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RYOICHI INABA M.D. MANABU MAEDA M.D. SETSUYA FUJITA M.D. NAOKO KASHIKI B.S. YOKO KOMURA M.D. CHISATO NAGATA M.D. HIDHYO YOSHIDA M.D. SEYED MOHAMMAD MIRBOD Ph .D. HIROTOSHI IWATA M.D. YUKIKO SHIKANO M.D. YOSHIRO ICHIKI M.D. SHUNJI MORI M.D. 《International journal of dermatology》1993,32(9):652-655
Background. In order to evaluate the prevalence rates of Raynaud's phenomenon (RP) and specific clinical signs related to progressive systemic sclerosis (PSS) in the general population of Japan, inquiries were made concerning RP in the hands and dermatologic examinations were also conducted. Methods. One thousand and sixty-three subjects (332 men and 731 women) over 30 years of age who underwent inhabitants' health examinations in 1990 were considered for this study. Results. The prevalence of RP was 3.0% in men and 3.4% in women. In 8 men and 17 women with RP who received the blood tests, the positive rates of antinuclear antibody (ANA) were 12.5% and 35.3% in men and women, respectively. The prevalence rates of all five specific clinical signs related to PSS, sclerodactyly, pitting scars of the fingers, brown pigmentation of the body, shortened frenulum of the tongue, and flexion contracture of fingers, were under 2% in men and 3% in women. In women with RP the prevalence rates of sclerodactyly, pitting scars of the fingertips, brown pigmentation of the body, and shortened frenulum of the tongue were 16.0, 4.0, 4.0, and 16.0%, respectively. These values were significantly higher than those of persons without RP. Conclusions. Because some persons with primary RP may become typical cases of PSS within several years, a follow-up study, particulary for women who have positive titers of ANA with RP, should be carried out to find out whether the persons suffer from PSS or not. 相似文献
3.
MANABU OGISO MAKOTO TAKEHANA SHIZUKO KOBAYASHI MOTONORI HOSHI 《Experimental eye research》1998,66(6):765-773
Monkey and human lenses contain essentially the same glycosphingolipids, and Lewisxand sialylated Lewisxepitopes are expressed on the terminal structure of neolactotetraosylceramide. However, monolayer cultures of lens epithelial cells from rhesus monkey expressed gangliosides GM3, GD3 and a small amount of GM1, but not sialylated Lewisxepitopes. Eight-week-old cultures on various extracellular matrices resulted in morphological changes in lens epithelial cells. Monolayer of cells cultured on vitronectin or polylysine assembled into aggregates after 4 weeks of culture. Cells cultured on vitronectin expressed sialyl-Lewisxgangliosides and did not exhibit GD3. On collagens, fibronectin and laminin elongated cells were observed in cells cultured for 8 weeks. Thus, the interaction between cells and extracellular matrices influenced morphology and glycosphingolipid composition in lens epithelial cells. 相似文献
4.
Hepatic HCV-RNA as a predictor of outcome after interferon therapy in patients with chronic hepatitis C 总被引:2,自引:0,他引:2
MASAAKI KONDO KATSUAKI TANAKA MASANORI IKEDA SHINJU ARATA SATORU SAITO TAKASHI SAKAGUCHI MANABU MORIMOTO TAKANDO FUJII KONOMI MITSUI HIROSHI OKAZAKI MASATO HOSHINO HISAHIKO SEKIHARA 《Journal of gastroenterology and hepatology》1996,11(3):236-240
Measurement of serum HCV-RNA is a useful index for evaluating the antiviral effect of interferon therapy in chronic hepatitis C. In the present study, we investigated whether the detection of hepatic HCV-RNA after interferon treatment, using a polymerase chain reaction assay, predicted long-term response to therapy in patients with chronic hepatitis C. Thirty-three patients underwent liver biopsies before and after interferon therapy. Histology and clinical courses were compared after treatment. Before therapy, serum and hepatic HCV-RNA was detected in specimens from 32 (97%) and 33 (100%) patients, respectively. Serum HCV-RNA became undetectable in samples from 22 (67%) patients; however, in 10 of these patients (45%), serum HCV-RNA levels relapsed after therapy. Hepatic HCV-RNA became undetectable in 14 patients after therapy and the serum aminotransferase concentration remained within normal limits during and following (24–92 weeks) therapy in 12 of these patients (86%). All 11 patients with detectable hepatic HCV-RNA also had serum HCV-RNA and elevated aminotransferase concentrations refractory to therapy. The absence of hepatic HCV-RNA at the end of interferon treatment thus predicted a long-term complete response to therapy with a sensitivity of 100%, a specificity of 90% and an accuracy of 94%. We conclude that hepatic rather than serum HCV-RNA is a more useful index for the prediction of the long-term efficacy of interferon therapy. 相似文献
5.
TAKENOBU KAMADA M.D. HIDEYUKI FUSAMOTO M.D. MANABU MASUZAWA M.D. KOITCHI HIRAMATSU M.D. OSAMU FUKUI M.D. † 《The American journal of gastroenterology》1975,63(6):486-489
The clinical, endoscopic and histological findings of 14 cases with unusual gigantic ulcers of the stomach were reported. The patients were mainly aged, complicated by cardiovascular diseases. The ulcer was designated as "trench ulcer" from the characteristic endoscopic features, which ran from the cardiac portion to the angle along the lesser curvature. 相似文献
6.
NAOMI MIZUTANI M.D. YASUHIKO MASUDA M.D. NARIAKI NAITO M.D. TAKASHI TODA M.D. EI-ICHIRO YAO M.D. MANABU FUKUMOTO M.D. † 《The American journal of gastroenterology》1981,76(2):141-144
A 39-year old woman, with a pancreatic arteriovenous malformation (AVM) which ruptured into the pancreatic duct, was treated successfully with distal pancreatectomy and splenectomy. Histological examinations revealed an AVM with extravasation into the pancreatic ducts. A review of the cases reported to date emphasizes the importance of physical signs, individual histories and angiographic studies for early diagnosis and surgery. 相似文献
7.
