全文获取类型
收费全文 | 676篇 |
免费 | 59篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 23篇 |
妇产科学 | 44篇 |
基础医学 | 78篇 |
口腔科学 | 27篇 |
临床医学 | 76篇 |
内科学 | 93篇 |
皮肤病学 | 20篇 |
神经病学 | 19篇 |
特种医学 | 80篇 |
外科学 | 64篇 |
综合类 | 25篇 |
一般理论 | 2篇 |
预防医学 | 74篇 |
眼科学 | 26篇 |
药学 | 37篇 |
中国医学 | 1篇 |
肿瘤学 | 52篇 |
出版年
2021年 | 6篇 |
2019年 | 6篇 |
2018年 | 10篇 |
2017年 | 6篇 |
2016年 | 14篇 |
2015年 | 10篇 |
2014年 | 20篇 |
2013年 | 30篇 |
2012年 | 17篇 |
2011年 | 20篇 |
2010年 | 38篇 |
2009年 | 34篇 |
2008年 | 17篇 |
2007年 | 23篇 |
2006年 | 22篇 |
2005年 | 20篇 |
2004年 | 24篇 |
2003年 | 15篇 |
2002年 | 10篇 |
2001年 | 18篇 |
2000年 | 16篇 |
1999年 | 19篇 |
1998年 | 38篇 |
1997年 | 26篇 |
1996年 | 17篇 |
1995年 | 16篇 |
1994年 | 14篇 |
1993年 | 11篇 |
1991年 | 8篇 |
1990年 | 9篇 |
1989年 | 14篇 |
1988年 | 9篇 |
1987年 | 8篇 |
1985年 | 10篇 |
1984年 | 6篇 |
1983年 | 6篇 |
1982年 | 11篇 |
1981年 | 7篇 |
1980年 | 12篇 |
1979年 | 6篇 |
1978年 | 6篇 |
1977年 | 9篇 |
1975年 | 9篇 |
1972年 | 9篇 |
1970年 | 7篇 |
1969年 | 9篇 |
1968年 | 5篇 |
1967年 | 6篇 |
1966年 | 7篇 |
1914年 | 5篇 |
排序方式: 共有751条查询结果,搜索用时 15 毫秒
1.
Andy KH Lim 《World journal of gastroenterology : WJG》2020,26(10):1020-1028
Rhabdomyolysis is a syndrome of skeletal muscle injury with release of cellular constituents such as potassium,phosphate,urate and intracellular proteins such as myoglobin into the circulation,which may cause complications including acute kidney injury,electrolyte disturbance and cardiac instability.Abnormal liver function tests are frequently observed in cases of severe rhabdomyolysis.Typically,there is an increase in serum aminotransferases,namely aspartate aminotransferase and alanine aminotransferase.This raises the question of liver injury and often triggers a pathway of investigation which may lead to a liver biopsy.However,muscle can also be a source of the increased aminotransferase activity.This review discusses the dilemma of finding abnormal liver function tests in the setting of muscle injury and the potential implications of such an association.It delves into some of the clinical and experimental evidence for correlating muscle injury to raised aminotransferases,and discusses pathophysiological mechanisms such as oxidative stress which may cause actual liver injury.Serum aminotransferases lack tissue specificity to allow clinicians to distinguish primary liver injury from muscle injury.This review also explores potential approaches to improve the accuracy of our diagnostic tools,so that excessive or unnecessary liver investigations can be avoided. 相似文献
2.
3.
4.
王伏虎 《南京医科大学学报(英文版)》2002,16(2):49-64
Stroke is a debilitating disease that affects millions each year.While in many cases cerebral ischemic in jury can be limited by effectivw resuscitation or thrombolytic treatment,the injured neurons wither in a process known as delayed neuronal death(DND).Mounting evidence indicates that DND is not simply necrosis played out in slow motion but apoptosis is triggered.Of particular interest are two groups of signal proteins that participate in apoptosis-cyclin dependent kinases(CDKs) and p53-among a myriad of signaling events after an ischemic insult.Recent investigations have shown that CDKs,a family of enzymes initially known for their role in cell cycle regulation,are activated in injured neurons in DND.As for p53,new reports suggest that its up-regulation may represent a failed attempt to rescue in jured neurons,although its up-regulation was previously considered an indication of apoptosis.These observations thus rekindle an old quest to identify new neuroprotective targets to minimize the stroke damage.In this review,the author will examine the evidence that indicates the participation of CDKs and p53 in DND and then introduce pre-clinical data to explore CDK inhibition as a potential neuroprotective target.Finally,using CDK inhibition as an example,this paper will discuss the pertinent criteria for a viable neuroprotective strategy for ischemic in jury. 相似文献
5.
6.
D L Weed 《American journal of public health》1995,85(7):914-918
Epidemiologists may benefit from the disciplines of history, philosophy of science, ethics, literature, and art. Within these disciplines lie answers to the questions of who we are, what is right, how to think, and when to act. Studying and participating in the humanities may also help epidemiologists focus their professional concerns on the humanity their methods serve. A parallel phenomenon in the clinical sciences--medical humanities--provides support for the approach (and some lessons). 相似文献
7.
