全文获取类型
收费全文 | 2104篇 |
免费 | 79篇 |
国内免费 | 77篇 |
专业分类
耳鼻咽喉 | 53篇 |
儿科学 | 97篇 |
妇产科学 | 72篇 |
基础医学 | 200篇 |
口腔科学 | 41篇 |
临床医学 | 187篇 |
内科学 | 442篇 |
皮肤病学 | 65篇 |
神经病学 | 127篇 |
特种医学 | 288篇 |
外科学 | 144篇 |
综合类 | 29篇 |
预防医学 | 111篇 |
眼科学 | 73篇 |
药学 | 254篇 |
中国医学 | 8篇 |
肿瘤学 | 69篇 |
出版年
2023年 | 12篇 |
2022年 | 16篇 |
2021年 | 15篇 |
2020年 | 18篇 |
2019年 | 51篇 |
2018年 | 68篇 |
2017年 | 41篇 |
2016年 | 50篇 |
2015年 | 40篇 |
2014年 | 76篇 |
2013年 | 89篇 |
2012年 | 87篇 |
2011年 | 108篇 |
2010年 | 99篇 |
2009年 | 75篇 |
2008年 | 66篇 |
2007年 | 93篇 |
2006年 | 55篇 |
2005年 | 49篇 |
2004年 | 52篇 |
2003年 | 74篇 |
2002年 | 59篇 |
2001年 | 47篇 |
2000年 | 35篇 |
1999年 | 10篇 |
1998年 | 84篇 |
1997年 | 74篇 |
1996年 | 62篇 |
1995年 | 54篇 |
1994年 | 44篇 |
1993年 | 44篇 |
1992年 | 22篇 |
1991年 | 15篇 |
1990年 | 22篇 |
1989年 | 37篇 |
1988年 | 38篇 |
1987年 | 27篇 |
1986年 | 26篇 |
1985年 | 23篇 |
1984年 | 21篇 |
1983年 | 13篇 |
1982年 | 18篇 |
1981年 | 11篇 |
1980年 | 16篇 |
1978年 | 9篇 |
1977年 | 17篇 |
1976年 | 14篇 |
1975年 | 16篇 |
1955年 | 29篇 |
1954年 | 99篇 |
排序方式: 共有2260条查询结果,搜索用时 15 毫秒
1.
2.
3.
P Avalos-Peralta† A Herrera† JJ Ríos-Martín‡ AM Pérez-Bernal† D Moreno-Ramírez† F Camacho† 《Journal of the European Academy of Dermatology and Venereology》2006,20(1):79-83
We report the case of a patient with a 13-year history of pemphigus vulgaris (PV) treated with immunosuppressive agents, prednisone and mycophenolate mofetil who had developed lesions of Kaposi's sarcoma (KS) on a sole plaque of PV that had been previously treated with intralesional injections of steroids. The lesions were surgically removed and polymerase chain reaction (PCR) demonstrated human herpesvirus-8 (HHV-8) DNA. There were neither recurrences nor later dissemination of KS following gradual decrease of the immunosuppressive therapy. We suggest that the treatment with intralesional steroids may have influenced the local reactivation of a latent infection of the virus, determining the appearance of this localized KS. 相似文献
4.
Kamil Torres Anna Torres Grzegorz J. Staśkiewicz Andrzej Chrościcki Tadeusz Łoś Ryszard Maciejewski 《Surgical endoscopy》2009,23(9):2117-2123
Background Surgical procedures enhance production of pro- and anti-inflammatory cytokines and angiogenic factors that play a pivotal
role in the immunological response to surgical trauma and take part in the pathogenesis of tumor growth and adhesions formation.
The purpose of the study was to access the influence of low-pressure CO2 pneumoperitoneum on the inflammatory and angiogenic responses during the postoperative period after laparoscopy.
Methods The study group consisted of 40 patients, operated on due to cholelithiasis using standard-pressure (n = 20) and low-pressure (n = 20) CO2 pneumoperitoneum. Serum concentration of interleukin (IL)-6, IL-8, IL-10, vascular endothelial growth factor (VEGF)-A, and
endostatin were measured before and at 6, 24, and 48 h after surgery with commercially available enzyme-linked immunosorbent
assay (ELISA).