Small renal oncocytoma with central cystic degeneration 总被引:4,自引:0,他引:4
KOICHI KODAMA KEN-ICHI NAGANO MANABU AKIMOTO SHIOTO SUZUKI 《International journal of urology》2004,11(2):110-113
A case of a small renal oncocytoma with central cystic degeneration, 15 mm in diameter, is reported. Contrast-enhanced computed tomography showed the tumor contained a central hypoattenuating region and had an irregular, heterogeneously enhanced wall. Magnetic resonance images showed a well-circumscribed lesion and the T(1)-weighted image indicated medium signal intensity, whereas the T(2)-weighted image indicated slight hypointensity. Both T(1)- and T(2)-weighted images showed central hyperintensity. Our preoperative diagnosis was renal cell carcinoma originating in a renal cyst wall or cystic renal cell carcinoma. Nephrectomy was performed because frozen-section examination did not completely rule out malignancy. The final pathological diagnosis of the entire surgical specimen was renal oncocytoma with cystic degeneration. To our knowledge, this is the 14th case of renal oncocytoma with central cystic degeneration reported in the published works. We discuss herein the variant forms of oncocytoma and difficulties with their preoperative diagnosis, especially when the tumor is small. 相似文献
8.
MANABU TAKITA TAKANOBU TANIGUCHI JUN ZHU IKUNOBU MURAMATSU 《The Journal of pharmacy and pharmacology》1997,49(8):802-805
The effects of chronic treatment with prazosin and of immobilization stress on the α1-adrenoceptor subtypes in rat cerebral cortex have been examined. Prazosin-treated rats were allowed free access to tap water containing two different concentrations of prazosin (16 or 156 mg L?) for 5 weeks. The mean plasma concentrations of prazosin were 5 ng mL? in groups treated with a low dose and 8 or 14 ng mL? in those treated with a high dose. Immobilization stress (2 h day?, 2 weeks) or chronic treatment with a low dose of prazosin caused no significant change in the affinity for [3H]prazosin or in the maximum number of α1-adrenoceptor sites (Bmax). However, treatment with prazosin (low dose) combined with stress increased the density of α1-adrenoceptors with low affinity for prazosin. Treatment with a high dose of prazosin increased the density of α1L-adrenoceptors, irrespective of stress loading. The densities of α1A- and α1B-adrenoceptors with high affinity for prazosin were increased only after treatment with a high dose of prazosin in combination with stress. These results indicate that three distinct α1-adrenoceptor subtypes, α1A, α1B and α1L, might be affected differently by treatment with prazosin and by stress. 相似文献
9.
AKITO HISANAGA MD MANABU TSUTSUMI MD PhD SHINICHI YASUI MD PhD HIDEMICHI FUKUDA MD PhD HIROYUKI TACHIBANA MD HIROFUMI HAGINO PhD AKIHITO OKABE MD TATSUO MITA MD OSAMU SAITOH MD PhD MASAYOSHI KURACHI MD PhD 《Psychiatry and clinical neurosciences》1998,52(2):206-207
Abstract We report a patient, a 30-year-old male Japanese-Brazilian migrant construction worker, suffering from excessive daytime sleepiness for at least 6 months. Electroencephalogram recordings during his waking states showed that 10-Hz and 60-µV alpha activity was present prominently in the occipital regions. From the multiple sleep latency test, it was found that stages 1–2 NREM sleep episodes appeared repetitively without any REM episodes, and that the mean sleep latency was 10.2 min. These findings support the diagnosis that this patient suffers from subwakefulness syndrome. 相似文献
10.
The Autonomic Control of the Transmural Dispersion of Ventricular Repolarization in Anesthetized Dogs 总被引:4,自引:0,他引:4
MANABU TAKEI M.D. YASUYUKI SASAKI M.D. TAKANORI YONEZAWA M.D. MANOJ LAKHE M.D. MASAKAZU ARUGA M.D. KENDO KIYOSAWA M.D. 《Journal of cardiovascular electrophysiology》1999,10(7):981-989
INTRODUCTION: The initiation of ventricular arrhythmias is in part associated with autonomic nervous tone. We investigated the effects of sympathetic and parasympathetic stimulation on the monophasic action potentials (MAPs) of the epicardium (EPi), mid-myocardial (M) region, and endocardium (Endo) in vivo. METHODS AND RESULTS: In 12 mongrel open chest anesthetized dogs, both sides of the cervical vagus nerves and stellate ganglia were crushed with a tight ligature. Right atrial pacing at 600 msec cycle length was begun after the sinus nodal area had been crushed. MAPs from the M region were measured by two needle electrodes that were supported by a W-shaped plastic frame. The epicardial, M region, and endocardial MAP durations at 90% repolarization (MAPD90) were 287+/-7, 315+/-7, and 290+/-8 msec, respectively. The MAPD90 from M cells was longer than that from Epi or Endo. Sympathetic stimulation shortened MAPD90 more in the M region (53+/-4 msec) than that in the Epi (27+/-3 msec) or Endo (26+/-4 msec). The transmural dispersion of repolarization during sympathetic stimulation was shorter than that of the control. Parasympathetic stimulation did not significantly affect any of the MAPD90 values. Simultaneous sympathetic and parasympathetic stimulation produced changes not significantly to those produced by sympathetic stimulation alone. CONCLUSION: Our results suggest that sympathetic activity can reduce transmural dispersion of repolarization under autonomic control in the canine heart under baseline conditions. 相似文献