全文获取类型
收费全文 | 53篇 |
免费 | 3篇 |
专业分类
儿科学 | 2篇 |
基础医学 | 15篇 |
临床医学 | 7篇 |
内科学 | 4篇 |
皮肤病学 | 3篇 |
外国民族医学 | 1篇 |
外科学 | 3篇 |
综合类 | 2篇 |
眼科学 | 5篇 |
药学 | 12篇 |
肿瘤学 | 2篇 |
出版年
2023年 | 1篇 |
2022年 | 1篇 |
2021年 | 2篇 |
2020年 | 2篇 |
2018年 | 6篇 |
2017年 | 1篇 |
2016年 | 4篇 |
2015年 | 1篇 |
2014年 | 3篇 |
2013年 | 4篇 |
2012年 | 3篇 |
2011年 | 3篇 |
2010年 | 4篇 |
2009年 | 1篇 |
2008年 | 1篇 |
2007年 | 3篇 |
2006年 | 4篇 |
2005年 | 1篇 |
2004年 | 1篇 |
2003年 | 1篇 |
2002年 | 2篇 |
2000年 | 2篇 |
1994年 | 1篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1977年 | 1篇 |
排序方式: 共有56条查询结果,搜索用时 0 毫秒
1.
Kevin Brooks Hanem Hasan Sridhar Samineni Venu Gangur Wilfried Karmaus 《Pediatric allergy and immunology》2007,18(7):621-624
Placental p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) concentration and cord blood atopic markers were determined in 19 neonates. Increased placental p,p'-DDE was associated with a statistically significant increase in cord plasma interleukin (IL)-13. Furthermore, both cord plasma IL-4/interferon (IFN)-gamma and IL-13/IFN-gamma ratios were significantly positively associated with placental p,p'-DDE concentration. 相似文献
2.
观察25例骨髓增生异常综合征(MDS)和30例正常人外周血淋巴细胞微核。MDS患者外周血微核淋巴细胞出现率为84.00%,淋巴细胞微核率为6.68‰,显著高于对照组(P<0.005)。RAEB和RAEB-T亚型淋巴细胞微核率显著高于RA亚型(P<0.005)。MDS微核淋巴细胞多微核率与对照组差异无显著性(P>0.05)。同时检查外周血淋巴细胞染色体,MDS染色体畸变率为14.68%,显著高于对照组,且与微核率呈直线正相关(r=0.76,P0.001)。本文就MDS微核检测的意义进行了讨论。 相似文献
3.
Awad HM Boersma MG Boeren S van Bladeren PJ Vervoort J Rietjens IM 《Chemical research in toxicology》2002,15(3):343-351
In the present study, the formation of glutathionyl adducts from a series of 3',4'-dihydroxy flavonoid o-quinone/p-quinone methides was investigated with special emphasis on the regioselectivity of the glutathione addition as a function of pH. The flavonoid o-quinones were generated using horseradish peroxidase, and upon purification by HPLC, the glutathionyl adducts were identified by LC/MS as well as (1)H and (13)C NMR. The major pH effect observed for the glutathione conjugation of taxifolin and luteolin quinone is on the rate of taxifolin and luteolin conversion and, as a result, on the ratio of mono- to diglutathione adduct formation. With fisetin, 3,3',4'-trihydroxyflavone, and quercetin, decreasing the pH results in a pathway in which glutathionyl adduct formation occurs in the C ring of the flavonoid, being initiated by hydration of the quinone and H(2)O adduct formation also in the C ring of the flavonoid. With increasing pH, for fisetin and 3,3',4'-trihydroxyflavone glutathione adduct formation of the quinone occurs in the B ring at C2' as the preferential site. For quercetin, the adduct formation of its quinone/quinone methide shifts from the C ring at pH 3.5, to the A ring at pH 7.0, to the B ring at pH 9.5, indicating a significant influence of the pH and deprotonation state on the chemical electrophilic behavior of quercetin quinone/quinone methide. Together the results of the present study elucidate the mechanism of the pH-dependent electrophilic behavior of B ring catechol flavonoids, which appears more straightforward than previously foreseen. 相似文献
4.
5.
Background The larvae of Lucilia sericata induce myiasis and transmit mycobacterial infections to humans and animals. Consequently, the blowfly should be controlled for human welfare and economic reasons.
Methods The insecticidal effect of fenugreek ( Trigonella foenum-graecum ), celery ( Apium graveolens ), radish ( Raphanus sativus ), and mustard ( Brassica compestris ) against the third larval instars of L. sericata was evaluated, for the first time, through ingestion assays. The effect of sublethal concentrations on certain biological aspects, such as the pupation rates and adult emergence, was revealed.
Results The LC50 values were 2.81, 4.60, 6.93, and 7.92% for fenugreek, celery, radish, and mustard, respectively. The adverse effects on larval treatment also included the survival of pupae and adults. The pupation rate was strongly decreased after treatment with 16% fenugreek and celery. Moreover, adult emergence was suppressed after treatment of larvae with 8% mustard, 12% radish, and 16% fenugreek and celery oils. The number of emerged males exceeded the number of females, which could lead to population decline. Morphologic abnormalities of larvae, pupae, and adults were recorded after treatment with all tested oils.
