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1.
Mehraj D. Tantray Asim Rather Qazi Manaan Irfan Andleeb Mir. Mohammad Yasmeena Gull 《Strategies in trauma and limb reconstruction (Online)》2018,13(2):81-85
Removal of foreign bodies from soft tissues in emergency is very challenging and becomes more problematic when it is radiolucent. Blind exploration is sometimes hazardous for patients especially when it is in proximity to a vessel or a nerve or an overlying tendon. The purpose of this study was to determine the accuracy of ultrasonography (USG) in detecting radiolucent soft tissue foreign bodies in the extremities. From January 2014 to January 2016, 120 patients with either a positive history or clinically suspected soft tissue foreign body and negative radiography were evaluated by USG with a high-frequency (13–6 MHz) linear-array transducer. The sonographic findings were used to guide surgical exploration. Out of 120 patients who underwent surgical exploration, USG was positive in 114 cases, and foreign body was retrieved in 108 cases, and among the six cases where USG was negative, foreign body was retrieved from one case. In one case with strong clinical suspicion of foreign body USG was falsely negative. Majority of foreign bodies were removed from foot (69 cases) and hands (26 cases), and rest of foreign bodies were removed from ankle (4 cases), wrist (3 cases), thigh (2 cases), leg (1 case), knee (2 cases), forearm (2 cases). Accuracy, sensitivity, and positive predictive value were determined as 94.16, 99.08, and 94.13%, respectively. The real-time high-frequency USG is a highly sensitive and accurate tool for detecting and removing radiolucent foreign bodies which cannot be visualized by routine radiography. 相似文献
2.
Mitchell W. Pesesky Tahir Hussain Meghan Wallace Bin Wang Saadia Andleeb Carey-Ann D. Burnham Gautam Dantas 《Emerging infectious diseases》2015,21(6):1034-1037
To characterize the genomic context of New Delhi metallo-β-lactamase-1 (NDM-1) and Klebsiella pneumoniae carbapenemase (KPC), we sequenced 78 Enterobacteriaceae isolates from Pakistan and the United States encoding KPC, NDM-1, or no carbapenemase. High similarities of the results indicate rapid spread of carbapenem resistance between strains, including globally disseminated pathogens. 相似文献
3.
Andleeb Abrari Mehar Aziz S. C. Sharma Vandana Baksi 《Indian journal of otolaryngology and head and neck surgery》2006,58(2):206-207
Cervical lymphnodal metastases from unsuspected primary melanoma is a particularly refractory clinical diagnostic situation. Judicious use of FNAC may render the correct diagnosis if discriminant criteria are strictly adhered to. Two cases with enlarged cervical lymphnodes, diagnosed as metastatic malignant melanoma on cytology, are reported. 相似文献
4.
Systemic lupus erythematosus (SLE) is an autoimmune disorder that can involve the central nervous system (CNS). Recently, we reported the presence of autoantibodies bound to the brain tissue of murine models of lupus; MRL/lpr and BXSB. We postulated that the source of these autoantibodies was in part due to in situ production, caused by the entry of B and T cells. Frozen brain sections of MRL/lpr and BXSB at 1 and 4 months of age were stained for CD3 (T cells) and CD19 (B cells) markers using an immunofluorescent antibody binding assay. Confocal fluorescence microscopy showed both CD3(+) and CD19(+) cells at 4 months of age only in MRL/lpr mice. There were no lymphocytes seen in the other autoimmune model, BXSB. Results suggest a difference in the mechanisms by which autoantibodies access the brain in these two autoimmune models of lupus. 相似文献
5.
Abid Qureshi Vaqar Gani Tantray Altaf Rehman Kirmani Abdul Ghani Ahangar 《Reviews in medical virology》2018,28(4)
Viral diseases like influenza, AIDS, hepatitis, and Ebola cause severe epidemics worldwide. Along with their resistant strains, new pathogenic viruses continue to be discovered so creating an ongoing need for new antiviral treatments. RNA interference is a cellular gene‐silencing phenomenon in which sequence‐specific degradation of target mRNA is achieved by means of complementary short interfering RNA (siRNA) molecules. Short interfering RNA technology affords a potential tractable strategy to combat viral pathogenesis because siRNAs are specific, easy to design, and can be directed against multiple strains of a virus by targeting their conserved gene regions. In this review, we briefly summarize the current status of siRNA therapy for representative examples from different virus families. In addition, other aspects like their design, delivery, medical significance, bioinformatics resources, and limitations are also discussed. 相似文献
6.
Since the advent of four-port laparoscopic cholecystectomy, many modifications regarding port number and size have been tried.
The feasibility of three-port technique has been found comparable to the conventional four-port laparoscopic cholecystectomy.
