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1.
Gastrointestinal hormone receptors on isolated smooth muscle cells from gastric antrum of the rabbit 总被引:1,自引:0,他引:1
The regulation by gastrointestinal polypeptide hormones of contraction and relaxation of functionally isolated smooth muscle cells from gastric antrum of the rabbit has been investigated. Gastrin, cholecystokinin (CCK-8) and motilin induced a rapid contraction of isolated cells: significant response occurred within a 5-sec incubation with these peptides and maximal response (40% decrease in cell length) after 30 sec. A higher sensitivity of smooth muscle cells to gastrin and CCK-8 than to motilin stimulations was demonstrated (EC50 = 10 pM for both gastrin and CCK-8 and EC50 = 1 nM for motilin). The minimal gastrin fragment required to get full contraction was the C-terminal pentapeptide amide common to gastrin and CCK. Proglumide inhibited gastrin- or CCK-8- but not motilin-induced contractions with an IC50 of 50 microM. contraction induced by gastrin and motilin required normal levels of extracellular calcium, whereas that due to CCK-8 seemed to be independent of extracellular calcium. Vasoactive intestinal polypeptide (VIP) caused a relaxation of smooth muscle cells maximally contracted by carbachol or CCK-8 or gastrin (EC50 = 2.2 nM) with a parallel increase in intracellular cAMP content. 相似文献
2.
U N Jindal 《The international journal of tuberculosis and lung disease》2006,10(9):1045-1050
SETTING: A private infertility care and in vitro fertilisation (IVF) centre in Northern India. OBJECTIVES: To describe the prevalence, clinical spectrum, management strategy and outcome of infertility due to female genital tuberculosis (GTB) diagnosed with the help of a simplified tuberculosis (TB) algorithm. DESIGN: Data from 150 women with infertility (Group I) and 47 women with general gynaecological problems (Group II) were analysed. RESULTS: GTB was diagnosed in 7.2% of Group I and 2.8% of Group II women. Anti-tuberculosis treatment resulted in resolution of symptoms other than infertility in over 90% of cases. Of the total 20 pregnancies in the group, 10 were obtained in 32 IVF treatment patients. CONCLUSIONS: A definitive bacteriological diagnosis was generally difficult to achieve in GTB before administration of anti-tuberculosis treatment. A high index of suspicion and several other morphological and/or laboratory criteria were employed. It is suggested that a step-wise algorithm can help in the management of these cases. 相似文献
3.
4.
R Guleria Y K Batra B K Sharma S K Jindal 《The Indian journal of chest diseases & allied sciences》1992,34(3):149-152
A patient of chronic obstructive pulmonary disease (COPD) with cor-pulmonale and chronic respiratory failure, who was given intermittent positive pressure ventilation at home, is reported. The patient did remarkably well on home mechanical ventilatory support. We believe this to be the first case report of domiciliary mechanical ventilation in a patient of COPD from India. 相似文献
5.
Arinsoy T; Yilmaz M; Ataoglu O; Bali M; Sindel S 《Nephrology, dialysis, transplantation》1997,12(12):2713-2716
6.
7.
K. S. Kohli D. V. Rai P. Kumar V. K. Jindal Dr. N. Goyal 《Medical & biological engineering & computing》1997,35(4):348-353
The complex electrical impedance of a goat eye lens is studied in the frequency range 10mHz−10Hz at room temperature, using
a computer-controlled AC impedance system. AC impedance software (model 368, version 2.2) is employed to determine the total
impedance and capacitance of the eye lens at various frequencies. A Cole-Cole plot of the eye lens material is drawn between
the real component of impedance Z′ and the imaginary component Z″ for each excitation frequency that shows a perfect arc of
a semicircle, with its centre lying below the abscissa at an angle of 35°. The half-angle ϕ between R0 and R∞ is found to be 55°, which mathematically demonstrates the selective permeability of the eye lens. Using graphical analysis
of the Cole-Cole plot, characteristic frequency fc and distribution factor α are observed to be 1Hz and 0.77, respectively. At characteristic frequency, capacitance and total
impedance are found to be 1.14μF and 9.08kΩ. The effect of electrode polarisation on capacitance is corrected, based on Fricke's
power function. The observed electrical parameters are then used to explain the multiple current path through various tissue
compartments. Further, an attempt is made to explain the results on the basis of a possible dipolar model. 相似文献
8.
Mathur SK Singh S Marwah N Jindal R Arora B Rattan KN 《Indian journal of pathology & microbiology》2004,47(2):261-263
Pancreatoblastoma or infantile pancreatic carcinoma is a rare pancreatic tumor with distinct acinar and squamoid cell differentiation that generally affects infants and young children. Ultrasound and CT scan may be useful but preoperative diagnosis is often quite difficult. The outcome is generally favourable. A such case of 10 years old boy with an abdominal mass is being presented. 相似文献
9.
K. S. Kohli Dr. D. V. Rai V. K. Jindal N. Goyal 《Medical & biological engineering & computing》1998,36(5):604-607
A computer assisted AC impedance system is used to measure the DC voltage—current (V-I) characteristics and AC impedance of
a goat eye lens using a two-probe Ag−AgCl electrode system. The measurement of the V-I characteristics shows that when a DC
voltage from 0mV to 30mV is applied, the resultant current decreases from an initial value of 0.58μA to 0.006μA. However,
when the voltage is increases beyond 30mV, the current increases and reaches a value of 0.9μA at 100mV. The data on the frequency
response (0.01–10 Hz) of the impedance of lens tissue show an inverse relationship with frequency. The effect of various DC
voltages, namely 0, 30, 50, 100 and 200 mV, on the impedance of the eye lens is also investigated over a frequency range of
0.01–10 Hz. The measurement results for both V-I characteristics and AC impedance further suggest the presence of a 30 mV
voltage compartment in the goat eye lens. 相似文献
10.
A K Deshpande G D Jindal I P Babu S N Nerurkar M D Kelkar G B Parulkar 《Journal of postgraduate medicine》1990,36(2):80-82
Impedance plethysmographic observations have been correlated with aortographic observations in 57 patients suspected of aortic occlusive diseases. Aortic occlusions have been characterised by marked decrease in blood flow index and significant increase in differential pulse arrival time at thigh level bilaterally. Atherosclerotic affection of the aorta has been featured by a bilateral decrease in the value of blood flow index as well as differential pulse arrival time at thigh level. Leriche's syndrome, however, has been found to decrease the blood flow index moderately at thigh in both the legs without any significant change in differential pulse arrival time. Aortography in all the patients has confirmed the diagnosis made by impedance plethysmography. 相似文献