One-year outcome of combination therapy with intravitreal anti-vascular endothelial growth factor and photodynamic therapy in patients with pachychoroid neovasculopathy

Graefe's Archive for Clinical and Experimental Ophthalmology - To identify the functional outcome and evaluate the morphologic changes of patients with pachychoroid neovasculopathy (PNV)...     

Variable response of subretinal hyperreflective material to anti-vascular endothelial growth factor classified with optical coherence tomography angiography

Graefe's Archive for Clinical and Experimental Ophthalmology - To evaluate the prognosis and response of neovascular age-related macular degeneration (AMD) to anti-vascular endothelial growth...     

Predicting retinal sensitivity using optical coherence tomography parameters in central serous chorioretinopathy

Graefe's Archive for Clinical and Experimental Ophthalmology - To predict changes in retinal sensitivity using optical coherence tomography (OCT) in eyes with central serous chorioretinopathy...     

Association of Near-Infrared and Short-Wavelength Autofluorescence With the Retinal Sensitivity in Eyes With Resolved Central Serous Chorioretinopathy

PurposeThe purpose of this study was to compare the results of near-infrared autofluorescence (NIRAF) and short-wavelength autofluorescence (SWAF) imaging of eyes with resolved central serous chorioretinopathy (CSC) and to assess the retinal sensitivity (RS) in areas with abnormal autofluorescence (AF) using white-on-white (WW) and blue-on-yellow (BY) perimetries.MethodsWe examined 20 consecutive eyes with resolved CSC. We calculated the areas of abnormal AF detected by SWAF and NIRAF imaging as SWAF_area and NIRAF_area, respectively, and the number of measurement points within and outside abnormal SWAF and NIRAF regions were counted. The results of WW and BY perimetries were superimposed on the AF images, and the mean overall RS within and outside abnormal SWAF and NIRAF regions were calculated using both WW and BY perimetries (W-RSin_SWAF, W-RSout_SWAF, W-RSin_NIRAF, W-RSout_NIRAF, B-RSin_SWAF, B-RSout_SWAF, B-RSin_NIRAF, and B-RSout_NIRAF, respectively).ResultsThe mean age of the participants was 54.1 years. The SWAF_area was significantly smaller than the NIRAF_area (P < 0.0001, Wilcoxon signed rank test). A χ² test suggested a significant relationship between the number of measurement points within/outside abnormal SWAF and NIRAF regions (P < 0.0001). In the results of measurement by WW perimetry, there was a significant difference between W-RSin_NIRAF and W-RSout_NIRAF (P < 0.0001), but not between W-RSin_SWAF and W-RSout_SWAF (P = 0.060, Wilcoxon rank sum test). In contrast, on BY perimetry, there were significant differences between both B-RSin_SWAF and B-RSout_SWAF and between B-RSin_NIRAF and B-RSout_NIRAF (P < 0.0001).ConclusionsNIRAF was useful for predicting impaired RS in eyes with resolved CSC.     

Relationship between the vessel density around the optic nerve head and visual field deterioration in eyes with retinitis pigmentosa

Graefe's Archive for Clinical and Experimental Ophthalmology - To analyze the vessel density around the optic nerve head (ONH) by optical coherence tomography angiography (OCTA) in patients...     

Relationship Between Optical Coherence Tomography Parameter and Visual Function in Eyes With Epiretinal Membrane

PurposeTo investigate the associations between visual function and the optical coherence tomography (OCT) parameters in eyes with idiopathic epiretinal membrane (ERM).MethodsThirty-nine consecutive eyes with ERM were enrolled. In addition to OCT parameters, such as central retinal thickness (CRT), the area of gap between the ERM and the retinal surface (SUKIMA) was newly defined and calculated from the vertical and horizontal OCT images (SUKIMAv and SUKIMAh). The average of SUKIMAv and SUKIMAh (SUKIMAave) was used for the statistical analysis. The vertical and horizontal metamorphopsia scores (MV, MH) and the average of MV and MH (Mave) were also used for the analysis.ResultsThe Mave was not significantly associated with logMAR visual acuity (VA) (P = 0.57, linear regression analysis). Analysis using second-order bias-corrected Akaike information criterion model selection identified the age, CRT, and SUKIMAave as being associated with logMAR VA. On the other hand, among the OCT parameters, SUKIMAave and CRT were associated with the Mave. In addition, there was a significant relationship between SUKIMAh and MV (P = 0.011) and between SUKIMAv and MH (P = 0.0014).ConclusionsWe identified SUKIMA as a novel OCT parameter that is useful to predict both VA and metamorphopsia in patients with ERM.     

Optical coherence tomography characteristics of taxane-induced macular edema and other multimodal imaging findings

Graefe's Archive for Clinical and Experimental Ophthalmology - To identify common optical coherence tomography (OCT) characteristics of taxane-related CME (T-CME) to differentiate it from CME...