Results Concentrations of IL-6 increased significantly after the operations in both groups. No differences were observed between the
groups in regards to IL-6, IL-8, and IL-10 levels. Concentrations of VEGF-A measured at 6 and 48 h were significantly lower
in patients who underwent laparoscopies performed with low-pressure pneumoperitoneum. No significant variations were observed
in endostatin serum concentration. Concentrations of the studied parameters were not influenced by duration of surgery or
by age, gender, or body mass index (BMI) of the patients.
Conclusions The results obtained in our study do not show any significant differences between studied operative procedures with regards
to systemic inflammatory response. Changes in the concentrations of VEGF-A and endostatin observed in the studied population
may suggest this technique is more favorable with regards to angiogenesis process intensity, along with all its consequences
and implications. 相似文献
5.
6.
CM Reid M. Nelson P. Beckinsale P. Ryan LMH Wing LJ Beilin MA Brown GLR Jennings CI Johnston J. Marley JJ McNeil TO Morgan J. Shaw ID Steven MJ West 《Clinical and experimental pharmacology & physiology》1997,24(5):370-373
1. The present study aimed to determine the feasibility of conducting a 5 year cardiovascular outcome trial of the treatment of 6000 elderly hypertensive patients in Australian general practices. 2. General practitioners (GPs) were invited to participate by mail and personal follow-up. Patient records were reviewed to identify subjects for a blood pressure (BP) screening programme. Blood pressure was measured on three occasions and eligible subjects were included if the average BP was 160 mmHg systolic or 90 mmHg diastolic if systolic BP was 140 mmHg. 3. Seven hundred and forty-one GPs were approached and 89 were enrolled in the study (12% of mail invites and 75% of those receiving a personal contact). In 16 practices where screening was completed, 82 000 records were reviewed to identify 4% patients eligible for screening. Twenty-two per cent of eligible subjects attended screening. Of 1938 subjects screened, 180 (9%) had BP 5=160/90 mmHg. Forty-seven percent of subjects (n = 916) were receiving antihypertensive therapy and 184 (20%) were withdrawn from therapy. One hundred and sixteen (63%) of these subjects had BP return to study entry levels within 6 weeks. Fifty-seven newly diagnosed and 81 previously treated subjects were randomized (7% of the screened population). 4. Based on the high participation rate of GPs, the response rate of patients to attend a BP screening programme and the 7% randomization to screening ratio for entry into the study, the ANBP2 pilot study has demonstrated that it is feasible to recruit subjects from Australian general practices to a cardiovascular outcome trial. 相似文献
7.
8.
The aim of the study was the investigation of the biochemical condition of elements likely to directly participate in active
closing of the urethral lumen. We estimated glycogenolysis in urinary bladder, perivesical connective tissue and levator ani
muscle (LAM) samples obtained intraoperatively from 80 stress incontinent women. Glycogen content as well as activities of
active and total glycogen phosphorylase and acid exo-1,4-alpha-glucosidase were measured. Material from the urinary bladder
and perivesical connective tissue was insignificantly altered, and glycogen contents in the bladder (2.03±1.38 g/100 g wet
tissue) were considered to be normal. In the LAM glycogenolysis was much more activated than in other tissues (p<0.001 by
Fischer's exact test). Of LAM specimens 78% (22/28) revealed imbalanced biochemistry of glycogen with activation of hydrolytic
decomposition. We conclude that stress urinary incontinence in women is frequently associated with metabolic alterations in
the periurethral striated fibres. This study indirectly supports our recent hypothesis on the pathogenesis of the disease
in terms of muscle fibre type transitions. 相似文献
9.
10.
SUMMARY A young patient presenting with splenomegaly and hypersplenism was inadvertently found to have selective IgA deficiency. There were no symptoms of immunodeficiency and the patient responded well to splenectomy, with return of blood counts to normal without adverse effects. No other cause for the hypersplenism was found. We postulate selective IgA deficiency as a cause of splenomegaly and hypersplenism. 相似文献