全文获取类型
收费全文 | 1613篇 |
免费 | 84篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 37篇 |
儿科学 | 63篇 |
妇产科学 | 30篇 |
基础医学 | 117篇 |
口腔科学 | 22篇 |
临床医学 | 106篇 |
内科学 | 212篇 |
皮肤病学 | 101篇 |
神经病学 | 123篇 |
特种医学 | 128篇 |
外科学 | 314篇 |
综合类 | 50篇 |
预防医学 | 42篇 |
眼科学 | 23篇 |
药学 | 49篇 |
肿瘤学 | 289篇 |
出版年
2021年 | 11篇 |
2020年 | 12篇 |
2019年 | 10篇 |
2018年 | 24篇 |
2017年 | 18篇 |
2016年 | 12篇 |
2015年 | 17篇 |
2014年 | 28篇 |
2013年 | 36篇 |
2012年 | 56篇 |
2011年 | 43篇 |
2010年 | 49篇 |
2009年 | 46篇 |
2008年 | 48篇 |
2007年 | 64篇 |
2006年 | 63篇 |
2005年 | 77篇 |
2004年 | 86篇 |
2003年 | 76篇 |
2002年 | 70篇 |
2001年 | 40篇 |
2000年 | 44篇 |
1999年 | 41篇 |
1998年 | 41篇 |
1997年 | 33篇 |
1996年 | 26篇 |
1995年 | 36篇 |
1994年 | 23篇 |
1993年 | 14篇 |
1992年 | 45篇 |
1991年 | 40篇 |
1990年 | 45篇 |
1989年 | 45篇 |
1988年 | 43篇 |
1987年 | 26篇 |
1986年 | 38篇 |
1985年 | 39篇 |
1984年 | 26篇 |
1983年 | 24篇 |
1982年 | 12篇 |
1981年 | 14篇 |
1980年 | 18篇 |
1979年 | 24篇 |
1978年 | 21篇 |
1977年 | 18篇 |
1976年 | 11篇 |
1973年 | 12篇 |
1972年 | 9篇 |
1971年 | 9篇 |
1970年 | 8篇 |
排序方式: 共有1706条查询结果,搜索用时 31 毫秒
1.
Tauseef Ahmed Alan Yagoda Howard I. Scher Cora Sternberg Robin C. Watson 《Investigational new drugs》1986,4(2):171-174
Summary Deaza-aminopterin is a folate analog which is transported more rapidly than methotrexate into cells and appears to be more active than methotrexate against human and animal tumor in vitro. Fifteen patients with advanced urothelial tract cancer were given deaza-aminopterin 30–37.5 mg/m2 IV QW. In responding patients drug was given QOW after 4–6 consecutive doses. Doses were escalated or de-escalated by 7.5 mg/m2 depending on toxicity. Twelve patients had received prior chemotherapy which included methotrexate in nine. Three patients achieved a partial remission lasting 1, 3, and 3 months respectively: all responders had previously failed methotrexate after an initial response to a methotrexate containing regimen. None of the six patients who were methotrexate naive responded to deaza-aminopterin; 3 subsequently received methotrexate without response. Mild mucositis was universal and in 5 was severe. Six patients had an increase in liver transaminases probably secondary to anti-folate hepatotoxicity. Other toxicities included diarrhea, nausea, skin rash and fever. Further studies are needed to define the precise efficacy of deaza-aminopterin in patients with urothelial tract cancers. 相似文献
2.
3.
Robert Motzer Howard Scher Dean Bajorin Cora Sternberg George J. Bosl 《Investigational new drugs》1990,8(4):391-392
Summary Twenty-three patients with advanced renal cell cancer were treated with Didemnin B. One partial response was achieved (5%) in 21 evaluable patients. An allergic reaction was noted in four patients including one patient with anaphylaxis. Didemnin B is not recommended in the treatment of renal cell carcinoma. 相似文献
4.
5.
