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排序方式: 共有50条查询结果,搜索用时 15 毫秒
1.
Patel Shyam Kakouri Agni Chaudhary Shweta Knepper Paul A. Pfahler Nicholas M. Samples John Giovingo Michael 《Lasers in medical science》2021,36(3):605-609
Lasers in Medical Science - To evaluate the effect of various media and Iridex MicroPulse P3 (MP3) probe angles on the power output from the Cyclo G6 Glaucoma Laser (G6) System. A laser power meter... 相似文献
2.
Mara Simopoulou Konstantinos Sfakianoudis Evangelos Maziotis Nikolaos Antoniou Anna Rapani George Anifandis Panagiotis Bakas Stamatis Bolaris Agni Pantou Konstantinos Pantos Michael Koutsilieris 《Journal of assisted reproduction and genetics》2018,35(9):1545-1557
Mathematics rules the world of science. Innovative technologies based on mathematics have paved the way for implementation of novel strategies in assisted reproduction. Ascertaining efficient embryo selection in order to secure optimal pregnancy rates remains the focus of the in vitro fertilization scientific community and the strongest driver behind innovative approaches. This scoping review aims to describe and analyze complex models based on mathematics for embryo selection, devices, and software most widely employed in the IVF laboratory and algorithms in the service of the cutting-edge technology of artificial intelligence. Despite their promising nature, the practicing embryologist is the one ultimately responsible for the success of the IVF laboratory and thus the one to approve embracing pioneering technologies in routine practice. Applied mathematics and computational biology have already provided significant insight into the selection of the most competent preimplantation embryo. This review describes the leap of evolution from basic mathematics to bioinformatics and investigates the possibility that computational applications may be the means to foretell a promising future for the IVF clinical practice. 相似文献
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Whelan JS McTiernan A Kakouri E Kilby A;London Bone Soft Tissue Tumour Service 《Pediatric blood & cancer》2004,43(3):237-242
BACKGROUND: Failure of first line therapy for the Ewing's family of tumours (EFT) is associated with a very poor outlook. Studies of second line chemotherapy are therefore necessary to identify active agents and drug combinations. Cisplatin-based therapy is frequently used in these circumstances but there are few studies to clearly define activity and toxicity. This report details outcome in a cohort of patients with poor risk EFT treated with a carboplatin-based combination. PROCEDURE: Between 1990 and 1998, 23 males and 16 females aged between 6 and 48 years (median 23) with relapsed or refractory EFT were treated with carboplatin-based chemotherapy. Previous chemotherapy had included ifosfamide and doxorubicin in all but two patients. Twenty patients were treated at the time of recurrence, and 19 after a poor response to initial chemotherapy. Treatment comprised of carboplatin to give an area under the plasma carboplatin concentration versus time curve of (AUC) 6 mg/ml, etoposide 120 mg/m2 for 3 days, and cyclophosphamide 500-750 mg/m2 for 2 days, repeated every 21 days. RESULTS: A total of 105 cycles were given, median 2 per patient (range 1-5). Overall response was 26%, with one complete response and nine partial responses. Median time to progression was 10 weeks (range 2-54). Haematological toxicity was severe requiring dose reductions in 53% of patients. Six patients proceeded to high dose consolidation treatment with bone marrow or peripheral stem cell rescue. CONCLUSIONS: This combination results in a substantial response rate in previously treated patients but with significant toxicity. Responses are, however, relatively short. 相似文献
5.
Chylotamponade: an unusual presentation of Gorham's syndrome 总被引:2,自引:0,他引:2
Swelstad MR Frumiento C Garry-McCoy A Agni R Weigel TL 《The Annals of thoracic surgery》2003,75(5):1650-1652
Gorham's Syndrome, also known as massive osteolysis or "vanishing bone disease" results from lymphangiomatosis with adjacent bone resorption. Chylothorax is a common complication in cases of mediastinal involvement. We report a case of Gorham's Syndrome presenting as chylotamponade successfully treated with pericardial drainage, early parenteral nutritional support, bilateral pleurodesis for chylous effusions, and adjuvant external beam radiation. 相似文献
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Comparison of success rate and intraocular pressure spikes between selective laser trabeculoplasty and micropulse laser trabeculoplasty in African American and Hispanic patients
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Alexander Z Robin Palwasha Syar Dana Darwish Catherine Thomas N.M. Pfahler Agni Kakouri Thomas Patrianakos Michael Giovingo 《国际眼科》2023,16(1):75-80
AIM: To examine the efficacy and safety of micropulse laser trabeculoplasty (MLT) versus selective laser trabeculoplasty (SLT) in a large cohort of primarily African American and Hispanic patients.
METHODS: A single center retrospective comparative cohort review conducted at Cook County Health facilities that included patients with a diagnosis of open angle glaucoma or ocular hypertension who received an SLT or MLT procedure between January 2017 and May 2021.
RESULTS: Totally 131 eyes of 99 patients were analyzed. The 77 eyes received SLT and 54 received MLT. Seven out of 77 eyes in the SLT group (9.1%) and 1 out of 54 eyes in the MLT group (1.9%) had an IOP spike (defined as > 5 mm Hg) at either 1h or 1wk after procedure (P=0.05, Chi-squared test with Haldane-Anscombe correction). The procedure failure rate at one year was 50% for SLT and 48% for MLT (P=0.31).
CONCLUSION: MLT has a significantly lower incidence of pressure spikes and a similar treatment failure rate at 1-year post-procedure, demonstrating that it is a reasonable alternative compared to SLT. 相似文献
8.
M.A. Loizidou A. Hadjisavvas P. Pirpa E. Spanou T. Delikurt G.A. Tanteles M. Daniel P. Kountourakis S. Malas G. Ioannidis I. Zouvani E. Kakouri D. Papamichael Y. Marcou V. Anastasiadou K. Kyriacou 《Clinical genetics》2017,91(4):611-615
This paper presents the largest study in Cyprus evaluating the frequency and distribution of BRCA1/2 mutations in a high risk patient cohort. Deleterious mutations in the BRCA1/2 genes were identified in 68 of the 527 patients tested (13%). It is of interest that a quarter of those tested positive, did not have an extensive family history of breast/ovarian cancer but were diagnosed with early onset breast cancer, ovarian cancer under the age of 60 or triple negative breast cancer. The spectrum of mutations identified in our patient cohort is different compared to other Mediterranean countries. Furthermore, several of the mutations detected are novel and have not been identified in other ethnic populations. This highlights the importance of operating a national reference center for cancer genetic diagnosis which offers services tailored to the needs of the Cypriot population. 相似文献
9.
NS Artz CD Hines ST Brunner RM Agni JP Kühn A Roldan-Alzate GH Chen SB Reeder 《Investigative radiology》2012,47(10):603-610
10.
Hines CD Agni R Roen C Rowland I Hernando D Bultman E Horng D Yu H Shimakawa A Brittain JH Reeder SB 《Journal of magnetic resonance imaging : JMRI》2012,35(4):844-851