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1.
Zeyu Li Erwei Hao Rui Cao Si Lin Linghui Zou Tianyan Huang Zhengcai Du Xiaotao Hou Jiagang Deng 《中草药(英文版)》2022,14(4):479-493
Zedoary tumeric (Curcumae Rhizoma, Ezhu in Chinese) has a long history of application and has great potential in the treatment of liver cancer. The anti liver cancer effect of zedoary tumeric depends on the combined action of multiple pharmacodynamic substances. In order to clarify the specific mechanism of zedoary tumeric against liver cancer, this paper first analyzes the mechanism of its single pharmacodynamic substance against liver cancer, and then verifies the joint anti liver cancer mechanism of its "pharmacodynamic group". By searching the research on the anti hepatoma effect of active components of zedoary tumeric in recent years, we found that pharmacodynamic substances, including curcumol, zedoarondiol, curcumenol, curzerenone, curdione, curcumin, germacrone, β-elemene, can act on multi-target and multi-channel to play an anti hepatoma role. For example, curcumin can regulate miR, GLO1, CD133, VEGF, YAP, LIN28B, GPR81, HCAR-1, P53 and PI3K/Akt/mTOR, HSP70/TLR4 and NF-κB. Wnt/TGF/EMT, Nrf2/Keap1, JAK/STAT and other pathways play an anti hepatoma role. Network pharmacological analysis showed that the core targets of the "pharmacodynamic group" for anti-life cancer are AKT1, EGFR, MAPK8, etc, and the core pathways are neuroactive live receiver interaction, nitrogen metabolism, HIF-1 signaling pathway, etc. At the same time, by comparing and analyzing the relationship between the specific mechanisms of pharmacodynamic substance and "pharmacodynamic group", it is found that they have great reference significance in target, pathway, biological function, determination of core pharmacodynamic components, formation of core target protein interaction, in-depth research of single pharmacodynamic substance, increasing curative effect and so on. By analyzing the internal mechanism of zedoary tumeric pharmacodynamic substance and "pharmacodynamic group" in the treatment of liver cancer, this paper intends to provide some ideas and references for the deeper pharmacological research of zedoary tumeric and the relationship between pharmacodynamic substance and "pharmacodynamic group". 相似文献
2.
Xiangyu Piao Changkai Sun Zhe Jin Jing Yu Xiaodan Chang Xin Tang Hongmei Liu Peiyang Zhou 《中国神经再生研究》2007,2(9):540-543
BACKGROUND: The cerebral ischemia and ischemia/reperfusion animal models are used to simulate the human cerebrovascular diseases is one of the popular topics of neurological science recently. To study the pathophysiology, pathogenesis, prophylaxis and treatment of ischemic cerebrovascular diseases and to establish the ideal animal model that is the most similar to the human cerebral ischemia, are the topics that the people generally cared about.
OBJECTIVE: To evaluate the effects of aerocyst-blocking bilateral ascending pharyngeal artery on the establishment of cerebral ischemia models by using digital subtraction angiography (DSA), magnetic resonance diffusion-weighted imaging (DWI) and magnetic resonance perfusion-weighted imaging (PWI).
DESIGN: Repetitive measure animal experiment.
SETTING: Zhongshan Hospital Affiliated to Dalian University.
MATERIALS: The experiment was carried out in the Animal Laboratory (Provincial Laboratory), Zhongshan Hospital of Dalian Univeristy from January to May 2006. A total of 14 domestic piglets, of 6 months old, weighing 12–15 kg, of either gender, were selected from Animal Experimental Center, Dalian University. Multistar T.O.P digital subtraction angiography machine was provided by Siemens Company, German.
METHODS: Aerocyst-blocking bilateral ascending pharyngeal artery was used to establish cerebral ischemia models. And then, Multistar T.O.P. DSA was used for imaging of cerebral vessels before blocking, during blocking and at 0.5 and 2 hours after ischemia perfusion. GE Signa 1.5 T supraconduction magnetic resonance imaging was used for DWI examination; in addition, PWI was used based on focal sites and areas. Otherwise, magnetic resonance imaging (MRI) was used to detect signal changes of T1WI and T2WI in ischemic areas.
MAIN OUTCOME MEASURES: Analytic results of DSA, DWI, PWI and MRI.
RESULTS: All 14 experimental piglets were involved in the final analysis. ① DSA: The blood flow of bilateral ascending pharyngeal arteries and its branch were blocked at blocking phase, which restored 0.5 and 2 hours after reperfusion. ② DWI and PWI: There were no observable abnormalities in PWI and DWI at pre-blocking. Abnormal increased signals were found on both DWI and PWI at during and post-blocking. There were reduction in ADC and rCBF and delay in rTTP at all time points except pre-blocking. ③ MRI: There were no abnormal signals observable at any time of pre- and post-blocking in T1WI and T2WI.
