全文获取类型
收费全文 | 148篇 |
免费 | 14篇 |
专业分类
儿科学 | 15篇 |
基础医学 | 10篇 |
口腔科学 | 3篇 |
临床医学 | 19篇 |
内科学 | 41篇 |
皮肤病学 | 2篇 |
神经病学 | 12篇 |
特种医学 | 1篇 |
外科学 | 15篇 |
预防医学 | 4篇 |
眼科学 | 11篇 |
药学 | 5篇 |
肿瘤学 | 24篇 |
出版年
2021年 | 3篇 |
2020年 | 2篇 |
2019年 | 1篇 |
2018年 | 1篇 |
2016年 | 3篇 |
2015年 | 4篇 |
2014年 | 3篇 |
2013年 | 7篇 |
2012年 | 8篇 |
2011年 | 9篇 |
2010年 | 4篇 |
2009年 | 5篇 |
2008年 | 5篇 |
2007年 | 2篇 |
2006年 | 12篇 |
2005年 | 8篇 |
2004年 | 8篇 |
2003年 | 9篇 |
2002年 | 6篇 |
2001年 | 4篇 |
2000年 | 4篇 |
1999年 | 6篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1996年 | 2篇 |
1994年 | 1篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1989年 | 3篇 |
1988年 | 3篇 |
1987年 | 6篇 |
1986年 | 3篇 |
1984年 | 3篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1978年 | 1篇 |
1976年 | 1篇 |
1975年 | 3篇 |
1973年 | 1篇 |
1970年 | 4篇 |
1969年 | 1篇 |
1968年 | 2篇 |
1967年 | 2篇 |
1966年 | 1篇 |
排序方式: 共有162条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
Stefanie J.G. Veenhuis MD Nienke J.H. van Os MD PhD Anjo J.W.M. Janssen PhD Marjo H.J.C. van Gerven MSc Karlien L.M. Coene PhD Udo. F.H. Engelke PhD Ron A. Wevers PhD Gerjen H. Tinnevelt PhD Rob ter Heine PhD Bart P.C. van de Warrenburg MD PhD Corry M.R. Weemaes MD PhD Nel Roeleveld PhD Michèl A.A.P. Willemsen MD PhD 《Movement disorders》2021,36(12):2951-2957
5.
Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome. 总被引:3,自引:1,他引:3 下载免费PDF全文
Christian M Zwaan Gertjan J L Kaspers Rob Pieters Karel H?hlen Gritta E Janka-Schaub Christina H van Zantwijk Dieuwke R Huismans Esther de Vries Marianne G Rots Godefridus J Peters Gerrit Jansen Ursula Creutzig Anjo J P Veerman 《Blood》2002,99(1):245-251
Children with Down syndrome (DS) have an increased risk for leukemia. The prognosis for DS acute myeloid leukemia (AML) is better than for non-DS AML, but the clinical outcome of DS acute lymphoblastic leukemia (ALL) is equal to that of non-DS ALL. Differences in prognosis may reflect differences in cellular drug resistance. In vitro drug resistance profiles were successfully investigated on leukemic cells from 13 patients with DS AML and 9 patients with DS ALL and were compared with reference data from 151 non-DS AML and 430 non-DS B-cell precursor (BCP) ALL. DS AML cells were significantly more sensitive to cytarabine (median, 12-fold), the anthracyclines (2-7-fold), mitoxantrone (9-fold), amsacrine (16-fold), etoposide (20-fold), 6-thioguanine (3-fold), busulfan (5-fold), vincristine (23-fold), and prednisolone (more than 1.1-fold), than non-DS AML cells. Compared with DS ALL, DS AML cells were significantly more sensitive to cytarabine only (21-fold). After short-term exposure to methotrexate, DS AML cells were 21-fold more resistant than non-DS AML cells, but no difference was observed after continuous exposure. DS ALL cells and non-DS BCP-ALL cells were equally sensitive to all drugs, including methotrexate. Normal peripheral blood mononuclear cells from DS and non-DS children without leukemia showed highly resistant drug profiles. It was concluded that the better prognosis of DS AML might, at least partially, be explained by a specific, relatively sensitive drug-resistance profile, reflecting the unique biology of this disease. (Blood. 2002;99:245-251) 相似文献
6.
Guettier C Validire P Emilie D Tricottet V Sebagh M Anjo A Misset JL Reynes M 《Virchows Archiv : an international journal of pathology》2006,448(2):218-222
Follicular dendritic cell tumor (FDCT) is a rare tumor mainly located in laterocervical lymph nodes. We report one case of
mediastinal FDCT associated with a history of bullous skin disease and clinically obvious immunosuppression. This tumor was
characterized by heavy mast cell infiltration. Mast cells were in close relationship with tumor cells as demonstrated by ultrastructural
examination and their presence are probably related with the strong expression of mast cell chemoattractants as fraktalkine
and stromal cell-derived factor-1α by tumor cells. The long follow-up period of more than 17 years allowed to us assess the
relatively indolent evolution of this tumor characterized by three slowly growing local recurrences without metastasis. 相似文献
7.
Hidetoshi Saegusa
dds Satoshi Watanabe
dds Tomoo Anjo
dds phd Arata Ebihara
dds phd Hideaki Suda
dds phd 《Australian endodontic journal : the journal of the Australian Society of Endodontology Inc》2010,36(1):6-11
The aim of this study was to investigate the safety of laser use under the dental microscope. Nd:YAG, Er:YAG and diode lasers were used. The end of the tips was positioned at a distance of 5 cm from the objective lens of a dental microscope. Each eye protector was made into a flat disc, which was fixed on the lens of the microscope. The filters were placed in front of the objective lens or behind the eye lens. Transmitted energy through the microscope with or without the filters was measured. No transmitted laser energy was detected when using matched eye protectors. Mismatched eye protectors were not effective for shutting out laser energy, especially for Nd:YAG and diode lasers. None or very little laser energy was detected through the microscope even without any laser filter. Matched filters shut out all laser energy irrespective of their positions. 相似文献
8.
Nunes CM Pena FC Negrelli GB Anjo CG Nakano MM Stobbe NS 《Revista de saúde pública》2000,34(6):656-658
There are sandboxes in public elementary school playground areas in Brazil, which can be harmful to children. They are at risk of cutaneous and visceral larva migrans infection caused by Ancylostoma spp. and Toxocara spp., respectively. The study was designed to investigate contamination by Toxocara spp. and/or their eggs and Ancylostoma spp. larvae in sand samples collected from the schools' sandboxes. Five hundred and thirty-five sand samples from 28 public elementary schools were collected during summer and winter and analyzed by both Baerman's method and centrifugal flotation technique. Ancylostoma spp. larvae were found in 35.7% (10/28) schools in summer time and in 46.4% (13/28) schools in the winter time. Eggs of Toxocara spp. could not be recovered from the samples analyzed and eggs from Ancylostoma spp. were seen in 0.56% (3/535) of the samples. 相似文献
9.
Three cases of painful ophthalmoplegia have been described in which symptoms suggesting a tumor of the orbit justified neuroradiological assessment. Phlebography in each case revealed stenosis of the superior ophthalmic vein in its third portion, and non-opicification of the cavernous sinus. Hirtz incidences revealed contralateral cavernous sinus opacification and venous drainage through the coronary sinus. These neuradiological findings helped to differentiate this syndrome from other affections which have similar signs and symptoms. 相似文献
10.