To assess the feasibility and safety of three-port laparoscopic cholecystectomy in a prospective study. Between March 2007
and March 2009, fifty patients with cholelithiasis aged between 15 and 56 years underwent three-port cholecystectomy in a
prospective study in Government medical college, Srinagar. A single surgeon did all the cases and there was no criterion for
the patient selection. These were consecutive fifty surgeries done by the surgeon. The outcome was assessed in terms of intra-operative
and post-operative parameters. The mean (range) age was 45 (15–56) years and there were thirty-nine females and eleven males
in the study. All the procedures were completed successfully without any conversions to open or any major complications; though
three patients needed the addition of a fourth port as in conventional laparoscopic cholecystectomy. The mean (range) operative
time was 55 (30–90) min and the average blood loss was 30 ml. The mean (range) hospital stay was 1 (1–3) days. All patients
returned to routine work within 1 week of surgery. The mean follow-up was 5 (2–7) months. We conclude, from the results above,
that three-port laparoscopic cholecystectomy is safe and feasible. There are only two visible surgical scars, better cosmetic
appearance with no increased risk of bile duct injury. It reduces the manpower in the form of a second assistant. Thus, it
can be recommended as a safe alternative procedure to conventional four-port laparoscopic cholecystectomy. 相似文献
7.
8.
Andleeb Abrari Mehar Aziz S. C. Sharma Vandana Baksi 《Indian journal of otolaryngology and head and neck surgery》2006,58(2):206-207
Cervical lymphnodal metastases from unsuspected primary melanoma is a particularly refractory clinical diagnostic situation.
Judicious use of FNAC may render the correct diagnosis if discriminant criteria are strictly adhered to. Two cases with enlarged
cervical lymphnodes, diagnosed as metastatic malignant melanoma on cytology, are reported. 相似文献
9.
Sobia Durrani Zahoor Khan Rehman Mehmood Khattak Mehwish Andleeb Muhammad Ali Hafsa Hameed Asia Taqddas Mamona Faryal Shumaila Kiran Humera Anwar Muhammad Riaz Muhammad Sajid Rehan Sadiq Sheikh Muhammad Ali Furhan Iqbal 《亚太热带病杂志(英文版)》2012,2(1):43-47
ObjectiveTo compare the presence of Theileria ovis in small ruminants from two provinces of Pakistan and to determine the risk factors associated with the spread of theileriosis.MethodsIn present study, a total of 210 blood samples were collected from sheep (n=99) and goats (n=111) from 5 sampling sites in Punjab (Dera Ghazi Khan, Layyah, Multan and Rahim Yar Khan districts) and Khyber Pukhtoon Khwa (district Kohat) provinces, in Pakistan, from randomly selected herds. Data on the characteristics of the animals (species, gender, age, tick presence or absence, prior treatment for babesiosis) and the herd (location, size, species of animals, dogs associated with the herds, tick burden of dogs associated with the herds) was collected through questionnaires.ResultsTwelve blood samples (6% of total), 11 from district Kohat, produced the 520 base pairs DNA fragment specific for small subunit ribosomal RNA (ssu rRNA) gene of Theileria ovis, by PCR amplification, of which 11 were sheep and 1 was goat indicating that sheep are more significantly (P=0.001) prone to this parasite. On the other hand parasite was detected only in 2 out of 210 samples (1%) by blood smear screening confirming PCR as the reliable detection tool.ConclusionsPCR is more sensitive and reliable diagnostic tool for detection of Theileria sp. as compared to blood smear screening. Incidence of Theileria ovis is very high in Khyber Pukhtoon Khwa as compared to Punjab province. It was also observed that presence of ticks on animals was the only significant risk factor associated with the theileriosis in small ruminants. 相似文献
10.
Finding genetic contributions to sporadic disease: a recessive locus at 12q24 commonly contributes to patent ductus arteriosus
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Mani A Meraji SM Houshyar R Radhakrishnan J Mani A Ahangar M Rezaie TM Taghavinejad MA Broumand B Zhao H Nelson-Williams C Lifton RP 《Proceedings of the National Academy of Sciences of the United States of America》2002,99(23):15054-15059
The causes of many sporadic diseases are unexplained; the contribution of recessive loci with reduced penetrance is one possibility that has been difficult to explore. We describe an approach to this problem by first searching for diseases with higher prevalence in populations with high rates of consanguinity, then determining whether disease cases are more commonly the product of consanguinous union than controls in such populations, followed by analysis of genetic linkage in consanguinous cases. We demonstrate the utility of this approach by investigation of congenital heart disease in Iran. We found that patent ductus arteriosus (PDA), a common congenital heart disease, accounts for a higher fraction of congenital heart disease in Iran (15%) than in the United States (2-7%). Moreover, Iranian PDA cases demonstrated a marked increase of parental consanguinity (63%), compared with the general Iranian population (25%) or control cases with tetralogy of Fallot (30%). The recurrence of PDA among siblings was 5%. A genomewide analysis of linkage in 21 unrelated consanguinous PDA cases demonstrated a multipoint logarithm of odds score of 6.27 in favor of linkage of PDA to a 3-centimorgan interval of chromosome 12q24, with 53% of kindreds linked. These findings together establish a recessive component to PDA and implicate a single locus, PDA1, in one third or more of all PDA cases in Iran; they further suggest a role for this locus in PDA worldwide. Finally, these results suggest a general approach to the identification of recessive contributions to sporadic diseases. 相似文献