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排序方式: 共有152条查询结果,搜索用时 31 毫秒
1.
Sphincter of Oddi Motor Activity in Patients with Anomalous Pancreaticobiliary Junction 总被引:3,自引:0,他引:3
Shinji Matsumoto M.D. Masao Tanaka M.D. Seiyo Ikeda M.D. Hideo Yoshimoto M.D. 《The American journal of gastroenterology》1991,86(7):831-834
Sphincter of Oddi motor activity was investigated in seven patients with an anomalous pancreaticobiliary junction and in six controls by endoscopic manometry under fluoroscopy. Characteristic phasic wave activity was observed in the sphincter segment in both groups. Amplitude of the phasic contractions was significantly higher in the disease group than in controls (100.8 +/- 14.1 mm Hg vs. 55.2 +/- 4.3 mm Hg, p less than 0.02). Although those with the anomalous pancreaticobiliary junction had a longer common channel (15-30 mm), the length of the sphincter segment with the phasic wave activity was not different. The phasic activity was not seen at the junction of the pancreatic and bile ducts in disease groups. Bile obtained from within the bile duct showed a very high concentration of amylase. Morphine given to cause spasm of the sphincter increased basal pressure and frequency of the phasic waves in all controls. The response to morphine was similar in two patients in whom the anomalous junction was studied, but the procedure was complicated by acute pancreatitis in one of them. These findings suggest that contractions of the sphincter of Oddi in patients with the anomalous junction may contribute to reflux between the pancreatic and bile ducts, leading to various pathologic conditions associated with this anomaly. 相似文献
2.
Yamamoto J Ohshima K Kohno S Ichimiya H Nakagaki M Yao T Iwasaki H Ikeda S 《Surgery today》2005,35(6):488-492
Extremely well differentiated primary gastric adenocarcinoma, which accounts for less than 0.2% of all gastric cancers, is associated with a better prognosis than other types of differentiated adenocarcinoma. Among 2070 gastric carcinomas, diagnosed between 1983 and 2002 at Fukuoka University Hospital and Hamanomachi Hospital, there were three cases of primary extremely well differentiated adenocarcinoma. We report the clinicopathological details of one case of primary gastric extremely well differentiated adenocarcinoma. A 57-year-old man was reffered to our hospital for investigation and treatment of a gastric tumor. Physical and laboratory examinations revealed no abnormalities except for diabetes mellitus. Radiological, endoscopic, and imaging examinations showed an esophageal achalasia-like stenotic lesion. The surface mucosa consisted of almost normal epithelium without any signs of malignancy. Macroscopically, the surgical specimen contained a submucosal tumor, and histological examination revealed extremely well differentiated adenocarcinoma. Although this type of carcinoma is very rare, it should be considered in the differential diagnosis of esophageal and gastric mucosal lesions. 相似文献
3.
Relationship of biliary pressure to cholangiovenous reflux during endoscopic retrograde balloon catheter cholangiography 总被引:2,自引:0,他引:2
Hideo Yoshimoto MD Seiyo Ikeda MD Masao Tanaka MD Shinji Matsumoto MD 《Digestive diseases and sciences》1989,34(1):16-20
In 32 patients undergoing endoscopic retrograde cholangiography with a balloon catheter, culture of bile, biliary pressure at maximal visualization of the biliary tract with iodinated contrast medium, serum iodine concentrations, and blood cultures before and after the procedure were obtained. There was a significant increase in the serum iodine concentration in five of nine patients (55.6%) with pressure between 22 cm H2O and 30 cm H2O and in nine of 13 patients (69.2%) with pressure above 30 cm H2O, while it remained low in 10 patients with pressure below 22 cm H2O. Two patients showed positive blood culture after the procedure, which yielded the same organisms as found in the bile. The biliary pressures in these two patients were 30.4 cm H2O and 38.0 cm H2O. These data suggest that during retrograde balloon catheter cholangiography: (1) cholangiovenous reflux of contrast medium develops with biliary pressure higher than 22 cm H2O, (2) the indicence of the cholangiovenous reflux increases as the pressure is elevated, and (3) regurgitation of bacteria occurs with pressure greater than 30 cm H2O. These findings are noteworthy because the number of patients who need direct cholangiography is increasing. 相似文献
4.
Plasma endothelin-1 levels depress optic nerve head circulation detected during the glucose tolerance test 总被引:1,自引:0,他引:1
Teruyo Kida Tetsuya Sugiyama Hidehiro Oku Seiyo Harino Tsunehiko Ikeda 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2007,245(9):1289-1293
Purpose To determine the relationship between the changes in optic nerve head (ONH) circulation and the level of plasma endothelin-1
(ET-1) during the glucose tolerance test (GTT).
