(P0.05)。治疗6周后,中药组有效率(80.0%)高于对照组(62.53%)(P0.05);两组均未出现严重不良反应,中药组与对照组比较,失眠、肌强直、震颤、食欲减退等不良反应少(P0.05)。结论加味温胆汤治疗脑卒中后抑郁焦虑共病是一种安全有效的疗法。 相似文献
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目的:观察天麻钩藤饮加味治疗肝阳上亢型偏头痛的临床疗效.方法:将符合诊断标准的60例患者随机分为两组各30例.治疗组予天麻钩藤饮加味治疗,对照组予盐酸氟桂利嗪胶囊治疗,15天为1个疗程,共治疗2个疗程,观察两组头痛次数、临床症状的变化.结果:治疗组总有效率为90.00%,对照组为66.67%,两组比较差异有统计学意义(... 相似文献
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目的:系统评价中药复方联合多奈哌齐治疗血管性痴呆(VaD)的临床疗效。方法:检索万方、中国知网、中国生物医学文献、the Cochrane Library等数据库,收集公开发表的中药复方治疗VaD的随机对照临床试验,时间范围均为建库至2022年10月。将收集到的研究进行Meta分析以及试验序贯分析。结果:共计纳入14项研究,总样本量1 103例。与单纯使用多奈哌齐对比,中药复方联合多奈哌齐治疗VaD能提高简易精神状态(MMSE)评分[MD=2.44,95%CI=(1.48,3.40),P<0.000 01]和日常生活能力量表(ADL)评分[MD=5.08,95%CI=(1.43,8.73),P=0.006],降低肿瘤坏死因子α(TNF-α)水平[MD=-23.38,95%CI=(-28.51,-18.25),P<0.000 01]、白细胞介素6(IL-6)水平[MD=-6.59,95%CI=(-12.97,-0.21),P=0.04]和C反应蛋白(CRP)水平[MD=-1.90,95%CI=(-3.31,-0.49),P=0.008]。试验序贯分析显示,主要疗效指标MMSE... 相似文献
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王净净教授临证常用药对举隅 总被引:1,自引:0,他引:1
王净净教授系湖南中医药大学博士生导师,曾任湖南省第二批老中医药专家学术经验继承工作指导老师,现任全国第五批老中医药专家学术经验继承工作指导老师、湖南省中西医结合学会常务理事.王老师从事教学、科研与临床近四十年,临床上擅长诊治中医脑病及内科疑难杂病,如,中风、痹证、眩晕、头痛、癫痫以及情志不遂引起的失眠、郁证等疾病,并且在用药方面善于运用中药药对,加减灵活,疗效确切. 相似文献
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目的:探讨血塞泰治疗急性脑梗死风痰瘀阻证患者的临床疗效及作用机理。方法:将符合纳入标准的急性脑梗死患者60例,随机分为两组,每组30例。对照组给予常规西药治疗,治疗组在对照组治疗的基础上加血塞泰,4 w为1个疗程。观察治疗前后两组病例中医证候积分、神经功能缺损评分、hs-CRP水平的变化。结果:两组病例治疗后中医证候积分、神经功能缺损评分、hs-CRP水平均较本组治疗前降低(P<0.01),且治疗组治疗后上述指标低于对照组(P<0.05)。结论:血塞泰对脑梗死风痰瘀阻证临床疗效肯定,可改善症状、体征;其机制可能与降低hs-CRP水平有关。 相似文献
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Objective
To observe the therapeutic efficacy of acupuncture plus Tai Ji Quan (Tai Chi) in recovering the neurological function and treating depression state in post-stroke depression patients, together with a 12-month follow-up.Methods
A total of 105 eligible post-stroke depression patients were randomized into an acupuncture plus Tai Ji group (53 cases) and a control group (52 cases) based on their visiting sequence. The patients all received routine treatment and rehabilitation training for stroke. In addition, the control group was given oral administration of citalopram hydrobromide tablets, 1 month as a course of treatment, for 3 courses in total. Meanwhile, the acupuncture plus Tai Ji group received acupuncture and practiced Tai Ji Quan, for 1 month and 12 months respectively. Before the intervention, after 1-month intervention and 12 months later, the National Institute of Health stroke scale (NIHSS), Barthel index (BI) and Hamilton depression rating scale (HAMD) were adopted for efficacy evaluation.Results
Prior to the intervention, there were no significant differences in HAMD, NIHSS and BI scores between the two groups (all P>0.05); after 1-month intervention, there were significant between-group differences in NIHSS, BI and HAMD scores (P<0.05 or P<0.01); the 12-month follow-up revealed significant between-group differences in NIHSS, BI and HAMD scores (all P<0.01). In the treatment of stroke, the total effective rate was 84.4% in the acupuncture plus Tai Ji group, significantly higher than 68.9% in the control group (P<0.05); in the treatment of depression, the total effective rate was 86.7% in the acupuncture plus Tai Ji group, significantly higher than 77.8% in the control group (P<0.05).Conclusion
Acupuncture plus Tai Ji Quan can produce a significant efficacy in improving the limb motor function and depression in post-stroke depression patients.10.
目的:探讨炎性细胞因子系统对心肌梗死后心室重构的影响及益心泰丸对心室重构干预作用。方法:制备心肌梗死大鼠模型。随机分成模型组、益心泰组开博通组、复方丹参滴丸组和假手术组。除模型组和假手术组以蒸馏水等量灌胃,其余各组分别给予相应药物灌胃,用药4周后分别检测心室重构指标及血浆中TNF-α、IL-6含量。结果:与假手术组比较,模型组心脏重量、心脏指数增加(P<0.01);与模型组比较,益心泰组、复方丹参滴丸组和开博通组心脏重量、心脏指数降低(P<0.01)。与假手术组比较,模型组血浆中TNF-α、IL-6含量明显升高(P<0.01),与模型组比较,益心泰组、复方丹参滴丸组和开博通组TNF-α、IL-6含量均有下降(P<0.01)。而益心泰组、复方丹参滴丸组和开博通组心脏指数、TNF-α、IL-6差异无统计学意义(P>0.05)。结论:益心泰丸可能通过调节炎性细胞因子水平,在一定程度上干预了心肌梗死后心室重构。 相似文献