全文获取类型
收费全文 | 32668篇 |
免费 | 1639篇 |
国内免费 | 153篇 |
专业分类
耳鼻咽喉 | 426篇 |
儿科学 | 582篇 |
妇产科学 | 579篇 |
基础医学 | 4364篇 |
口腔科学 | 1208篇 |
临床医学 | 2578篇 |
内科学 | 7740篇 |
皮肤病学 | 806篇 |
神经病学 | 2423篇 |
特种医学 | 1290篇 |
外科学 | 5288篇 |
综合类 | 218篇 |
一般理论 | 3篇 |
预防医学 | 1048篇 |
眼科学 | 496篇 |
药学 | 2228篇 |
中国医学 | 48篇 |
肿瘤学 | 3135篇 |
出版年
2022年 | 301篇 |
2021年 | 648篇 |
2020年 | 315篇 |
2019年 | 453篇 |
2018年 | 620篇 |
2017年 | 451篇 |
2016年 | 491篇 |
2015年 | 571篇 |
2014年 | 772篇 |
2013年 | 839篇 |
2012年 | 1332篇 |
2011年 | 1438篇 |
2010年 | 788篇 |
2009年 | 733篇 |
2008年 | 1283篇 |
2007年 | 1346篇 |
2006年 | 1369篇 |
2005年 | 1401篇 |
2004年 | 1359篇 |
2003年 | 1295篇 |
2002年 | 1299篇 |
2001年 | 1221篇 |
2000年 | 1385篇 |
1999年 | 1198篇 |
1998年 | 393篇 |
1997年 | 280篇 |
1996年 | 296篇 |
1995年 | 274篇 |
1994年 | 238篇 |
1993年 | 225篇 |
1992年 | 796篇 |
1991年 | 752篇 |
1990年 | 678篇 |
1989年 | 695篇 |
1988年 | 676篇 |
1987年 | 663篇 |
1986年 | 673篇 |
1985年 | 594篇 |
1984年 | 429篇 |
1983年 | 352篇 |
1979年 | 340篇 |
1978年 | 232篇 |
1977年 | 199篇 |
1975年 | 198篇 |
1974年 | 226篇 |
1973年 | 207篇 |
1972年 | 197篇 |
1971年 | 209篇 |
1970年 | 203篇 |
1969年 | 224篇 |
排序方式: 共有10000条查询结果,搜索用时 187 毫秒
1.
2.
Toshihiro Yoshitake Akira Takeda Kensaku Ohki Yuko Inoue Takanori Yamawaki Saori Otsuka Minekatsu Akimoto Mitsuru Nemoto Yasuhito Shimakura Akio Sato 《The Journal of dermatology》2015,42(7):735-738
Finasteride is standard medical treatment for androgenetic alopecia; however, no large studies with 5 years or more of follow up have been performed in Japan. The authors followed Japanese men with androgenetic alopecia treated with finasteride for 5 years to evaluate long‐term treatment efficacy. Of 903 men treated with finasteride (1 mg/day), 801 patients were evaluated over 5 years by modified global photographic assessment. Although the proportion of improvement was high (99.4%), modified global photographic assessment scores after 5 years of treatment were lower in patients with more advanced disease as measured by the modified Norwood–Hamilton scale. After separating patients into “sufficient” and “insufficient” efficacy groups according to the modified global photographic assessment score after 5 years (scores ≥6 and <6, respectively), multivariate analysis showed that independent risk factors of insufficient efficacy were age at start of treatment of 40 years or more (P = 0.021) and classification on the modified Norwood–Hamilton scale (P < 0.001), whereas presence of stress at start of treatment was a negative predictor (P = 0.025). In conclusion, continuous finasteride treatment for 5 years improved androgenetic alopecia with sustained effect among Japanese. Younger age and less advanced disease at start of treatment were the key predictors of higher finasteride efficacy. 相似文献
3.
Mayuko Kinoshita Haruka Kaneko Lizu Liu Masashi Nagao Ryo Sadatsuki 《Modern rheumatology / the Japan Rheumatism Association》2019,29(1):157-164
Objectives: To examine the factors associated with increase in lumbar spine bone mineral density (LS-BMD) by bisphosphonates (BPs) with active vitamin D analog (aVD).Methods: Two independent postmenopausal osteoporotic patients treated by BPs with aVD for 24 months (Study 1: n?=?93, Study 2: n?=?99) were retrospectively analyzed.Results: In Study 1, LS-BMD of the patients significantly increased for 24 m (5.4%, p?.001). A multiple regression analysis among baseline characteristics revealed that serum calcium (sCa: 8.5–10.5?mg/dL) was associated with an increased LS-BMD by treatment (r2: 0.088, p?=?.02). While average sCa of the patients was 9.2?mg/dL before treatment, it increased time-dependently to 9.6?mg/dL for 24 m by treatment. As each patient had their LS-BMD five times during the study, there were four instances of %LS-BMD in each patient, resulting in 372 instances of %LS-BMD in Study 1. The smallest Akaike’s information criterion value for the most appropriate cut-off levels of sCa for %LS-BMD by treatment every 6 m was 9.3?mg/dL. The %LS-BMD by treatment for 6 m during 24 m period in patients with sCa ≥9.3?mg/dL (1.5%) was significantly higher than that in patients with sCa <9.3?mg/dL (0.8%, p?=?.038). The results of Study 2 were similar to those of Study 1, confirming the phenomena observed.Conclusion: sCa was associated with an increased LS-BMD by BPs with aVD. 相似文献
4.