Methods Twenty-six healthy volunteers with normal GTT and 15 patients with mild hyperglycemia and abnormal GTT were studied. The ONH
circulation [square blur rate (SBR) value], blood pressure, intraocular pressure (IOP), blood glucose, blood insulin and plasma
ET-1 were determined before and every hour up to 3 h after an oral intake of 75 g of glucose.
Results The SBR increased in the normal glucose tolerance group at all times during the GTT, but it decreased significantly in the
abnormal glucose tolerance group (P < 0.05). Before the GTT, the plasma ET-1 level was not significantly different in the two groups; however, the level increased
1 h after the oral GTT in the abnormal glucose tolerance group (P < 0.05). No significant changes were observed in mean blood pressure or IOP.
Conclusions ONH circulation increased after glucose intake in the normal glucose tolerance group and remained high even after the blood
glucose level had returned to its baseline. The decrease in ONH circulation in the abnormal glucose tolerance group was attributed
partly to the increased ET-1. 相似文献
5.
Two-year follow-up study comparing primary vitrectomy with scleral buckling for macula-off rhegmatogenous retinal detachment 总被引:5,自引:0,他引:5
Oshima Y Yamanishi S Sawa M Motokura M Harino S Emi K 《Japanese journal of ophthalmology》2000,44(5):538-549
PURPOSE: To compare the anatomic and visual outcomes achieved by scleral buckling and primary vitrectomy for the repair of macula-off rhegmatogenous retinal detachment. METHODS: The records were reviewed for a consecutive series of 167 patients (167 eyes) who were initially treated with scleral buckling or pars plana vitrectomy for primary macula-off retinal detachment. Patients were treated between January 1993 and December 1996. After adjustments for preoperative characteristics, data from 102 cases (55 scleral buckle cases and 47 primary vitrectomy cases) were used for the final comparison. There had been a minimum follow-up period of 24 months. RESULTS: No significant differences in single-procedure reattachment incidence (91%), final success incidence (100%) and incidence of postoperative proliferative vitreoretinopathy development (4%) were observed between the two treatment groups. Preoperative visual acuity, preoperative intraocular pressure, and duration of macular detachment were the three best predictors of postoperative visual recovery in both groups. Favorable overall visual recovery was obtained postoperatively, with no significant differences between the two groups throughout the follow-up period. However, in the eyes with poor preoperative visual acuity (<0.1), ocular hypotony (intraocular pressure <7 mm Hg), or prolonged macular detachment (more than 7 days), visual recovery in the primary vitrectomy group was significantly better (P <.05) than in the scleral buckle group from the first postoperative month. CONCLUSION: Both procedures achieved favorable anatomic and visual outcomes in the majority of patients with primary macula-off retinal detachment. Primary vitrectomy may be more effective than scleral buckling for achieving early visual rehabilitation in cases complicated by poor preoperative vision, ocular hypotony, and prolonged macular detachment. 相似文献
6.
Real time fixation point monitoring system for photocoagulation of juxtafoveal neovascularisation 下载免费PDF全文
Harino S Iwahashi Y Oshima Y Sawa M Nakamura H 《The British journal of ophthalmology》2000,84(9):1053-1055
BACKGROUND/AIMS: A new real time monitoring system has been developed to locate the fixation point during juxtafoveal laser photocoagulation. METHOD: The red diode laser beam is combined coaxially with the illumination beam to image a cross in the focal plane of the slit lamp, which allows projection of a red cross onto the patient's fundus. 27 patients with juxtafoveal choroidal neovascularisation were treated by photocoagulation using this system. RESULTS: 13 (48%) patients whose visual acuity ranged from 20/200 to 20/40 answered that it was easier to keep the focus on the cross target image than on the aiming beam. The patient maintained stable fixation throughout the treatment. The laser treatment was completed without foveal damage near the fixation point in all patients. CONCLUSION: The real time fixation monitoring system should allow surgeons to treat juxtafoveal lesions with laser photocoagulation more safely and accurately. 相似文献
7.
Ouchi M Ikeda T Nakamura K Harino S Kinoshita S 《Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde》2002,216(5):363-367
To evaluate the relation between fatty acids and age-related macular degeneration (ARMD), the fatty acid fractions within the red blood cell (RBC) membrane and plasma of 11 ARMD patients and 10 healthy individuals (controls) were determined and compared. RBC arachidonic acid (AA) and docosahexaenoic acid (DHA) exhibited significantly higher values in the ARMD patients than in the controls. RBC levels of palmitic, palmitoleic, oleic and linoleic acids, however, showed significantly higher values in the controls than in the ARMD patients. No significant variations were observed between the two groups in terms of plasma levels of AA, DHA, palmitic, palmitoleic, oleic and linoleic acids. Our findings indicate that polyunsaturated fatty acids, vulnerable to free radicals and reactive oxygen species, and easily peroxidized, may be related to ARMD induction. 相似文献
8.
