全文获取类型
收费全文 | 2615篇 |
免费 | 175篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 171篇 |
妇产科学 | 31篇 |
基础医学 | 305篇 |
口腔科学 | 57篇 |
临床医学 | 275篇 |
内科学 | 547篇 |
皮肤病学 | 75篇 |
神经病学 | 253篇 |
特种医学 | 489篇 |
外科学 | 212篇 |
综合类 | 65篇 |
预防医学 | 112篇 |
眼科学 | 19篇 |
药学 | 115篇 |
中国医学 | 3篇 |
肿瘤学 | 74篇 |
出版年
2023年 | 13篇 |
2022年 | 9篇 |
2021年 | 22篇 |
2020年 | 25篇 |
2019年 | 33篇 |
2018年 | 44篇 |
2017年 | 36篇 |
2016年 | 43篇 |
2015年 | 47篇 |
2014年 | 57篇 |
2013年 | 101篇 |
2012年 | 83篇 |
2011年 | 84篇 |
2010年 | 99篇 |
2009年 | 84篇 |
2008年 | 83篇 |
2007年 | 78篇 |
2006年 | 77篇 |
2005年 | 67篇 |
2004年 | 51篇 |
2003年 | 50篇 |
2002年 | 61篇 |
2001年 | 36篇 |
2000年 | 56篇 |
1999年 | 43篇 |
1998年 | 140篇 |
1997年 | 128篇 |
1996年 | 132篇 |
1995年 | 98篇 |
1994年 | 76篇 |
1993年 | 88篇 |
1992年 | 36篇 |
1991年 | 38篇 |
1990年 | 33篇 |
1989年 | 74篇 |
1988年 | 53篇 |
1987年 | 71篇 |
1986年 | 61篇 |
1985年 | 57篇 |
1984年 | 33篇 |
1983年 | 46篇 |
1982年 | 41篇 |
1981年 | 26篇 |
1980年 | 40篇 |
1979年 | 19篇 |
1978年 | 21篇 |
1977年 | 21篇 |
1976年 | 26篇 |
1975年 | 28篇 |
1973年 | 11篇 |
排序方式: 共有2813条查询结果,搜索用时 31 毫秒
1.
P Rubinstein M Walker N Mollen C Carpenter S Beckerman N Suciu-Foca R McEvoy F Ginsberg-Fellner 《Diabetes》1990,39(9):1138-1143
The gene frequencies, haplotype relative risks, and zygotic assortments of HLA-DR in three ethnically defined samples of insulin-dependent diabetes mellitus (IDDM) patients were determined in a prospective family study. Although DR3 and DR4 were positively associated with IDDM in the probands of 123 northern European, 94 Ashkenazi Jewish, and 49 New York Hispanic families, significant excess of DR*3/4 heterozygotes was observed only among the probands from families of northern European ancestry. There was also a significant decrease in the frequency of Bw62,DR4 haplotypes derived by northern European patients from their mothers compared with their fathers. This difference, together with data reported in the literature, suggests that the expressivity of the susceptible genotype(s) in IDDM patients may be modified by protective maternal effects associated with Bw62,DR4 and probably other DR4 haplotypes. Samples of IDDM patients from populations with high frequencies of these modifiers should have different DR-gene frequencies contributed by fathers and mothers, capable of accounting for the observed Hardy-Weinberg disequilibrium. We postulate that, because the mechanism of action of these modifiers is distinct from that of the susceptibility gene, the difference must be considered in devising strategies for elucidation of the mode of inheritance of the disease and for understanding the molecular nature of the susceptibility. 相似文献
2.
3.
JA HYEON KU CHEOL KWAK SEUNG-JUNE OH EUNSIK LEE SANG EUN LEE JAE-SEUNG PAICK 《International journal of urology》2004,11(7):489-493
BACKGROUND: Our aims in the present study were to estimate the influences of pain and urinary symptoms on quality of life, and to determine which of these two variables has the most predictive power with respect to quality of life in young men with chronic prostatitis-like symptoms. METHODS: Chronic prostatitis-like symptoms were measured by the National Institutes of Health-Chronic Prostatitis Symptom Index. Of the 28,841 men aged 20 years who lived in the study community, 18,495 men (a response rate 64.1%) agreed to participate in the study. A total of 1057 men who complained of symptoms indicative of chronic prostatitis were included in the study. The influences of pain and urinary symptoms on quality of life were determined using logistic regression analysis. The receiver operating characteristic (ROC) curve was used to estimate the predictive ability of each of these variables with respect to quality of life. RESULTS: Results from multivariate analysis showed that both pain and urinary symptoms were associated with an increased likelihood of impaired quality of life, although pain contributed more to a reduced quality of life than urinary symptoms. Relative to men who experienced mild pain, men who experienced moderate pain had a 3.9-fold risk of poor quality of life (odds ratio [OR], 3.87; 95% confidence interval [CI], 2.86-5.23; P < 0.001) and those who experienced severe pain had a 15.7-fold risk of reduced quality of life (OR, 15.68; 95% CI, 6.59-37.35; P < 0.001). Moderate urinary symptoms were associated with a 1.4-fold risk of bother (OR, 1.41; 95% CI, 1.01-1.99; P < 0.001) and severe urinary symptoms were associated with 2.4-fold risk (OR, 2.39; 95% CI, 1.37-4.12; P < 0.001), relative to mild urinary symptoms. Comparison of the effects of pain and urinary symptoms showed that pain severity had the most predictive power for bother, quality of life, and quality-of-life impact. The areas under the ROC curves for bother, quality of life, and quality-of-life impact were 71.3%, 69.3% and 72.5%, respectively. CONCLUSION: Urinary symptoms and pain might be associated with an increased likelihood of impaired quality of life in young men with chronic prostatitis-like symptoms. In addition, our findings suggest that pain severity is the most influential variable for determining quality of life in this population. 相似文献
4.
5.
6.
7.
8.
9.
10.