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1.
The composition of the clientele from an ophthalmological practitioner's office is described with special reference to the occurrence of glaucoma and disc haemorrhages (h in singular; hh in plural). This study could not be planned as an epidemiological survey and gives no clue to sensitivity or specificity of hh in glaucoma. During a period of about 10 years ending with 1986 there were 731 patients with h and/or glaucoma. When detected, 185 patients had h but no glaucoma, 33 had both h and glaucoma and 513 had glaucoma but no h. During the follow-up period hh were detected in 83 cases of glaucoma, and glaucoma developed in 27 cases with hh. The detection rate of hh among glaucoma was low but steady, indicating that hh may occur at any stage of the glaucoma process. This study shows no predilection for hh in cases with general hypertension or diabetes, nor is the frequency of hh among pseudoexfoliation cases significantly lower than among cases without this stigma. 相似文献
2.
OBJECTIVE: Failure after ileal pouch-anal anastomosis (IPAA) is reported with a frequency of 10-20%. The failed IPAA can be excised or defunctioned. Indications for excision and further management of an indefinitely diverted pouch are poorly described. The aim of the present investigation was to investigate pouch-related problems and the histopathological pattern of the pouch mucosa in this group of patients. METHOD: In a cohort of 620 patients having IPAA with a median follow-up of 14 years, 56 patients with failure were identified. The patients with defunctioned pouches were assessed with regard to pouch-related problems and endoscopy with biopsies was performed. Biopsies were stained with haematoxylin-eosin, PAS for neutral mucins and Alcian blue/high iron diamine for sialomucins/sulphomucins. Morphological changes were grouped into three types modified according to Veress and assessed for dysplasia. RESULTS: Twenty-two patients with an indefinitely diverted pouch were found. The follow-up time after surgery for failure was 10 years. Thirteen patients completed the follow-up. Except for two patients with pelvic/perineal pain, there were no clinical problems. The majority of patients displayed mild to moderate macroscopic signs of inflammation. Morphologically, findings ranged from a preserved mucosal pattern to intense inflammatory reaction. No case of dysplasia or carcinoma was found. CONCLUSION: Most patients with an indefinitely diverted pouch had no complaints regarding the pouch. There was no case of dysplasia. Indefinite diversion may be preferable to pouch excision, especially given the associated morbidity. 相似文献
3.
Bo Bengtsson 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1989,227(3):241-243
Intraocular pressures and optic disc hemorrhages were studied in all cases of manifest glaucoma detected in a defined population over a decade. High intraocular pressure was found to be an unreliable signat the detection of a glaucomatous visual field defect and an unusual finding 5–10 yearsbefore. The prevalence of optic disc hemorrhages at the detection of a glaucomatous visual field defect was 33%. All but 9 of 44 persons with manifest glaucoma were found to have had at least one optic disc hemorrhage at one time or another. 相似文献
4.
B E Bengtsson A Larsson A Bengtsson L Renberg 《Ecotoxicology and environmental safety》1988,15(1):62-71
The effects of tetrachloro-1,2-benzoquinone (TCQ), a component in bleached kraft mill effluents (BKME), on vertebral and physiological parameters were investigated in juvenile fourhorn sculpin, Myoxocephalus quadricornis L. After about 4.5 months of exposure to 0.1 and 0.5 mg TCQ/liter in 7% salinity brackish water, the fish demonstrated vertebral deformities, aberrant mechanical properties of the vertebrae, effects on white and red blood cell counts, enhanced activity of delta-aminolevulinic acid dehydratase in erythrocytes, and increased levels of ascorbic acid in the liver. The effects are discussed in relation to those previously observed in fish exposed to complex BKME in the field and the laboratory. 相似文献
5.
Göran Bengtsson Sten Rundgren 《Archives of environmental contamination and toxicology》1992,23(2):198-205
The influence of seasonal temperature variations and liming and acidification of the soil on lead uptake in juveniles and adults of the earthworm species Lumbricus terrestris L. was studied by enclosing specimens for up to five months in net bags provided with lead-contaminated, sandy soil. Lead concentrations were analyzed in the pharynx, gizzard, muscles, seminal vesicles and cerebral ganglion. Lead distribution in whole animals was assessed after an injection of 203Pb. The lead concentrations of the tissues were mostly linearly correlated with the soil concentrations, which ranged from <0.5 to 310 mg/kg, and the highest concentrations were generally found in the ganglion. The effects on lead concentrations in tissues of lowered soil pH from 5.6 to 5.1 or raised to 5.9 were insignificant, though more lead became allocated to muscles than to ganglion when pH was lowered. The lead uptake was strongly dependent on the ambient temperature, especially in the muscles, and the concentrations were reduced by 50% or more during the cold spell in the winter season, presumably as a consequence of a low feeding activity. Though juveniles seemed more prone to take up lead, the concentrations were not significantly higher than those in adults during the winter period. The observations are discussed in the light of the use of earthworms in standardized programs for environmental hazard assessment, especially with respect to species and tissue selection. 相似文献
6.
