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Saipin Chotivichien Lenore Arab Wisit Prasithsirikul Weerawat Manosuthi Sangsom Sinawat 《AIDS care》2016,28(2):257-265
HIV-infected patients receiving antiretroviral therapy have increased risk of metabolic syndrome, including dyslipidemia. In this study, we determined whether individual nutritional counseling reduced dyslipidemia, particularly low-density lipoprotein (LDL) cholesterol, among HIV-infected patients with dyslipidemia not currently taking lipid-lowering medication. We conducted a randomized 24-week trial among HIV-infected patients with dyslipidemia who were on antiretroviral therapy and were eligible to initiate therapeutic lifestyle changes according to the Thai National Cholesterol Education Program. Participants were randomly assigned to an intervention group that received individual counseling with a nutritionist for seven sessions (baseline, weeks 2, 4, 8, 12, 18, and 24) and a control group that received standard verbal diet information at baseline and nutritional counseling only at week 24. A 24-h recall technique was used to assess dietary intake for both groups at baseline and week 24. Lipid profile (total cholesterol, LDL, high-density lipoprotein (HDL), and triglyceride) was measured at baseline and after 12 and 24 weeks of therapy. An intention-to-treat and linear mixed model were used. Seventy-two patients were randomly assigned, and 62 (86%) participants completed their lipid profile test. After 12 weeks of follow-up, there were significant reductions in the intervention group for total cholesterol (?14.4?±?4.6?mg/dL, P?=?.002), LDL cholesterol (?13.7?±?4.1?mg/dL, P?=?.001), and triglyceride (?30.4?±?13.8?mg/dL, P?=?.03). A significant reduction in LDL cholesterol was also observed in the control group (?7.7?±?3.8?mg/dL, P?=?.04), but there were no significant differences in change of mean lipid levels between the groups at 12 weeks of follow-up. After 24 weeks, participants assigned to the intervention group demonstrated significantly greater decreases in serum total cholesterol (?19.0?±?4.6?vs. 0.2?±?4.3?mg/dL, P?=?.003) and LDL cholesterol (?21.5?±?4.1?vs. ?6.8?±?3.8?mg/dL, P?=?.009). There were no significant changes in HDL cholesterol or triglyceride levels in either group. 相似文献
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Dmitry Olegovich Bokov Mustafa Z. Mahmoud Gunawan Widjaja Wanich Suksatan Supat Chupradit Usama S. Altimari Hussein Ali Hussein Yasser Fakri Mustafa Milad kazemnejadi 《RSC advances》2022,12(18):10933
A reductive filter paper for selective nitro reduction has been prepared by modification of a pristine cellulose filter paper by Pd/C nanoparticles, as a portable catalyst. The reaction was performed in two different set-ups including (i) filtration and (ii) sealed systems, in the presence of ammonium formate and ex situ generated hydrogen gas reducing agents, respectively. In the sealed system in the presence of H2 gas, the halogenated nitroarenes were completely reduced, while in the filtration system, different derivatives of the nitroarenes were selectively reduced to aryl amines. In both systems, the reduction of nitroarenes to aryl amines was performed with high efficiency and selectivity, comparable to a heterogeneous system. Reaction parameters were comprehensively designed using Design Expert software and then studied. The properties of the catalytic filter paper were studied in detail from the points of view of swellability, shrinkage, reusability, and stability against acidic, alkaline, and oxidative reagents.A novel and efficient catalytic filtration has been developed for the selective reduction of nitro compounds on a Pd/C-doped cellulose filter paper. 相似文献
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Tansuphasawadikul S Saito W Kim J Phonrat B Dhitavat J Chamnachanan S Pitisuttithum P 《The Southeast Asian journal of tropical medicine and public health》2007,38(6):1053-1060
HIV-infected patients with active tuberculosis (TB) having CD4 counts < 100/mm3 and who were antiretroviral therapy (ART) na?ve were reviewed retrospectively to determine the outcomes of their tuberculosis infection. All patients received ART at or after receiving anti-TB treatment. Clinical manifestations, treatment regimens and outcomes were analyzed. Of 101 patients, 62 (61.4%) completed TB treatment. Of these, 53.2% were treated with a 6-month standard TB regimen, while the rest were treated with prolonged TB regimens. The median interval between anti-TB treatment and ART was 68 days (range: 0-381). Among the clinically cured patients 66.1% received rifampin concomitantly with nevirapine, and 32.3% received rifampin concomitantly with efavirenz. The treatment success rate