Release Rate of Megestrol Acetate from Sillicon Rubber Vaginal Rings in vitro

A methods for the release rate measurement of megestrol acetate from vaginal rings is described. The contraceptive vaginal rings were bathed in 1:750 benzalkonium ehtoride aqueous solution in wide-necked bottles kept in shaking water bath. The temperature was maintained at 37℃ and the solution was changed daily. Megestrol acetate was assayed by measuring the ultraviolet absorption of the solution at 290nm. The release curve of megestrot acetate in vitro was found to be flat, except a burst of release was present in the first 7 days.     

甲地孕酮阴道避孕药环体外释放量测试研究

本文研究了甲地孕酮避孕药环体外释放,以带磨口的广口瓶作释放池,内放一定体积的1:750氯化[烃基二甲基代苯甲]铵水溶液作为释放介质。甲地孕酮硅橡胶环浸在介质中,在37℃恒温条件下,以一定的频率和振幅振荡,每隔24小时调换介质溶液。用紫外分光光度法,在波长290nm 处测定释放液中甲地孕酮的含量。实验结果表明,甲地孕酮经最初七天的快速释放后,达到稳态释放。     

中国乌头之研究 ⅩⅨ 四川雪上一枝蒿中生物碱及其结构

从四川金沙江畔雪上一枝蒿(Aconitum pendulum)中分出四个结晶性的生物碱,证明其中三个为已知生物碱,即次乌头碱(hypaconitine),乌头碱(aconitine)和3-乙酰乌头碱(3-acetylaconitine);另一种为新生物碱,暂称为雪乌碱(penduline)熔点166～167℃,分子式C₃₄H₄₇NO₉,结构式初步推定如下式所示。雪上一枝蒿中主要生物碱为乌头碱,得率约为0.14%;雪乌碱对动物具有镇痛局麻等作用。     

芹菜中的新香豆素:Celerin

从芹菜(Apium graveolens)种子中获得一个新香豆素命名为celerin,另分离得2种已知香豆素osth-enol,apigranin和对羟基肉桂酸。方法:干燥的芹菜种子,用石油醚,苯和乙醚连续提取,浓缩石油醚部分,经硅胶层析,以石油醚→苯梯度洗脱,先下来的部分有6个香豆素,再用制备性薄层层析(硅胶,丙酮-苯1:4)。从苯洗脱的部分,在稀甲醇中     

中国乌头的研究——ⅩⅦ.伏毛铁棒锤Aconitum flavum Hand-Mazz中生物碱

伏毛铁棒锤Aconitum flavum Hand-Mazz系我国西北地区民间常用草药,块根为活血为瘀,祛风湿,止痛止血药,其总生物碱部分临床用于多种疾病的疼痛有较好疗效。从中分得二个主要生物碱,鉴定为3-乙酰乌头碱(3-acetylaconitine,Ⅰ)和乌头碱(aconitine,Ⅱ),前者从植物中首次分得,对动物的心脏毒性和急性毒性比乌头碱小,用热板法试验表明,给小白鼠皮下注射3-乙酰乌头碱0.1～0.2mg/kg,有明显的镇痛作用,注射于小     

中国乌头的研究——ⅩⅦ.伏毛铁棒锤Aconitum flavum Hand-Mazz中生物碱

From a Chinese herb Fu Mao Tie Bang Ghui, the root of Aconitum flavum Hand-Mazz, collected from Ning Xia Autonomous Region, two alkaloids Ⅰ and Ⅱ have been isolated. On the basis of spectroscopic analyses and chemical methods, Ⅰ and Ⅱ were identified as 3-acetylaconitine and aconitine respectively.3-acetylaconitine, C₃₆ H₄₉ O₁₂ N, mp. 196-197℃, [α]_D²⁴+18.6° (C. 1.0, CHCl₃) was discovered in nature for the first time.