The first 150 words of the full text of this article appear below. Key points Coronary artery disease accounts for >30% ofdeaths in Western society. The diagnosis of myocardial infarctionshould be qualified by size, causation and time from occurrence. Mortalityis reduced by immediate or primary percutaneouscoronary intervention or thrombolysis within the first 24 hof onset of ST-segment elevation myocardial infarction. Strategiesto reduce platelet activation (glycoprotein IIb/IIIa receptorantagonists, or clopidogrel) are now recommended in the treatmentof high-risk non-ST-segment myocardial infarction/unstable angina. Elevatedserum troponins may be the result of non-ischaemic myocardialdamage, especially in critical illness.
Pathophysiology
Changes in the definition of terms relating to the diagnosisof myocardial infarction (MI) have evolved by better understandingof the pathophysiology culminating in the new term of acutecoronary syndrome (ACS). Figure 1 illustrates the processesthat occur in the development of an acute coronary event. 相似文献
6.
Mark S. Scher Marisha Y. Hamid Doris A. Steppe Marquita E. Beggarly Michael J. Painter 《Epilepsia》1993,34(2):284-288
Summary: The effect of gestational age on neonatal ictal and interictal durations has not been investigated. Sixty-eight neonates with 644 electrographic seizures were identified retrospectively. Thirty-five full-term (FT) neonates were compared with 33 preterm (PT) neonates. Eighteen older preterm infants (OPT) [>31 weeks estimated gestational age (EGA)] were also compared with 15 young preterm infants (YPT) of ≤31 weeks EGA. Ictal/ interictal durations were calculated for the total cohort with and without status epilepticus (SE). Statistical analyses were two-tailed t tests, chi-square calculations, and one-way analysis of variance (ANOVA) with Duncan's multiple-range test. Eleven of 35 (33%) FT had SE as compared with 3 of 33 (9%) PT (chi-square = 7.8, p < 0.05). The mean ictal duration was 14.2 min for FT infants as compared with 3.1 min for PT infants (p < 0.01); only borderline differences were noted after those with SE were excluded. Interictal durations were longer for OPT than YPT (p < 0.05). By ANOVA and Duncan's multiple-range tests, group differences included longer mean ictal durations for FT infants as compared with OPT infants (p = 0.06, ANOVA; p < 0.05, Duncan's), and longer mean interictal durations for FT infants versus OPT and OPT versus YPT (p = 0.02, ANOVA; p < 0.05, Duncan's). More developed neuronal networks result in longer ictal durations in FT than in PT neonates, including FT infants with SE. Inhibitory networks responsible for longer interictal periods are more dominant in OPT infants than in YPT infants, reflecting maturational changes that suppress seizure activity during the latter part of the third trimester before the infant reaches an FT corrected age. 相似文献
7.
8.
Complications of biliary surgery 总被引:4,自引:0,他引:4
Procedures on the gallbladder and extrahepatic biliary tract were the most frequently performed operations in a series of 1500 consecutive abdominal operations done in community hospitals. The operative mortality rate for elective cholecystectomy was 0.3 per cent. The complication rate was 21.4 per cent for cholecystectomy. Patients requiring emergency cholecystectomy had significantly more urinary tract and intra-abdominal problems than those patients who underwent surgery electively. Operative cholangiography was performed during 20.3 per cent of the elective cholecystectomies. There were no biliary tract complications among the cholecystectomy patients who had cholangiography. When this study was not performed, 1.5 per cent of the patients had postoperative bile duct problems. Older surgeons (greater than 60 years of age) and high volume surgeons (greater than 300 cases/year) were significantly less likely to employ cholangiography. The mortality rate for elective common duct exploration was 4.4 per cent, with a complication rate of 60 per cent. There was a 13.3 per cent incidence of retained stones after choledochotomy, though this problem was readily managed by percutaneous extraction through the T-tube tract. Complex biliary tract procedures were performed electively without mortality, though the complication rate for these procedures was 35.3 per cent. Two-thirds of the patients undergoing complex biliary tract operations on an emergency basis died. Board certified general surgeons had the same mortality and complication rates for cholecystectomy as well as common bile duct exploration. Noncertified surgeons had significantly more intraabdominal complications after complex biliary tract procedures compared to their board certified colleagues. 相似文献
9.
Patricia Grabowski Hans Scherübl 《Journal of clinical oncology》2005,23(21):4795-6; author reply 4796-7
10.