全文获取类型
收费全文 | 97篇 |
免费 | 13篇 |
专业分类
儿科学 | 3篇 |
妇产科学 | 2篇 |
基础医学 | 7篇 |
口腔科学 | 5篇 |
临床医学 | 4篇 |
内科学 | 16篇 |
外科学 | 8篇 |
综合类 | 2篇 |
预防医学 | 5篇 |
眼科学 | 15篇 |
药学 | 42篇 |
肿瘤学 | 1篇 |
出版年
2023年 | 1篇 |
2022年 | 3篇 |
2021年 | 2篇 |
2020年 | 5篇 |
2019年 | 1篇 |
2018年 | 1篇 |
2016年 | 4篇 |
2015年 | 4篇 |
2014年 | 2篇 |
2013年 | 11篇 |
2012年 | 3篇 |
2011年 | 5篇 |
2010年 | 5篇 |
2008年 | 8篇 |
2007年 | 9篇 |
2006年 | 6篇 |
2005年 | 2篇 |
2004年 | 6篇 |
2003年 | 6篇 |
2002年 | 12篇 |
2001年 | 5篇 |
2000年 | 2篇 |
1999年 | 3篇 |
1998年 | 2篇 |
1984年 | 1篇 |
1977年 | 1篇 |
排序方式: 共有110条查询结果,搜索用时 0 毫秒
1.
2.
Suganya Kandeeban Kaustubh Kandale Porkodi Periyasamy Muna Bhende Pramod Bhende Sinnakaruppan Mathavan Sripriya Sarangapani 《Indian journal of ophthalmology》2022,70(7):2578
Purpose:Stickler syndrome is associated with the development of rhegmatogenous retinal detachment (RRD), and often presents with ocular, auditory, skeletal, and orofacial abnormalities. Molecular analysis has proven effective in diagnosis, confirmation and classification of the disease. We aimed to describe the utility of next-generation sequencing (NGS) in genetic analysis of four Indian families with suspected Stickler syndrome.Methods: The index cases presented with retinal detachment with family history. Genetic analysis in the index case was performed by next-generation sequencing of inherited retinal degeneration genes, and validated by Sanger sequencing followed by co-segregation analysis in the other family members.Results: Twenty patients were included for the genetic analysis (15 males and 5 females from four families). Clinical details were available for 15 patients (30 eyes). Fourteen eyes (11 patients) developed RRD. In the 16 eyes without RRD, 8 underwent barrage laser to lattice degeneration and 8 were under observation. Disease segregating heterozygous mutations with pathogenic/likely pathogenic effect was identified in COL2A1 (c.4318-1G>A, c.141G>A, c.1221+1G>A for 3 families) and COL11A1 (c.1737+1 G>A for 1 family) gene. In addition to the mutation in the COL2A1 gene, a pathogenic heterozygous variant associated with risk for arrhythmogenic right ventricular cardiomyopathy (ARVC) was identified in one member.Conclusion: NGS testing confirmed the presence of the causative gene for Stickler syndrome in the index case followed by evaluation of family members and confirmation of genetic and ocular findings. We believe that this may be the first such report of families with RRD from India. 相似文献
3.
Alcohol is a known hepatotoxic agent, which may exacerbate liver injury caused by other agents. The wide prevalence of alcohol use and abuse in society makes it an important cofactor in many other liver diseases. Examples of liver diseases that are significantly influenced by ingestion of alcohol include chronic viral hepatitis, disorders of iron overload, and obesity-related liver disease. 相似文献
4.
5.
Sundaramurthy Srilekha SelvaKumar Ambika Ching Jared Dharani Vidhya Sarangapani Sripriya Yu-Wai-Man Patrick 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2021,259(9):2461-2472
Graefe's Archive for Clinical and Experimental Ophthalmology - Leber hereditary optic neuropathy (LHON) is the most common primary mitochondrial DNA (mtDNA) disorder with the majority of... 相似文献
6.
7.
Abdominal Radiology - 相似文献
8.
9.
10.