was 75.6%, with a mortality rate of 6.1%. The risk factors for death were resistant TB (p = 0.03) and poor compliance (p < 0.05). Seven point nine percent had multi-drug resistant TB. Possible or probable immune reconstitution inflammatory syndrome (IRIS) was seen in 15 cases (14.9%). No life-threatening IRIS was reported, and it did not affect disease outcome (p = 0.5). A shorter time between anti-TB treatment and ART onset was associated with the occurrence of IRIS (31 days vs 90 days; p < 0.05). Regarding adverse drug effects, 44.6% had side effects due either to anti-TB drugs or ART. Sixty-six point one percent of them occurred within the first 2 months of TB treatment, and 43 (76.8%) had to stop or change either anti-TB treatment or ART. The mortality rate with TB and HIV on ART was low and the occurrence of IRIS did not carry any additional mortality. 相似文献
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C S Pandav K Anand S Sinawat F U Ahmed 《The Southeast Asian journal of tropical medicine and public health》2000,31(4):762-768
In Thailand, iodine deficiency disorders (IDD) are endemic in 57 out of 75 provinces with an estimated 15 million people at risk of IDD. A three pronged control program with iodized salt, iodized water and iodized oil capsules is being implemented. The water iodization program is both school based and household based. In the household, the residents are given iodine solution, two drops of which is to be added to 10 l of drinking water. In the schools, in addition to this method, an iodinator is used. This releases a fixed amount of iodine into the drinking water. This study examines the cost of the water iodization program in Thailand for the year 1996 in terms of cost per beneficiary, cost per microg iodine consumed daily and cost per goiter person years averted. We used a discount rate of 5%. Field visit and interviews of health personnel from Ministry to village level were conducted to gather primary data. Review of existing papers and reports of the Department of Health, Government of Thailand was done for secondary data. The costs included the capital cost of equipments, initial training and the recurrent costs of potassium iodate, proportional salaries of personnel involved, monitoring and communication activities. The cost per beneficiary of school based iodinator method (US$ 0.72) and school based drop method (US$ 0.64) were similar and much higher than the household based approach (US$ 0.12). The cost per microg of iodine consumed daily was ten times higher in the school based approach (US$ 0.01) compared to the household approach (US$ 0.001). The cost per goiter case averted for the whole strategy of water iodization was US$ 194.50. Water iodization appears to be a low cost intervention. However, the need for behavioral modification raises the issue of long term sustainability. 相似文献
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Suwanwongse S Chasreechai S Lenbury Y Kataunyuthita S 《The Southeast Asian journal of tropical medicine and public health》2002,33(3):581-588
AIDS is a serious public health problem. Our projections of the likely incidence of AIDS are of vital importance to the assessment of future healthcare needs. This paper considers an epidemic model of the population dynamics of AIDS, which has been adjusted to take into account the changes in the transmission rate in response to changes in risk behaviors and increased AIDS awareness due to public health policy, AIDS campaigns, and other means of disease prevention. The model, adjusted for reporting delays and for the variable incubation period of the disease, has been applied to AIDS incidence data gathered in Nakhon Pathom, Thailand. Using the least-squares criterion, we solved for the appropriate values of the parameters which gave the best fit of the model to the observation data. The model was found to be capable of generating short-term projections, and offers an explanation for the decline in the number of cases that is evident in more recent data. 相似文献
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Punnee Pitisuttithum Kobporn Boonnak Supat Chamnanchanunt Pilaipan Puthavathana Viravarn Luvira Hatairat Lerdsamran Jaranit Kaewkungwal Saranath Lawpoolsri Vipa Thanachartwet Udomsak Silachamroon Wanibtisam Masamae Alexandra Schuetz Ponthip Wirachwong Sit Thirapakpoomanunt Larisa Rudenko Erin Sparrow Martin Friede Marie-Paule Kieny 《The Lancet infectious diseases》2017,17(8):833-842
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Benjaluck Phonrat Punnee Pitisuttithum Supat Chamnanchanunt Pilaipan Puthavathana Nathamon Ngaosuwankul Suda Louisirirotchanakul Jittima Dhitavat Sit Thirapakpoomanunt Vichai Chokevivat Suwit Wibulpolprasert 《Vaccine》2013