全文获取类型
收费全文 | 14112篇 |
免费 | 3189篇 |
国内免费 | 273篇 |
专业分类
耳鼻咽喉 | 704篇 |
儿科学 | 359篇 |
妇产科学 | 269篇 |
基础医学 | 588篇 |
口腔科学 | 492篇 |
临床医学 | 2010篇 |
内科学 | 3392篇 |
皮肤病学 | 596篇 |
神经病学 | 1301篇 |
特种医学 | 613篇 |
外国民族医学 | 1篇 |
外科学 | 3489篇 |
综合类 | 160篇 |
现状与发展 | 2篇 |
预防医学 | 1107篇 |
眼科学 | 477篇 |
药学 | 566篇 |
中国医学 | 72篇 |
肿瘤学 | 1376篇 |
出版年
2024年 | 82篇 |
2023年 | 574篇 |
2022年 | 317篇 |
2021年 | 618篇 |
2020年 | 925篇 |
2019年 | 402篇 |
2018年 | 884篇 |
2017年 | 755篇 |
2016年 | 969篇 |
2015年 | 875篇 |
2014年 | 1173篇 |
2013年 | 1302篇 |
2012年 | 695篇 |
2011年 | 623篇 |
2010年 | 796篇 |
2009年 | 964篇 |
2008年 | 477篇 |
2007年 | 337篇 |
2006年 | 433篇 |
2005年 | 267篇 |
2004年 | 208篇 |
2003年 | 171篇 |
2002年 | 160篇 |
2001年 | 189篇 |
2000年 | 118篇 |
1999年 | 180篇 |
1998年 | 261篇 |
1997年 | 278篇 |
1996年 | 327篇 |
1995年 | 296篇 |
1994年 | 189篇 |
1993年 | 134篇 |
1992年 | 133篇 |
1991年 | 132篇 |
1990年 | 73篇 |
1989年 | 132篇 |
1988年 | 106篇 |
1987年 | 79篇 |
1986年 | 89篇 |
1985年 | 88篇 |
1984年 | 91篇 |
1983年 | 73篇 |
1982年 | 75篇 |
1981年 | 52篇 |
1980年 | 54篇 |
1979年 | 34篇 |
1978年 | 45篇 |
1977年 | 46篇 |
1975年 | 45篇 |
1972年 | 32篇 |
排序方式: 共有10000条查询结果,搜索用时 312 毫秒
1.
Md. Golzar Hossain Aneela Javed Sharmin Akter Sukumar Saha 《Journal of microbiology, immunology, and infection》2021,54(2):175-181
Coronavirus disease-19 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is now a pandemic threat. This virus is supposed to be spread by human to human transmission. Cellular angiotensin-converting enzyme 2 (ACE2) is the receptor of SARS-CoV-2 which is identical or similar in different species of animals such as pigs, ferrets, cats, orangutans, monkeys, and humans. Moreover, a recent study predicted that dogs might be secondary hosts during the evolution of SARS-CoV-2 from bat to human. Therefore, there is a possibility of spreading SARS-CoV-2 through domestic pets. There are now many reports of SARS-CoV-2 positive cases in dogs, cats, tigers, lion, and minks. Experimental data showed ferrets and cats are highly susceptible to SARS-CoV-2 as infected by virus inoculation and can transmit the virus directly or indirectly by droplets or airborne routes. Based on these natural infection reports and experimental data, whether the pets are responsible for SARS-CoV-2 spread to humans; needs to be deeply investigated. Humans showing clinical symptoms of respiratory infections have been undergoing for the COVID-19 diagnostic test but many infected people and few pets confirmed with SARS-CoV-2 remained asymptomatic. In this review, we summarize the natural cases of SARS-CoV-2 in animals with the latest researches conducted in this field. This review will be helpful to think insights of SARS-CoV-2 transmissions, spread, and demand for seroprevalence studies, especially in companion animals. 相似文献
2.
Kara S. Tanaka MD Veronica R. Andaya BA Steven W. Thorpe MD Kenneth R. Gundle MD James B. Hayden MD Yee-Cheen Duong MD Raffi S. Avedian MD David G. Mohler MD Lee J. Morse MD Melissa N. Zimel MD Richard J. O'Donnell MD Andrew Fang MD Robert Lor Randall MD Tina H. Tran BS Christin New BA Rosanna L. Wustrack MD other members of Study Group FORCE 《Journal of surgical oncology》2023,127(1):148-158
3.
4.
5.
6.
7.
Javed A. Shaik Nima Estharabadi Ronda S. Farah Maria K. Hordinsky 《Experimental dermatology》2020,29(10):1004-1011
Platelet α-granules release growth factors (GFs) that promote healing and tissue regeneration. Platelet-rich plasma (PRP) is shown to be beneficial in treating alopecia, and however, clinical response can be inconsistent. Due to several fold enrichment of platelets secreting large quantities of GFs following PRP injections, heterogeneity in amounts of GFs secreted by platelets may contribute to inconsistent clinical responses. Herein, we evaluated factors that could potentially contribute to heterogeneous secretion of GFs by platelets. We measured platelet secretion of transforming growth factor beta1 (TGFβ1), platelet-derived growth factor (PDGF-BB), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF2) in aliquots of de-identified PRP samples from female patients undergoing therapy in the hair disease clinic. Although secretion of GFs by platelets was comparable in PRP samples of patients with non-cicatricial and cicatricial alopecia, a Shapiro-Wilk test for normal distribution indicated significant variability across all patient samples. The amount of GF secreted by platelets was comparable when PRP prepared from two FDA-cleared devices with distinct techniques were compared. We provide evidence of platelets secreting heterogeneous amounts of GFs within each sample as high and low secretion of random factors could be simultaneously detected. These results suggest inherent heterogeneity in secretion of GFs by platelets in patient samples that are not influenced by the device used to prepare PRP. Since some GFs could have antagonistic effects on hair growth, a balance between amounts of growth promoting and inhibiting factors may be crucial in determining clinical response to PRP therapy. 相似文献
8.
9.
10.
BackgroundExcessive consumption of ethanol is known to activate the mTORC1 pathway and to enhance the Collapsin Response Mediator Protein-2 (CRMP-2) levels in the limbic region of brain. The latter helps in forming microtubule assembly that is linked to drug taking or addiction-like behavior in rodents. Therefore, in this study, we investigated the effect of lacosamide, an antiepileptic drug and a known CRMP-2 inhibitor, which binds to CRMP-2 and inhibits the formation of microtubule assembly, on ethanol-induced conditioned place preference (CPP) in mice.MethodsThe behavior of mice following ethanol addiction and withdrawal was assessed by performing different behavioral paradigms. Mice underwent ethanol-induced CPP training with alternate dose of ethanol (2 g/kg, po) and saline (10 ml/kg, po). The effect of lacosamide on the expression of ethanol-induced CPP and on ethanol withdrawal associated anxiety and depression-like behavior was evaluated. The effect of drug on locomotor activity was also assessed and hippocampal CRMP-2 levels were measured.ResultsEthanol-induced CPP was associated with enhanced CRMP-2 levels in the hippocampus. Lacosamide significantly reduced the expression of ethanol-induced CPP and alleviated the levels of hippocampal CRMP-2 but aggravated withdrawal-associated anxiety and depression in mice.ConclusionThe present study demonstrated the beneficial effect of lacosamide in attenuation of expression of ethanol induced conditioned place preference via reduction of hippocampal CRMP-2 level. These findings suggest that lacosamide may be investigated further for ethanol addiction but not for managing withdrawal. 相似文献