Conclusion The results suggest that oils may represent new and safe potential insecticides for the control of blowflies. 相似文献
Methods The insecticidal effect of fenugreek ( Trigonella foenum-graecum ), celery ( Apium graveolens ), radish ( Raphanus sativus ), and mustard ( Brassica compestris ) against the third larval instars of L. sericata was evaluated, for the first time, through ingestion assays. The effect of sublethal concentrations on certain biological aspects, such as the pupation rates and adult emergence, was revealed.
Results The LC
Conclusion The results suggest that oils may represent new and safe potential insecticides for the control of blowflies. 相似文献
6.
7.
Sarah Alsubhi Amal Alhashem Eissa Faqeih Majid Alfadhel Abdullah Alfaifi Waleed Altuwaijri Saud Alsahli Hesham Aldhalaan Fowzan S. Alkuraya Khalid Hundallah Adel Mahmoud Ali Alasmari Fuad Al Mutairi Hanem Abduraouf Layan AlRasheed Saad Alshahwan Brahim Tabarki 《American journal of medical genetics. Part A》2017,173(10):2614-2621
8.
Increased Intracellular Potassium and Water Contents in Rat Heart after α-1-Adrenoceptor Stimulation
Sigrid Hanem Mette Enger Tor Skomedal Jan-Bjrn Osnes 《Basic & clinical pharmacology & toxicology》1994,75(5):294-301
Abstract: Potassium accumulation in rat heart after α-1-adrenoceptor stimulation has previously been reported from indirect measurements. Here we present data on intracellular potassium content measured directly in the heart. Isolated rat hearts perfused in a non-recirculating system were exposed to α-1-adrenoceptor stimulation (5 × 10-5 mol/1 phenylephrine in the presence of 10?6 mol/1 timolol). 14C-Sucrose was used to estimate the extracellular space. From heart homogenates intracellular potassium, magnesium and cellular water contents were determined and the ion concentrations calculated accordingly. The intracellular magnesium content remained unchanged during all experimental conditions. α-1-Adreno-ceptor stimulation evoked an increase in potassium content by 9% (4, 14; 95% confidence interval (CI), P=0.0006). Due to an observed increase in intracellular water by 17% (9, 26; 95% CI, P=0.0006), the potassium concentration apparently decreased by 8% (0.3, 15; 95% CI, P=0.04). During partial inhibition of the Na+/K+-ATPase by 10?5 mol/1 ouabain, there was an increase in potassium content by 5% (1, 9; 95% CI, P=0.008). There was, however, no significant increase in intracellular water in this situation. Calculated intracellular potassium concentration showed accordingly a slight increase. The effects upon potassium and water both in the absence and presence of ouabain were eliminated by the α-1-adrenocep-tor blocker prazosin (10?6 mol/1). α-1-Adrenoceptor stimulation apparently increased cellular dry weight by 10% (2, 18; 95% CI, P=0.02). Changes in translocation of potassium and water must be considered as part of the α-1-adrenergic heart effects. 相似文献
9.
Mohsen Saleh Elalfy Amira Adly Hanem Awad Mohamed Tarif Salam Vasilios Berdoukas Fernando Tricta 《American journal of hematology》2018,93(2):262-268
Iron overload is inevitable in patients who are transfusion dependent. In young children with transfusion‐dependent thalassemia (TDT), current practice is to delay the start of iron chelation therapy due to concerns over toxicities, which have been observed when deferoxamine was started too early. However, doing so may increase the risk of iron accumulation that will be manifested as toxicities later in life. This study investigated whether deferiprone, a chelator with a lower affinity for iron than deferoxamine, could postpone transfusional iron overload while maintaining a good safety profile. Recently diagnosed TDT infants (N = 64 their age ranged from 10 to 18 (median 12) months, 54.7% males; receiving ≤6 transfusions; serum ferittin (SF) >400 to < 1000 ng/mL were randomized to “early start deferiprone” (.ES‐DFP) at a low dose (50 mg/kg/day) or to “delay chelation” (DC), and remained in the study until their serum ferritin (SF) level reached ≥1000 μg/L. 61 patients continued the study Levels of transferrin saturation (TSAT) and labile plasma iron (LPI) were measured as well. By approximately 6 months postrandomization, 100% of the subjects in DC group had achieved SF > 1000 µg/L and TSAT > 70% compared with none in the ES‐DFP group. LPI level > 0.6 µM was observed in 97% vs. 40% of the DS and ES groups, respectively, (P < 0.001). The time to reach SF > 1000 µg/L was delayed by 6 months in the ES‐DFP group (P < 0.001) without escalating DFP dose. No unexpected, serious, or severe adverse events were seen in the ES‐DFP group. 相似文献
10.
Toxicity and growth inhibition potential of vetiver,cinnamon, and lavender essential oils and their blends against larvae of the sheep blowfly,Lucilia sericata 下载免费PDF全文