Staffan Eksborg Lennart Hardell Nils-Olof Bengtsson Marie Sjödin Birgitta Elfsson 《Medical oncology (Northwood, London, England)》1992,9(2):75-80
Sixty women with breast cancer (mean age: 61 years; range 36-78 years) were treated with Epirubicin (4’epi-Dox-orubicin),
60 mg m-2 , as single drug therapy. The drug was administered as 2 hours’ constant rate infusions. The pharmacokinetics of the drug
during the first course of treatment was evaluated by measurements of the plasma concentration of Epirubicin at the end of
the infusion period.
There was a five-fold inter-individual variation of the dose-normalized maximum plasma concentration, which increased with
increasing age of the patients. There was no correlation between this pharmacokinetic parameter and degree of obesity. 相似文献
7.
8.
B. Granstrm E. Nilsson U. Hultkvist‐Bengtsson L. Edvinsson 《Acta physiologica (Oxford, England)》2004,181(2):259-264
Aims and Methods: The pulmonary and vascular effects of endothelin‐1 receptor activation were studied in isolated perfused and ventilated lung preparations from rat. The responses to endothelin‐1 (ET‐1) and the endothelin B (ETB) receptor agonist sarafotoxin 6c (S6c) were characterized using the endothelin A (ETA)‐receptor antagonist FR 139317, the ETB‐receptor antagonist BQ 788 and the combined ETA/ETB‐receptor antagonist Bosentan. The respiratory parameter airway conductance (Gaw) and the vascular parameter perfusion flow were analysed simultaneously. Results: Concentration–response curves for ET‐1 administered intra‐arterially revealed that its most potent effect was on the vascular side while S6c had a more potent effect on airway conductance. ET‐1, given as a bolus dose intra‐arterially (100 μL of 0.2 nm ), induced a strong‐ and long‐lasting contraction of the vasculature while only a less pronounced contraction was seen in the airways. Neither of the antagonists had a significant effect per se on Gaw or perfusion flow. FR 139317 reduced the effect of ET‐1 on perfusion flow by about 50%, while airway conductance was augmented. BQ 788 enhanced the decrease in perfusion flow by ET‐1 while Gaw was not influenced. The combined ETA/ETB antagonist Bosentan powerfully prevented the ET‐1‐induced decrease in Gaw but did not alter its reduction in perfusion flow. Conclusions: The potent effect of ET‐1 on the vascular side of the lung is mediated mainly through ETA receptors, whereas both ETA and ETB receptors are involved in Gaw in the rat lung. 相似文献
9.
Thi Thu Ha Hoang Carina Bengtsson Dac Cam Phung Mikael Srberg Marta Granstrm 《Clinical and Vaccine Immunology : CVI》2005,12(1):81-85
Helicobacter pylori-associated diseases, such as peptic ulcer and gastric cancer, are common in Vietnam, but the prevalence of the infection is largely unknown. A validated enzyme-linked immunosorbent assay was used for seroepidemiology with 971 samples from the general population, ages 0 to 88 years, with 546 samples from an urban population (Hanoi), and with 425 samples from a poor, rural province (Hatay). The overall seroprevalence of the infection was 746 per 1,000, with a prevalence of 788 per 1,000 in Hanoi and 692 per 1,000 in Hatay (P = 0.0007). The risk for infection in the rural area of Hatay was 40% lower than in the urban population of Hanoi, with the odds ratio being 0.59 (95% confidence interval, 0.43 to 0.81). The study shows that the prevalence of H. pylori infection is high in Vietnam and especially high in a large urban area, such as the city of Hanoi. 相似文献
10.
OBJECTIVE: To examine children's competence while cycling, as demonstrated in mistakes in performance and failure to comply with safety rules. METHODS: Children in three age groups (8, 10, and 12 years) participated in a realistic yet simulated traffic environment. RESULTS: The boys' cycling speed increased steadily with age, while that of the girls increased from 8 to 10 but decreased at age 12. Most children had adequate motor control by age 10, and the youngest compensated for their less developed skills by cycling slowly and braking early at junctions. Serious mistakes, often related to the children's age and gender, consisted of the children failing to stop at signals or stopping too late, especially at short stopping range. CONCLUSIONS: There are considerable individual differences in children's cycling competence that are related to biological factors, such as age and gender, and psychological factors, such as rule compliance and choice of cycling speed. 相似文献