Androgen receptor YAC transgenic mice carrying CAG 45 alleles show trinucleotide repeat instability 总被引:1,自引:15,他引:1
La Spada AR; Peterson KR; Meadows SA; McClain ME; Jeng G; Chmelar RS; Haugen HA; Chen K; Singer MJ; Moore D; Trask BJ; Fischbeck KH; Clegg CH; McKnight GS 《Human molecular genetics》1998,7(6):959-967
X-linked spinal and bulbar muscular atrophy (SBMA) is caused by a CAG
repeat expansion in the first exon of the androgen receptor (AR) gene.
Disease-associated alleles (37-66 CAGs) change in length when transmitted
from parents to offspring, with a significantly greater tendency to shift
size when inherited paternally. As transgenic mice carrying human AR cDNAs
with 45 and 66 CAG repeats do not display repeat instability, we attempted
to model trinucleotide repeat instability by generating transgenic mice
with yeast artificial chromosomes (YACs) carrying AR CAG repeat expansions
in their genomic context. Studies of independent lines of AR YAC transgenic
mice with CAG 45 alleles reveal intergenerational instability at an overall
rate of approximately 10%. We also find that the 45 CAG repeat tracts are
significantly more unstable with maternal transmission and as the
transmitting mother ages. Of all the CAG/CTG repeat transgenic mice
produced to date the AR YAC CAG 45 mice are unstable with the smallest
trinucleotide repeat mutations, suggesting that the length threshold for
repeat instability in the mouse may be lowered by including the appropriate
flanking human DNA sequences. By sequence-tagged site content analysis and
long range mapping we determined that one unstable transgenic line has
integrated an approximately 70 kb segment of the AR locus due to
fragmentation of the AR YAC. Identification of the cis - acting elements
that permit CAG tract instability and the trans -acting factors that
modulate repeat instability in the AR YAC CAG 45 mice may provide insights
into the molecular basis of trinucleotide repeat instability in humans.
相似文献
8.
Two calcium alginate-tipped wire swab specimens were obtained from 94 men and 106 women attending a sexually transmitted disease clinic. One swab was extracted thoroughly in 2-sucrose phosphate (2SP) immediately after obtaining the specimen. The second swab was returned to the Culturette cylinder (Marion Scientific, Kansas City, MO), and the ampule containing 2SP was crushed to moisten the swab during transport to the laboratory. After receipt in the laboratory, the swab was removed from the Culturette and extracted into 2 mL of 2SP. Both specimens then were cultured for the presence of Chlamydia trachomatis in McCoy's cells. C. trachomatis was recovered from 22 of 94 men (23.4%); 16 isolates came from both the Culturette swabs and vials. Six isolates were recovered exclusively from vials. Of 106 women, 13 (12.3%) were positive for C. trachomatis. In five instances, both vials and swabs yielded C. trachomatis; the organism was recovered eight times from vials but not swabs. The 2SP transport system for the 200 specimens was superior to the Culturettes for the recovery of C. trachomatis (P less than 0.01). Based on our results, swab specimens taken for laboratory diagnosis of C. trachomatis should be extracted immediately after collection in a vial containing 2SP. In addition, experiments comparing swab fibers indicated that there was a trend indicating higher inclusion counts with rayon-tipped swabs, compared with those containing calcium alginate. Because of possible toxicity of substances in calcium alginate fibers for several organisms causing sexually transmitted disease, rayon-tipped swabs or swabs of other composition should be used. 相似文献
9.
Bronchopulmonary helminthosporiosis 总被引:5,自引:0,他引:5
10.
Founder effect in spinal and bulbar muscular atrophy (SBMA) 总被引:3,自引:2,他引:3
Tanaka F; Doyu M; Ito Y; Matsumoto M; Mitsuma T; Abe K; Aoki M; Itoyama Y; Fischbeck KH; Sobue G 《Human molecular genetics》1996,5(9):1253-1257
We analyzed the polymorphic (CAG)n and (GGC)n repeats of the androgen
receptor gene in 113 unrelated X-linked spinal and bulbar muscular atrophy
(SBMA) X chromosomes and 173 control X chromosomes in Japanese males. The
control chromosomes had an average CAG repeat number of 21 +/- 3 with a
range from 14-32 repeat units, and SBMA chromosomes had a range from 40-55
with a median of 47 +/- 3 copies. The control chromosomes had seven
different alleles of the (GGC)n repeat with the range of 11 to 17; the most
frequent size of (GGC)n was 16 (79%), while (GGC)17 was very rare (1%).
However, in SBMA chromosomes only two alleles were seen; the most frequent
size of (GGC)n was 16 (61%) followed by 17 (39%). (GGC)n size distribution
was significantly different between SBMA and control chromosomes (P <
0.0001), indicating the presence of linkage disequilibrium. There was no
allelic association between the (CAG)n and (GGC)n microsatellites among
control subjects as well as SBMA patients, which suggests that a founder
effect makes a more significant contribution to generation of Japanese SBMA
chromosomes than new mutations.
相似文献