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1.
2.
Screening for complement deficiency in bacterial meningitis 总被引:1,自引:0,他引:1
T Ernst PJ Späth C Aebi UB Schaad MG Bianchetti 《Acta paediatrica (Oslo, Norway : 1992)》1997,86(9):1009-1010
Seventy-seven children with bacterial meningitis were screened for complement deficiency. Both the classical and the alternate pathways were normal in 75 patients. Transiently reduced total haemolytic activity of the classical pathway was documented in a boy with meningococcal meningitis. Total haemolytic activity of both the classical and the alternate pathways were reduced in another patient with pneumococcal meningitis: individual complement components determination indicated predominant activation of the alternate pathway. 相似文献
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5.
Citrate-mediated increase in the uptake of weathered 2,2-bis(p-chlorophenyl) 1,1-dichloroethylene residues by plants 总被引:1,自引:0,他引:1
Experiments were conducted to determine the ability of citrate to enhance the plant uptake of weathered 2,2-bis(p-chlorophenyl)1,1-dichloroethylene (p,p'-DDE) from soil. Plots containing three rows of clover, mustard, hairy vetch, or rye grass were constructed in soils containing p,p'-DDE. On 11 occasions, the rows of each crop received water or sodium citrate (0.005 or 0.05 M). For each crop, there were significant reductions in p,p'-DDE concentration in the soil fractions (near root and rhizosphere) closely associated with the plant versus bulk soil. The roots of each crop accumulated 2 to 5 times more of the weathered contaminant (dry wt) than present in the bulk soil. Citrate (0.05 M) increased the concentration of p,p'-DDE in the roots of clover, mustard, and hairy vetch by 39% compared with vegetation that received water. In batch desorption studies, the release of weathered p,p'-DDE was significantly greater in the presence of 0.05 M citrate than in water. Citrate increased the extracted aqueous concentrations of five metal ions (Al, Fe, Ca, K, Mn) from soil by five- to 23-fold over distilled water. We hypothesize that citrate physically disrupts the soil through chelation of structural metal ions and release of bound humic material, facilitating p,p'-DDE availability and uptake by plants. 相似文献
6.
The metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-
tetrakisphosphate in homogenates and sub-fractions from normal rat liver
and premalignant liver nodules was investigated. The activities of
5-phosphatase, expressed as pmol converted substrate per minute and mg
protein, were equal when using the two substrates, and did not differ
between normal and nodular homogenates. Subcellular fractions were purified
by sequential steps of differential centrifugation and density gradient
fractionation procedures. The total phosphatase activity was found to be
distributed between cytosol (15%) and membraneous fractions (75%), with
most of the enzyme activity residing in the plasma membranes. A doubling of
phosphatase specific activity was seen in the nodular low density membrane
fraction, containing Golgi apparatus and endosomes, as compared with normal
liver. Inositol 1,4,5- trisphosphate 3-kinase activity was found to be
exclusively cytosolic. No difference in this enzyme was seen between the
two tissue types studied. Vasopressin (0.2 or 2 microM) had no effect
either on phosphatase or kinase activity. The compartmentalization of
inositol polyphosphate 5-phosphatase activity presents a possible
explanation of earlier findings that premalignant liver tissue was able to
respond with inositol 1,4,5-trisphosphate, but not inositol 1,3,4,5-
tetrakisphosphate formation after agonist stimulation.
相似文献
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Treatment of meningitis due to methicillin-resistant Staphylococcus epidermidis with linezolid
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Krueger WA Kottler B Will BE Heininger A Guggenberger H Unertl KE 《Journal of clinical microbiology》2004,42(2):929-932
Methicillin-resistant Staphylococcus epidermidis (MRSE) can cause nosocomial meningitis in the presence of prosthetic devices. Vancomycin is the treatment of choice, but its penetration into the cerebrospinal fluid is poor, especially in cases without severe meningeal inflammation. We successfully used linezolid to treat a case of posttraumatic MRSE meningitis with a low-level inflammatory response. Therapeutic effectiveness was documented microbiologically and by the simultaneous measurement of linezolid levels in serum and cerebrospinal fluid. 相似文献
9.
Kottler UB Conway RM Schlötzer-Schrehardt U Holbach LM 《Orbit (Amsterdam, Netherlands)》2004,23(1):59-64
Isolated orbital neurofibroma (INO) without systemic neurofibromatosis is rare. Previous reports including MRI with elaboration of the ultrastructural features of the cellular and extracellular components in INO do not exist. A 44-year-old male presented with painless, slowly progressive proptosis (6 mm) and downward displacement (3 mm) of the left eye of two years duration. MRI revealed a suprabulbar mass hypointense to fat, isointense to brain on T1-weighted images with small hyperintense areas following contrast enhancement. T2-weighted images showed a predominantly hyperintense mass with a few hypointense islands. The lesion was excised using an anterior superior transseptal orbitotomy. Histopathologically, large areas of a paucicellular myxoid stroma containing mucopolysaccharides made up approximately three-quarters of the mass. Focal hypercellular areas showed marked collagen deposition. Blood vessels were distributed at the periphery of the lesion and in association with nodules of nerve sheath cells. Ultrastructurally, perineural and fibroblast-like cells were loosely arranged in a myxoid stroma. Schwann cells were embedded in a dense collagenous matrix. Variable differentiation of Schwann cells, perineural cells and fibroblast-like cells associated with a more solid (collagenous) or loose (myxoid) extracellular matrix may determine the characteristic, though not specific, MRI features in isolated neurofibromas of the orbit. 相似文献
10.
Kottler UB Cursiefen C Holbach LM 《Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde》2003,217(1):76-78
Orbital involvement in multiple myeloma is unusual. We describe the case of a 60-year-old male who presented with left proptosis, reduced visual acuity, diplopia and progressing signs of globe indentation 2 months after chemotherapy for multiple myeloma. MRI showed a well-defined tumor filling the mediobasal part of the left orbit. Incisional biopsy and reduction of tumor mass were performed using an anterior transconjunctival orbitotomy. Histopathologic findings and further systemic examination confirmed the reactivation of the multiple myeloma. Proptosis, intraocular pressure and visual acuity improved following external beam radiation therapy of the left orbit and repeated systemic chemotherapy. Orbital involvement in multiple myeloma was the only sign of insufficient chemotherapy. 相似文献