5.
Marcelo Sato‐Sano Solange Pistori Teixeira Juliano Cordova Vargas Otvio Cesar Carvalho Guimares Baiocchi Milvia Maria Simes e Silva Enokihara Elimar Elias Gomes Mariana Dias Batista 《The Journal of dermatology》2019,46(7):618-621
Eosinophilic dermatosis of hematological malignancy is a paraneoplastic skin eruption associated with chronic lymphocytic leukemia and other B‐cell malignancies. It clinically resembles an insect bite reaction and it can precede the symptoms of the hematological malignancy or be related to a more aggressive course. Different treatments have been proposed, but partial response and recurrence are frequent. Herein, we describe a case of eosinophilic dermatosis associated with mantle cell lymphoma with remission after lenalidomide therapy. 相似文献
6.
Setsuyo Morimoto Keiko Hirano Keiko Tabata Haruka Asaumi Yuko Morikawa Yuki Matsumi Shuhei Naka Michiyo Matsumoto-Nakano 《Pediatric Dental Journal》2019,29(3):138-145
Early onset periodontitis is rarely seen in infants, though often leads to an acute and serious clinical course when encountered in such patients. Autoimmune neutropenia presents systemic and dental symptoms, as depressed resistance to bacterial infection is caused by a disorder that reduces the number of neutrophils. This disease can result in not only gingival inflammation but also destruction of periodontal tissues, such as attachment loss, alveolar bone absorption, and early tooth loss in primary as well as mixed dentition. Here, we report treatment of a child with marginal periodontitis from the age of 3 years–7 years 9 months. No systemic manifestations were noted until 3 years of age, thus the patient had never received a detailed examination or medication related to the disease. Following examinations at our department, we referred the patient to a pediatrician at our university hospital for possible systemic disease, who made a diagnosis of autoimmune neutropenia. Although administration of antibiotics and professional dental care were continued, neutrophil count was not increased and progressive periodontal destruction was observed. Extraction of teeth with poor prognosis was performed and a prosthetic strategy for the missing teeth developed. It is important to recognize that periodontitis along with autoimmune neutropenia can appear in infants, even though the incidence is quite low. Early detection and early treatment of this disease is necessary for delaying progression of periodontitis and optimal occlusal induction of permanent teeth. 相似文献
7.
8.
9.
Satoshi Iyama Yasuo Takahashi Naoaki Shintani Koshi Fujikawa Syunichi Ohkubo Yasushi Sato Tsutomu Sato Yasuhiro Sato Keisuke Ohnuma Yoshiro Niitsu 《Nihon Shokakibyo Gakkai zasshi》2006,103(10):1163-1168
We report a case of biliary cystadenocarcinoma which recurred 41 months postoperatively. A 60-year-old woman was admitted for further examination of multiple metastatic tumors and a large amount of ascites. Systemic administration of 5FU and CDDP caused her CEA level to decrease gradually and abdominal computed tomography revealed considerable reduction of the metastatic tumors and ascites. Since her general condition had improved, chemotherapy was continued in the outpatient clinic. 相似文献
10.
Kensaku Maeda Kenichi Yasunari Eisuke F Sato Junichi Yoshikawa Masayasu Inoue 《Hypertension research》2003,26(12):999-1006
The involvement of oxidative stress in polymorphonuclear leukocytes (PMN) in the pathogenesis of hypertension remains to be elucidated. We analyzed the generation of reactive oxygen species (ROS) by the circulating and peritoneally infiltrating PMN from spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY). Flow cytometric analysis revealed that ROS generation by PMN from SHR was higher than that from WKY before (at 6 weeks of age) and after (at 16 weeks of age) the onset of hypertension. In vivo, ROS generation by PMN from SHR, but not that by PMN from WKY, was significantly suppressed by 10-week treatment with 50 mg/kg/day carvedilol, and this treatment did not affect blood pressure. Western blotting analysis revealed that protein kinase C alpha (PKCalpha), but not PKCbetaI or betaII, was activated more strongly in PMN from SHR than in PMN from WKY. Furthermore, expression of p47phox of nicotinamide adenine dinucleotide phosphate oxidase, but not of p67phox, in PMN from SHR was higher than that in PMN from WKY. These results suggest that ROS generation by PMN is principally enhanced in SHR through activation of PKCalpha and p47phox. 相似文献