Shinagawa N Manabe T Takeyama H Hasegawa M Hirata K Mukaiya M Katsuramaki T Taniguchi M Ushijima Y Mashita K Aikawa N Sekine K Ishikawa S Mizuno A Iwai S Kato K Kinoshita H Morimoto K Sato T Fujimoto M Yura J Tanimura H Ohnishi H Maeda T Sueda T Takesue Y Tanaka N Iwagaki H Yokoyama T Hiyama E Fuchimoto S Inoue F Kimura H Ikeda S Yasunami Y Konaga E Takeuchi H Suzuki Y Nakane Y 《The Japanese journal of antibiotics》2002,55(6):730-763
Tendency of isolated bacteria from infections in general surgery and their antimicrobial susceptibilities during the period from April 2000 to March 2001 were investigated in a multicenter study in Japan, and the following results were obtained. The number of cases investigated as objectives was 234 for one year. A total of 388 strains (136 strains from primary infections and 252 strains from postoperative infections) were isolated from 165 cases (70.5% of total cases). In primary infections, anaerobic Gram-positive bacteria were predominant, while from postoperative infections, aerobic Gram-positive bacteria were predominant. Among aerobic Gram-positive bacteria, the isolation rate of Enterococcus faecalis was the highest, followed by that of Staphylococcus aureus from postoperative infections. Among anaerobic Gram-positive bacteria, the isolation rate of Peptostreptococcus spp. was the highest from both types of infections. Among aerobic Gram-negative bacteria, Escherichia coli was the most predominantly isolated from primary infections, followed by Klebsiella pneumoniae and Pseudomonas aeruginosa in this order, and from postoperative infections, P. aeruginosa was the most predominantly isolated, followed by Enterobacter spp. and Klebsiella spp. Among anaerobic Gram-negative bacteria, the isolation rate of Bacteroides fragilis group was the highest from both types of infections. There was no vancomycin-resistant S. aureus nor Enterococcus spp. Among anaerobic bacteria, there were many resistant strains against penicillins and cephems with MICs higher than 100 micrograms/ml, and the same trend was observed among other Bacteroides spp. and Prevotella spp. 相似文献
9.
Abe R Tominaga T Nomizu T Nomura Y Takashima S Koyama H Sano M Tohge T Ueo H Ikeda S Ohashi Y;CGS Study Group 《Gan to kagaku ryoho. Cancer & chemotherapy》2002,29(5):729-740
To determine the recommended clinical dose of CGS20267 (Letrozole), we conducted a randomized comparative study as a late phase II study (first part) in postmenopausal women with advanced or recurrent breast cancer. Forty-one patients were randomly assigned to receive 0.5 mg or 1.0 mg once daily. There were no statistically significant differences in background between the two groups. Although there was no significant difference in the objective response rates between the two groups, the rate was higher at 1.0 mg (44.4%) than at 0.5 mg (38.1%). We also combined these data with the results of an early phase II study. The objective response rates (CR + PR) were 31.4% at 0.5 mg and 42.2% at 1.0 mg, and response rates consisting of CR, PR, and NC for longer than 6 months were significantly higher at a dose of 1.0 mg (68.9%) than 0.5 mg (41.2%). Side effects included drug-related adverse events in 36.8% at 0.5 mg and in 31.6% at 1.0 mg. All of the events were grade 2 or lower, indicating a favorable tolerability of CGS20267. These results demonstrated that CGS20267 1.0 mg once daily is more effective than 0.5 mg, and has comparable safety, in the treatment of postmenopausal women with advanced or recurrent breast cancer. We conclude the recommended clinical dose of CGS20267 should be 1.0 mg once daily. 相似文献
10.
Kimijima I Tominaga T Nomizu T Nomura Y Takashima S Koyama H Sano M Tohge T Ueo H Ikeda S Ohashi Y;CGS Study Group 《Gan to kagaku ryoho. Cancer & chemotherapy》2002,29(5):741-749
In the first part of this late phase II study, we determined the recommended clinical dose of CGS20267 to be 1.0 mg once daily for the treatment of postmenopausal women with advanced or recurrent breast cancer. To further evaluate the efficacy and safety of CGS20267 at the derived or recommended clinical dose, 30 more patients were enrolled in the second part of the study, and were added to the patients treated at 1.0 mg in the first part. As a result of putting the first and second parts together, the objective response rate at 1.0 mg was found to be 38.3%, which was almost equal to that of the early phase II study (40.7%). Drug-related adverse events occurred in 35.4% of the patients at 1.0 mg, and all of the events were of grade 2 or lower. These results demonstrated that CGS20267 1.0 mg once daily is effective and well tolerated in the treatment of postmenopausal women with advanced or recurrent breast cancer. 相似文献