CONCLUSION: It is feasible to establish this kind of animal experimental models, and it can simulate the ischemic state; meanwhile, the existence and extent can be showed directly by DSA, DWI, and PWI. 相似文献
3.
4.
Dongrun Tang Guoxiang Song Shimin Cui Lingen Chen Qingbin LiDepartment of Ophthalmology the Second Affiliated Hospital Tianjin Medical UniversityTianjin ChinaDepartment of Neurosurgery Tianjin Huan Hu Hospital 《眼科学报》1994,(3)
By digital subtraction angiography(DSA), the authors made observations on 108 normal ophthalmic arteries in 80 patients with regard to the origins, courses, branching, morphology and anastomoses of the vessels. The merits and demerits of DSA in observing the ophthalmic artery were discussed. Eye Science 1994; 10: 157- 162. 相似文献
5.
6.
Liu Wenen Tang Yin Wang Lange Tan Deming Xiangya Hospital Central South University Changsha 《中国现代医学杂志》2003,13(8):18-20
Extended -spectrum β -lactamases(ESBLs)aremainlyproducedbymembersofthefamilyEnter obacteriaceaewhichcanhydrolyzeβ -lactamantibi oticsincludingthethird - generationcephalosporinandaztreonam ,theESBLs- producingbacillishowedmedian -highresistancetoceftazidimeandaztreonamparticularly[1] .NowadaystheprevalenceofESBLs -producingstrainshavebeenreportedinmanyareasaroundtheworld[2 ] .ButthereisfewinformationabouttherelationshipbetweentheuseofantibioticandtheproductionofESBLs .Weperformedastud… 相似文献
7.
Tang Jian汤健 Wang Yu王瑜 Zkang Chenhui张晨晖 E. Costa Institute of Cardiovascular Research Beijing Medical University 《北京大学学报(医学版)》1994,(Z1)
THECLONINGOFNa ̄+/Ca ̄(2+)EXCHANGERGENEANDITSEXPRESSIONINBRAINISCHEMIATangJian汤健,WangYu王瑜,ZkangChenhui张晨晖,E.CostaInstituteofCar... 相似文献
8.
Tang De-ji汤德骥 Xu Ying-han徐英含 Dai Di戴迪 Han Yong-jian韩永坚Wang Bi-chang王必瑺 Lang Ya-min郎亚民and Liang Yi梁毅Department of Hematology Pathology ZhejiangMedical University HangzhouZeng Yi曾毅Institute of Virology Chinese Academy of Preventive Medicine Beijing 《中华医学杂志(英文版)》1989,102(11):819-824
Human immunodeficiency virus (HIV) is now considered as the causative agent of acquired immunodeficiency syndrome (AIDS). A high risk of AIDS has been reported among patients with hemophilia who received lyophilized commercial factor VIII and IX concentrates of American origin. At a prevalent survey from September to December 1985, HIV antibodies were found in all four patients with hemophilia treated with the batch number W87307, 955 I.U. of American commercial factor VIII concentrate supplied by Armour Pharmaceutical Company, USA. One of the sero-positive patients developed AIDS-related complex (ARC) and died of cerebral hemorrhage. The other three sero-positive patients had abnormalities in cell-mediated immunity. Of them two developed left lumbosacral radiculopathy and hemorrhagic herpes zoster and one remained well so far. 相似文献
9.
Tang Su-en唐素恩 Kang Ying-qu康映蕖Departments of Pathology Obstetrics Gynecology First Hospital. Beijing Medical University Beijing. 《中华医学杂志(英文版)》1986,99(6):464-469
Eight cases of malignant and 12 0f benign Bren-
ner tumor are reported, patient ages ranged 31
69 and 39-53 years. The malignant tumor was
bilateral in 6 0f 8 cases, and the benign in l of 12.
The greatest diameter of the malignant tumors
averaged around 11 cm, and the benign 10. Six of
the malignant Brenner tumor patients died, one was
lost to follow up, and one survived for 10 years.
Pathologic and microscopic findings were pre-
sented in some detail. Based on the analysis of the
association between the histologic features and type
of Mullerian epithelium, we believe that the so called
Brenner tumor is in effect a tumor arising from the
Mullerian epithelium with a tendency to differentiate
into vaginocervical type epithelium. 相似文献
10.
LIU Qi JIA YuChen TIAN JianMing WANG ZhenTang YE Hua YANG JiJin SUN Fei 《World journal of gastroenterology : WJG》1997,(4)
AcomparativestudyofdiferentinterventionaltherapiesforprimarylivercancerLIUQi,JIAYuChen,TIANJianMing,WANGZhenTang,YEHua,YA... 相似文献