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P R Lichter 《Ophthalmology》1992,99(6):843-844
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Carcinoma of the urethra (male and female) is an unusual disease with insufficient clinical experience to be dogmatic about therapeutic recommendations. The onset is usually insidious, with a long interval from the first symptoms to diagnosis, yet lack of local and regional control remains the principal obstacle to cure. Treatment choices and results depend to a great degree on the extent, location, and stage of the lesion. Our conclusion is that good surgery and carefully planned irradiation are equally effective in the management of these tumors. 相似文献
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Chromosome aberrations in B-cell chronic lymphocytic leukemia: reassessment based on molecular cytogenetic analysis 总被引:13,自引:0,他引:13
Döhner H Stilgenbauer S Döhner K Bentz M Lichter P 《Journal of molecular medicine (Berlin, Germany)》1999,77(2):266-281
In B-cell chronic lymphocytic leukemia (B-CLL) clonal chromosome aberrations are detected in approximately 40–50% of tumors
when using conventional chromosome banding analysis. Most studies find trisomy 12 to be the most frequent chromosome aberration,
followed by structural aberrations of the long arm of chromosomes 13 and 14. Trisomy 12 and the ”14q+” marker are associated
with shorter survival times, while the patients with 13q abnormalities have a favorable outcome, similar to those with a normal
karyotype. The development of molecular cytogenetic techniques has greatly improved our ability to detect chromosome aberrations
in tumor cells. Using fluorescence in situ hybridization, chromosome aberrations can be detected not only in dividing cells
but also in interphase nuclei, an approach referred to as interphase cytogenetics. The prevalence of specific aberrations in B-CLL is currently being reassessed by interphase cytogenetics. By far the most
frequent abnormality are deletions involving chromosome band 13q14, followed by deletions of the genomic region 11q22.3-q23.1,
trisomy 12, deletions of 6q21-q23, and deletions/mutations of the TP53 tumor suppressor gene at 17p13. The evaluation of the true incidence of these aberrations now provides the basis for more
accurate correlations with clinical characteristics and outcome. Deletions/mutations of the TP53 gene have been shown to be associated with resistance to treatment and to be an independent marker for poor survival. 11q
deletions have been associated with extensive nodal involvement, rapid disease progression, and short survival times. Whether
trisomy 12, 13q14, and 6q deletions have a prognostic impact awaits further study. The application of these molecular cytogenetic
techniques will also contribute to the identification of the pathogenetically relevant genes that are affected by the chromosome
aberrations in B-CLL.
Received: 2 February 1998 / Accepted: 31 March 1998 相似文献
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Cholecystokinin-decreased food intake in rhesus monkeys 总被引:1,自引:0,他引:1